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Tbio
CCT4
T-complex protein 1 subunit delta

Protein Summary
Description
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394440
  • ENSP00000377958
  • ENSG00000115484
  • ENST00000544079
  • ENSP00000443061

Symbol
  • CCTD
  • SRB
  • SRB
  • Cctd
  • CCT-DELTA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
kinase perturbation
1
virus perturbation
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.44   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 220   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.44   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
1
1
2
20.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
2
20.4
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
chaperonin containing TCP1 subunit 4
VGNC:185
745811
Macaque
chaperonin containing TCP1 subunit 4
719649
Mouse
MGI:104689
12464
Rat
RGD:727937
29374
Dog
chaperonin containing TCP1 subunit 4
VGNC:38924
100855692
Species
Name
OMA
EggNOG
Inparanoid
Chimp
chaperonin containing TCP1 subunit 4
Macaque
chaperonin containing TCP1 subunit 4
Mouse
Rat
Dog
chaperonin containing TCP1 subunit 4
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P50991-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Chaperonin-mediated protein folding
Reactome
Cilium Assembly
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Chaperonin-mediated protein folding
Cilium Assembly
Gene Ontology Terms (23)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (491)
1 – 10 of 491
FBXW4
Tbio
Novelty: 0.06255177
p_int: 0.996740908
p_ni: 0.003259092
Score: 0.95
Data Source: BioPlex,STRINGDB
MYH7B
Tbio
Novelty: 0.00864941
p_int: 0.994126077
p_ni: 0.005873924
Data Source: BioPlex
KLHL33
Tdark
Novelty: 1.42677156
p_int: 0.993761172
p_ni: 0.006238828
Score: 0.288
Data Source: BioPlex,STRINGDB
CCT3
Tbio
Novelty: 0.01642521
p_int: 0.99348944
p_ni: 0.00651056
Score: 0.999
Data Source: BioPlex,STRINGDB
KLHDC8A
Tdark
Novelty: 1.43751731
p_int: 0.992208102
p_ni: 0.007791898
Score: 0.313
Data Source: BioPlex,STRINGDB
POC1A
Tbio
Novelty: 0.03897985
p_int: 0.990788215
p_ni: 0.009211785
Score: 0.255
Data Source: BioPlex,STRINGDB
PEX7
Tbio
Novelty: 0.01487923
p_int: 0.990321779
p_ni: 0.009678221
Score: 0.577
Data Source: BioPlex,STRINGDB
KDM4B
Tchem
Family: Epigenetic
Novelty: 0.01615072
p_int: 0.986038659
p_ni: 0.013961341
Score: 0.288
Data Source: BioPlex,STRINGDB
ACTR3B
Tbio
Novelty: 0.06033214
p_int: 0.985766052
p_ni: 0.014233948
Score: 0.404
Data Source: BioPlex,STRINGDB
RAP2C
Tbio
Family: Enzyme
Novelty: 0.08572837
p_int: 0.984055745
p_ni: 0.015944255
Score: 0.306
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  77.44

PubMed score by year
PubTator Score  437.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer