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Tbio
RPL14
60S ribosomal protein L14

Protein Summary
Description
Component of the large ribosomal subunit. Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L14E family of ribosomal proteins. It contains a basic region-leucine zipper (bZIP)-like domain. The protein is located in the cytoplasm. This gene contains a trinucleotide (GCT) repeat tract whose length is highly polymorphic; these triplet repeats result in a stretch of alanine residues in the encoded protein. Transcript variants utilizing alternative polyA signals and alternative 5'-terminal exons exist but all encode the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000338970
  • ENSP00000345156
  • ENSG00000188846
  • ENST00000396203
  • ENSP00000379506

Symbol
  • L14
  • RL14
  • hRL14
  • CTG-B33
  • CAG-ISL-7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
kinase perturbation
1
virus perturbation
0.99
co-expressed gene
0.87
disease perturbation
0.83


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.07   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 229   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 61.07   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 229   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
1
1
33.1
1
1
0
1.1
17.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil percentage of leukocytes
1
33.1
0
1.1
17.8
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L14
VGNC:2542
735578
Mouse
MGI:1914365
67115
Rat
RGD:621180
65043
Dog
ribosomal protein L14
477031
Horse
ribosomal protein L14
VGNC:22523
100067962
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ribosomal protein L14
Mouse
Rat
Dog
ribosomal protein L14
Horse
ribosomal protein L14
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P50914-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 32
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Cap-dependent Translation Initiation
Reactome
Developmental Biology
Reactome
Disease
Reactome
Eukaryotic Translation Elongation
Name
Explore in Pharos
Explore in Source
Axon guidance
Cap-dependent Translation Initiation
Developmental Biology
Disease
Eukaryotic Translation Elongation
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (466)
1 – 10 of 466
TRAF4
Tbio
Novelty:  0.01317133
p_int:  0.999994022
p_ni:  0.000005966
p_wrong:  1.2e-8
Data Source:  BioPlex
PUM3
Tbio
Novelty:  0.02344206
p_int:  0.999217667
p_ni:  0.000782333
Score:  0.366
Data Source:  BioPlex,STRINGDB
RPL36AL
Tbio
Novelty:  0.09336423
p_int:  0.998489864
p_ni:  0.001510135
Score:  0.997
Data Source:  BioPlex,STRINGDB
BUD13
Tbio
Novelty:  0.05228416
p_int:  0.998487543
p_ni:  0.001512457
Score:  0.555
Data Source:  BioPlex,STRINGDB
ZCCHC7
Tbio
Novelty:  0.01655453
p_int:  0.998298554
p_ni:  0.001701446
Score:  0.171
Data Source:  BioPlex,STRINGDB
ARGLU1
Tdark
Novelty:  0.28840832
p_int:  0.995202413
p_ni:  0.000213267
p_wrong:  0.00458432
Score:  0.515
Data Source:  BioPlex,STRINGDB
ZBTB24
Tbio
Family:  TF
Novelty:  0.041401
p_int:  0.993872479
p_ni:  0.00612751
p_wrong:  1.1e-8
Score:  0.286
Data Source:  BioPlex,STRINGDB
ZFP62
Tdark
Family:  TF
Novelty:  0.17608098
p_int:  0.990372498
p_ni:  0.009627502
Score:  0.378
Data Source:  BioPlex,STRINGDB
TAF1D
Tdark
Family:  Enzyme
Novelty:  0.26072519
p_int:  0.989951634
p_ni:  0.009982918
p_wrong:  0.000065447
Score:  0.517
Data Source:  BioPlex,STRINGDB
RPL26L1
Tdark
Novelty:  0.75408617
p_int:  0.981334432
p_ni:  0.018665568
Score:  0.999
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  61.07

PubMed score by year
PubTator Score  20.81

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer