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Tbio
BCAM
Basal cell adhesion molecule

Protein Summary
Description
Laminin alpha-5 receptor. May mediate intracellular signaling. This gene encodes Lutheran blood group glycoprotein, a member of the immunoglobulin superfamily and a receptor for the extracellular matrix protein, laminin. The protein contains five extracellular immunoglobulin domains, a single transmembrane domain, and a short C-terminal cytoplasmic tail. This protein may play a role in epithelial cell cancer and in vaso-occlusion of red blood cells in sickle cell disease. Polymorphisms in this gene define some of the antigens in the Lutheran system and also the Auberger system. Inactivating variants of this gene result in the recessive Lutheran null phenotype, Lu(a-b-), of the Lutheran blood group. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000270233
  • ENSP00000270233
  • ENSG00000187244

Symbol
  • LU
  • MSK19
  • AU
  • LU
  • CD239
  • MSK19
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
histone modification site profile
0.82
transcription factor perturbation
0.74
protein domain
0.73
tissue sample
0.72
gene perturbation
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.39   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 354   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 131.39   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 354   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (52)
LAMA4
Tbio
Novelty:  0.01288371
p_int:  0.999999925
p_ni:  7.4e-8
Score:  0.252
Data Source:  BioPlex,STRINGDB
ZSWIM2
Tbio
Family:  Enzyme
Novelty:  0.02135835
p_int:  0.999984337
p_ni:  0.000015658
p_wrong:  5e-9
Score:  0.189
Data Source:  BioPlex,STRINGDB
ARNTL
Tbio
Family:  TF
Novelty:  0.00102829
p_int:  0.999873472
p_ni:  0.000126528
Score:  0.189
Data Source:  BioPlex,STRINGDB
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.999647758
p_ni:  0.000352207
p_wrong:  3.5e-8
Data Source:  BioPlex
EPHA7
Tchem
Family:  Kinase
Novelty:  0.01065563
p_int:  0.999419384
p_ni:  0.000580616
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.998282818
p_ni:  0.001717172
p_wrong:  1e-8
Data Source:  BioPlex
UPK2
Tbio
Novelty:  0.01066132
p_int:  0.997637444
p_ni:  0.002350396
p_wrong:  0.00001216
Data Source:  BioPlex
ATP6V0A1
Tbio
Family:  Enzyme
Novelty:  0.02009317
p_int:  0.994972939
p_ni:  0.005027061
Data Source:  BioPlex
TMEM11
Tbio
Novelty:  0.00067837
p_int:  0.993520126
p_ni:  0.006447687
p_wrong:  0.000032187
Data Source:  BioPlex
LAMA5
Tbio
Novelty:  0.02247145
p_int:  0.993022444
p_ni:  0.0069775
p_wrong:  5.6e-8
Score:  0.727
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (0)
No pathways found
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (188)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
121
90
397
7.4
100
C-reactive protein measurement
18
55
74
21.8
100
Alzheimer disease
29
64
2
2.8
100
high density lipoprotein cholesterol measurement
95
50
155
12
100
triglyceride measurement
72
45
133
7.2
100
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
low density lipoprotein cholesterol measurement
397
7.4
100
C-reactive protein measurement
74
21.8
100
Alzheimer disease
2
2.8
100
high density lipoprotein cholesterol measurement
155
12
100
triglyceride measurement
133
7.2
100
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
basal cell adhesion molecule
VGNC:2582
744276
Macaque
basal cell adhesion molecule (Lutheran blood group)
714568
Mouse
MGI:1929940
57278
Rat
RGD:68378
78958
Dog
basal cell adhesion molecule
VGNC:49023
484456
Species
Name
OMA
EggNOG
Inparanoid
Chimp
basal cell adhesion molecule
Macaque
basal cell adhesion molecule (Lutheran blood group)
Mouse
Rat
Dog
basal cell adhesion molecule
Publication Statistics
PubMed Score 131.39
PubMed score by year
PubTator Score 127.78
PubTator score by year
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Related Publications
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PMID
Year
Title