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Tbio
CCT4
T-complex protein 1 subunit delta

Protein Classes
PANTHER Classes Protein / Chaperone / Chaperonin / T-complex Protein 1 Subunit Delta
Protein Summary
Description
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). The chaperonin containing TCP1 (MIM 186980) complex (CCT), also called the TCP1 ring complex, consists of 2 back-to-back rings, each containing 8 unique but homologous subunits, such as CCT4. CCT assists the folding of newly translated polypeptide substrates through multiple rounds of ATP-driven release and rebinding of partially folded intermediate forms. Substrates of CCT include the cytoskeletal proteins actin (see MIM 102560) and tubulin (see MIM 191130), as well as a ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000394440
  • ENSP00000377958
  • ENSG00000115484
  • ENST00000544079
  • ENSP00000443061

Symbol
  • CCTD
  • SRB
  • SRB
  • Cctd
  • CCT-DELTA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
hub protein
1
interacting protein
1
kinase perturbation
1
virus perturbation
0.94


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.89   (req: < 5)
View Publications
Gene RIFs: 3   (req: <= 3)
View Gene RIFs
Antibodies: 220   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 60.89   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 220   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (13)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
39 targets
R-HSA-390471
Reactome
BBSome-mediated cargo-targeting to cilium
23 targets
R-HSA-5620922
Reactome
Cargo trafficking to the periciliary membrane
51 targets
R-HSA-5620920
Reactome
Chaperonin-mediated protein folding
96 targets
R-HSA-390466
Reactome
Cilium Assembly
187 targets
R-HSA-5617833
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
39 targets
R-HSA-390471
BBSome-mediated cargo-targeting to cilium
23 targets
R-HSA-5620922
Cargo trafficking to the periciliary membrane
51 targets
R-HSA-5620920
Chaperonin-mediated protein folding
96 targets
R-HSA-390466
Cilium Assembly
187 targets
R-HSA-5617833
Gene Ontology Terms (23)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
RNA binding
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
unfolded protein binding
Traceable Author Statement (TAS)
ProtInc
ATP binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (491)
1 – 10 of 491
FBXW4
Tbio
Novelty: 0.0652799
p_int: 0.996740908
p_ni: 0.003259092
Score: 0.95
Data Source: BioPlex,STRINGDB
MYH7B
Tbio
Novelty: 0.01329839
p_int: 0.994126077
p_ni: 0.005873924
Data Source: BioPlex
KLHL33
Tdark
Novelty: 12
p_int: 0.993761172
p_ni: 0.006238828
Score: 0.288
Data Source: BioPlex,STRINGDB
CCT3
Tbio
Novelty: 0.00555442
p_int: 0.99348944
p_ni: 0.00651056
Score: 0.999
Data Source: BioPlex,STRINGDB
KLHDC8A
Tdark
p_int: 0.992208102
p_ni: 0.007791898
Score: 0.313
Data Source: BioPlex,STRINGDB
POC1A
Tbio
Novelty: 0.04826931
p_int: 0.990788215
p_ni: 0.009211785
Score: 0.255
Data Source: BioPlex,STRINGDB
PEX7
Tbio
Novelty: 0.02053523
p_int: 0.990321779
p_ni: 0.009678221
Score: 0.577
Data Source: BioPlex,STRINGDB
KDM4B
Tchem
Family: Epigenetic
Novelty: 0.01988196
p_int: 0.986038659
p_ni: 0.013961341
Score: 0.288
Data Source: BioPlex,STRINGDB
ACTR3B
Tbio
Novelty: 0.09881697
p_int: 0.985766052
p_ni: 0.014233948
Score: 0.404
Data Source: BioPlex,STRINGDB
RAP2C
Tbio
Family: Enzyme
Novelty: 0.19402525
p_int: 0.984055745
p_ni: 0.015944255
Score: 0.306
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  60.89

PubMed score by year
PubTator Score  437.98

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer