Tbio CCT4 T-complex protein 1 subunit delta

Protein Summary

Description

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as alpha-transducin (MIM 139330) (Won et al., 1998 [PubMed 9819444]).[supplied by OMIM, Mar 2008]

Uniprot Accession IDs

• P50991
• B2R6I3
• B7Z8B1
• F5H5W3
• O14870
• Q53QP9
• Q96C51
• TCP-1-delta

Gene Name

• CCT4

Ensembl ID

• ENST00000394440
• ENSP00000377958
• ENSG00000115484
• ENST00000544079
• ENSP00000443061

Symbol

• CCTD
• SRB
• SRB
• Cctd
• CCT-DELTA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
hub protein	1
interacting protein	1
kinase perturbation	1
virus perturbation	0.94

Protein Classes

PANTHER Classes

Protein / Chaperone / Chaperonin / T-complex Protein 1 Subunit Delta

DTO Classes

Protein / Chaperone / Chaperonin / T-complex Protein 1 Subunit Delta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.99   (req: < 5)

Gene RIFs: 4   (req: <= 3)

Antibodies: 220   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 105.99   (req: >= 5)

Gene RIFs: 4   (req: > 3)

Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0