You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
PPT1
Palmitoyl-protein thioesterase 1

Protein Summary
Description
Removes thioester-linked fatty acyl groups such as palmitate from modified cysteine residues in proteins or peptides during lysosomal degradation. Prefers acyl chain lengths of 14 to 18 carbons (PubMed:8816748). The protein encoded by this gene is a small glycoprotein involved in the catabolism of lipid-modified proteins during lysosomal degradation. The encoded enzyme removes thioester-linked fatty acyl groups such as palmitate from cysteine residues. Defects in this gene are a cause of infantile neuronal ceroid lipofuscinosis 1 (CLN1, or INCL) and neuronal ceroid lipofuscinosis 4 (CLN4). Two transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Dec 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000449045
  • ENSP00000392293
  • ENSG00000131238
  • ENST00000529905
  • ENSP00000432053
  • ENST00000642050
  • ENSP00000493153

Symbol
  • CLN1
  • PPT
  • PPT
  • CLN1
  • INCL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
disease perturbation
0.96
virus perturbation
0.96
biological process
0.93
kinase perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 414.15   (req: < 5)
Gene RIFs: 24   (req: <= 3)
Antibodies: 403   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 414.15   (req: >= 5)
Gene RIFs: 24   (req: > 3)
Antibodies: 403   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 31
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (107)
CLN3
Tbio
Novelty:  0.00242393
Score:  0.907
Data Source:  STRINGDB
MECR
Tbio
Family:  Enzyme
Novelty:  0.01395965
Score:  0.905
Data Source:  STRINGDB
PPT2
Tbio
Family:  Enzyme
Novelty:  0.00829249
Score:  0.861
Data Source:  STRINGDB
LYPLA1
Tchem
Family:  Enzyme
Novelty:  0.01217068
Score:  0.838
Data Source:  STRINGDB
CLN5
Tbio
Novelty:  0.01124343
Score:  0.835
Data Source:  STRINGDB
CLN6
Tbio
Novelty:  0.01095683
Score:  0.832
Data Source:  STRINGDB
CLN8
Tbio
Novelty:  0.01721625
Score:  0.818
Data Source:  STRINGDB
LYPLA2
Tchem
Family:  Enzyme
Novelty:  0.05436006
Score:  0.77
Data Source:  STRINGDB
TPP1
Tbio
Family:  Enzyme
Novelty:  0.00590008
Score:  0.768
Data Source:  STRINGDB
SGSH
Tbio
Family:  Enzyme
Novelty:  0.00670111
Score:  0.766
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Fatty acid metabolism (R-HSA-8978868)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Fatty acid metabolism
Reactome
Fatty acyl-CoA biosynthesis
Reactome
Metabolism
Reactome
Metabolism of lipids
Name
Explore in Pharos
Explore in Source
Fatty acid metabolism
Fatty acyl-CoA biosynthesis
Metabolism
Metabolism of lipids
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
1
1
33.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
platelet count
1
33.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
palmitoyl-protein thioesterase 1
VGNC:6966
456789
Macaque
palmitoyl-protein thioesterase 1
693377
Mouse
MGI:1298204
19063
Rat
RGD:61994
29411
Dog
palmitoyl-protein thioesterase 1
VGNC:44929
475316
Species
Name
OMA
EggNOG
Inparanoid
Chimp
palmitoyl-protein thioesterase 1
Macaque
palmitoyl-protein thioesterase 1
Mouse
Rat
Dog
palmitoyl-protein thioesterase 1
Publication Statistics
PubMed Score 414.15
PubMed score by year
PubTator Score 215.33
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title