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Tbio
CCT8
T-complex protein 1 subunit theta

Protein Summary
Description
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286788
  • ENSP00000286788
  • ENSG00000156261
  • ENST00000540844
  • ENSP00000442730
  • ENST00000626972
  • ENSP00000486921

Symbol
  • C21orf112
  • CCTQ
  • KIAA0002
  • Cctq
  • PRED71
  • D21S246
  • C21orf112
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
hub protein
0.98
molecular function
0.94
protein domain
0.92
kinase perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.13   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 270   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 35.13   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (465)
1 – 10 of 465
CCT3
Tbio
Novelty:  0.01642521
p_int:  0.958967214
p_ni:  0.041032786
Score:  0.999
Data Source:  BioPlex,STRINGDB
POC1A
Tbio
Novelty:  0.03897985
p_int:  0.945915573
p_ni:  0.054084427
Score:  0.301
Data Source:  BioPlex,STRINGDB
BUB3
Tbio
Novelty:  0.00714143
p_int:  0.899299491
p_ni:  0.100700509
Score:  0.624
Data Source:  BioPlex,STRINGDB
KLHL33
Tdark
Novelty:  1.42677156
p_int:  0.862466785
p_ni:  0.137533215
Score:  0.638
Data Source:  BioPlex,STRINGDB
PEX7
Tbio
Novelty:  0.01487923
p_int:  0.856651192
p_ni:  0.143348807
p_wrong:  1e-9
Score:  0.842
Data Source:  BioPlex,STRINGDB
KLHDC8A
Tdark
Novelty:  1.43751731
p_int:  0.854033179
p_ni:  0.145966821
Score:  0.747
Data Source:  BioPlex,STRINGDB
FBXW4
Tbio
Novelty:  0.06255177
p_int:  0.817777305
p_ni:  0.182222695
Score:  0.95
Data Source:  BioPlex,STRINGDB
CERCAM
Tdark
Family:  Enzyme
Novelty:  0.33392502
p_int:  0.796534979
p_ni:  0.203465021
Data Source:  BioPlex
ACTR3B
Tbio
Novelty:  0.06033214
p_int:  0.792313944
p_ni:  0.207686055
Score:  0.641
Data Source:  BioPlex,STRINGDB
KDM4B
Tchem
Family:  Epigenetic
Novelty:  0.01615072
p_int:  0.777384101
p_ni:  0.222615899
Score:  0.638
Data Source:  BioPlex,STRINGDB
Pathways (17)
Association of TriC/CCT with target proteins during biosynthesis (R-HSA-390471)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Association of TriC/CCT with target proteins during biosynthesis
Reactome
BBSome-mediated cargo-targeting to cilium
Reactome
Cargo trafficking to the periciliary membrane
Reactome
Chaperonin-mediated protein folding
Reactome
Cilium Assembly
Name
Explore in Pharos
Explore in Source
Association of TriC/CCT with target proteins during biosynthesis
BBSome-mediated cargo-targeting to cilium
Cargo trafficking to the periciliary membrane
Chaperonin-mediated protein folding
Cilium Assembly
Gene Ontology Terms (29)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
2
23
92.7
reticulocyte measurement
3
1
3
80.9
reticulocyte count
2
1
2
80.2
serum gamma-glutamyl transferase measurement
2
2
2
75.4
4
3
4
61.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
23
92.7
reticulocyte measurement
3
80.9
reticulocyte count
2
80.2
serum gamma-glutamyl transferase measurement
2
75.4
4
61.3
Find similar targets by:
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
chaperonin containing TCP1 subunit 8
706184
Mouse
MGI:107183
12469
Rat
RGD:1305452
288305
Dog
chaperonin containing TCP1 subunit 8
VGNC:38927
478399
Horse
chaperonin containing TCP1 subunit 8
VGNC:16242
100053750
Species
Name
OMA
EggNOG
Inparanoid
Macaque
chaperonin containing TCP1 subunit 8
Mouse
Rat
Dog
chaperonin containing TCP1 subunit 8
Horse
chaperonin containing TCP1 subunit 8
Publication Statistics
PubMed Score 35.13
PubMed score by year
PubTator Score 21.87
PubTator score by year