Tbio CCT4 T-complex protein 1 subunit delta

Protein Classes

PANTHER Classes

Protein / Chaperone / Chaperonin / T-complex Protein 1 Subunit Delta

DTO Classes

Protein / Chaperone / Chaperonin / T-complex Protein 1 Subunit Delta

Protein Summary

Description

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• P50991
• B2R6I3
• B7Z8B1
• F5H5W3
• O14870
• Q53QP9
• Q96C51
• TCP-1-delta

Gene Name

• CCT4

Ensembl ID

• ENST00000394440
• ENSP00000377958
• ENSG00000115484
• ENST00000544079
• ENSP00000443061

Symbol

• CCTD
• SRB
• SRB
• Cctd
• CCT-DELTA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
hub protein	1
interacting protein	1
kinase perturbation	1
virus perturbation	0.94

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Target Illumination GWAS Analytics (TIGA)

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.44   (req: < 5)

Gene RIFs: 3   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.44   (req: >= 5)

Gene RIFs: 3   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
amino acid measurement	EFO_0005134	1	1	2		20.4

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
amino acid measurement	EFO_0005134	2		20.4

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Orthologs (16)

1 – 5 of 16

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	chaperonin containing TCP1 subunit 4	VGNC:185	745811
Macaque	chaperonin containing TCP1 subunit 4		719649
Mouse	chaperonin containing Tcp1, subunit 4 (delta)	MGI:104689	12464
Rat	chaperonin containing TCP1 subunit 4	RGD:727937	29374
Dog	chaperonin containing TCP1 subunit 4	VGNC:38924	100855692

Species	Name	OMA	EggNOG	Inparanoid
Chimp	chaperonin containing TCP1 subunit 4
Macaque	chaperonin containing TCP1 subunit 4
Mouse	chaperonin containing Tcp1, subunit 4 (delta)
Rat	chaperonin containing TCP1 subunit 4
Dog	chaperonin containing TCP1 subunit 4

Protein Structure (0 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-P50991-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (13)

Reactome (13)

Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Association of TriC/CCT with target proteins during biosynthesis	39 targets	R-HSA-390471
Reactome	BBSome-mediated cargo-targeting to cilium	23 targets	R-HSA-5620922
Reactome	Cargo trafficking to the periciliary membrane	51 targets	R-HSA-5620920
Reactome	Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Reactome	Cilium Assembly	187 targets	R-HSA-5617833

Name	Explore in Pharos	Explore in Source
Association of TriC/CCT with target proteins during biosynthesis	39 targets	R-HSA-390471
BBSome-mediated cargo-targeting to cilium	23 targets	R-HSA-5620922
Cargo trafficking to the periciliary membrane	51 targets	R-HSA-5620920
Chaperonin-mediated protein folding	96 targets	R-HSA-390466
Cilium Assembly	187 targets	R-HSA-5617833

Gene Ontology Terms (23)

Functions (3)

Components (10)

Processes (10)

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1 – 3 of 3

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
unfolded protein binding	Traceable Author Statement (TAS)	ProtInc
ATP binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (491)

Explore Interacting Targets

1 – 10 of 491

• See Interactions on String-DB

FBXW4

Tbio

Novelty: 0.06255177

p_int: 0.996740908

p_ni: 0.003259092

Score: 0.95

Data Source: BioPlex,STRINGDB

MYH7B

Tbio

Novelty: 0.00864941

p_int: 0.994126077

p_ni: 0.005873924

Data Source: BioPlex

KLHL33

Tdark

Novelty: 1.42677156

p_int: 0.993761172

p_ni: 0.006238828

Score: 0.288

Data Source: BioPlex,STRINGDB

CCT3

Tbio

Novelty: 0.01642521

p_int: 0.99348944

p_ni: 0.00651056

Score: 0.999

Data Source: BioPlex,STRINGDB

KLHDC8A

Tdark

Novelty: 1.43751731

p_int: 0.992208102

p_ni: 0.007791898

Score: 0.313

Data Source: BioPlex,STRINGDB

POC1A

Tbio

Novelty: 0.03897985

p_int: 0.990788215

p_ni: 0.009211785

Score: 0.255

Data Source: BioPlex,STRINGDB

PEX7

Tbio

Novelty: 0.01487923

p_int: 0.990321779

p_ni: 0.009678221

Score: 0.577

Data Source: BioPlex,STRINGDB

KDM4B

Tchem

Family: Epigenetic

Novelty: 0.01615072

p_int: 0.986038659

p_ni: 0.013961341

Score: 0.288

Data Source: BioPlex,STRINGDB

ACTR3B

Tbio

Novelty: 0.06033214

p_int: 0.985766052

p_ni: 0.014233948

Score: 0.404

Data Source: BioPlex,STRINGDB

RAP2C

Tbio

Family: Enzyme

Novelty: 0.08572837

p_int: 0.984055745

p_ni: 0.015944255

Score: 0.306

Data Source: BioPlex,STRINGDB

Publication Statistics

PubMed Score  77.44

PubMed score by year

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PubTator Score  437.98

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

Acetylation
Alternative splicing
ATP-binding
Cell projection
Chaperone
Complete proteome
Cytoplasm
Cytoskeleton
Direct protein sequencing
Methylation

GWAS Trait Find Similar Targets

amino acid measurement