Tbio CCT8 T-complex protein 1 subunit theta

Protein Summary

Description

Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]

Uniprot Accession IDs

• P50990
• A6NN54
• B4DEM7
• B4DQH4
• Q4VBP8
• TCP-1-theta

Gene Name

• CCT8

Ensembl ID

• ENST00000286788
• ENSP00000286788
• ENSG00000156261
• ENST00000540844
• ENSP00000442730
• ENST00000626972
• ENSP00000486921

Symbol

• C21orf112
• CCTQ
• KIAA0002
• Cctq
• PRED71
• D21S246
• C21orf112

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	1
hub protein	0.98
molecular function	0.94
protein domain	0.92
kinase perturbation	0.88

Protein Classes

PANTHER Classes

Protein / Chaperone / Chaperonin / T-complex Protein 1 Subunit Theta

DTO Classes

Protein / Chaperone / Chaperonin / T-complex Protein 1 Subunit Theta

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.37   (req: < 5)

Gene RIFs: 5   (req: <= 3)

Antibodies: 270   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 39.37   (req: >= 5)

Gene RIFs: 5   (req: > 3)

Antibodies: 270   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0