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Tbio
BCAM
Basal cell adhesion molecule

Protein Summary
Description
Laminin alpha-5 receptor. May mediate intracellular signaling. This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270233
  • ENSP00000270233
  • ENSG00000187244

Symbol
  • LU
  • MSK19
  • AU
  • LU
  • CD239
  • MSK19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
transcription factor perturbation
0.74
protein domain
0.73
tissue sample
0.72
gene perturbation
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.13   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 67.13   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
10
0
4.5
96.9
low density lipoprotein cholesterol measurement
3
3
4
96.3
family history of Alzheimer’s disease
1
7
0
8.7
94.4
C-reactive protein measurement
1
1
1
94
total cholesterol measurement
1
1
2
41.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
4.5
96.9
low density lipoprotein cholesterol measurement
4
96.3
family history of Alzheimer’s disease
0
8.7
94.4
C-reactive protein measurement
1
94
total cholesterol measurement
2
41.6
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (52)
1 – 10 of 52
LAMA4
Tbio
Novelty: 0.01288371
p_int: 0.999999925
p_ni: 7.4e-8
Score: 0.252
Data Source: BioPlex,STRINGDB
ZSWIM2
Tbio
Family: Enzyme
Novelty: 0.02135835
p_int: 0.999984337
p_ni: 0.000015658
p_wrong: 5e-9
Score: 0.189
Data Source: BioPlex,STRINGDB
ARNTL
Tbio
Family: TF
Novelty: 0.00102829
p_int: 0.999873472
p_ni: 0.000126528
Score: 0.189
Data Source: BioPlex,STRINGDB
CLEC4A
Tbio
Novelty: 0.01821643
p_int: 0.999647758
p_ni: 0.000352207
p_wrong: 3.5e-8
Data Source: BioPlex
EPHA7
Tchem
Family: Kinase
Novelty: 0.01065563
p_int: 0.999419384
p_ni: 0.000580616
Data Source: BioPlex
CTLA4
Tclin
Novelty: 0.00012781
p_int: 0.998282818
p_ni: 0.001717172
p_wrong: 1e-8
Data Source: BioPlex
UPK2
Tbio
Novelty: 0.01066132
p_int: 0.997637444
p_ni: 0.002350396
p_wrong: 0.00001216
Data Source: BioPlex
ATP6V0A1
Tbio
Family: Enzyme
Novelty: 0.02009317
p_int: 0.994972939
p_ni: 0.005027061
Data Source: BioPlex
TMEM11
Tbio
Novelty: 0.00067837
p_int: 0.993520126
p_ni: 0.006447687
p_wrong: 0.000032187
Data Source: BioPlex
LAMA5
Tbio
Novelty: 0.02247145
p_int: 0.993022444
p_ni: 0.0069775
p_wrong: 5.6e-8
Score: 0.727
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  67.13

PubMed score by year
PubTator Score  127.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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