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Tchem
CDK9
Cyclin-dependent kinase 9

Protein Summary
Description
Protein kinase involved in the regulation of transcription. Member of the cyclin-dependent kinase pair (CDK9/cyclin-T) complex, also called positive transcription elongation factor b (P-TEFb), which facilitates the transition from abortive to productive elongation by phosphorylating the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAP II) POLR2A, SUPT5H and RDBP. This complex is inactive when in the 7SK snRNP complex form. Phosphorylates EP300, MYOD1, RPB1/POLR2A and AR, and the negative elongation factors DSIF and NELF. Regulates cytokine inducible transcription networks by facilitating promoter recognition of target transcription factors (e.g. TNF-inducible RELA/p65 activation and IL-6-inducible STAT3 signaling). Promotes RNA synthesis in genetic programs for cell growth, differentiation and viral pathogenesis. P-TEFb is also involved in cotranscriptional histone modification, mRNA processing and mRNA export. Modulates a complex network of chromatin modificatio ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373264
  • ENSP00000362361
  • ENSG00000136807

Symbol
  • CDC2L4
  • TAK
  • TAK
  • C-2k
  • CTK1
  • CDC2L4
  • PITALRE
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
molecular function
0.99
biological process
0.98
protein complex
0.95
pathway
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 524.17   (req: < 5)
Gene RIFs: 120   (req: <= 3)
Antibodies: 503   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 524.17   (req: >= 5)
Gene RIFs: 120   (req: > 3)
Antibodies: 503   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 38
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 253
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (298)
HEXIM1
Tbio
Novelty:  0.0142443
p_int:  0.999999816
p_ni:  1.84e-7
Score:  0.98
Data Source:  BioPlex,STRINGDB
CCNT1
Tchem
Novelty:  0.00526848
p_int:  0.999999749
p_ni:  2.51e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
HEXIM2
Tbio
Novelty:  0.14814693
p_int:  0.999999569
p_ni:  4.31e-7
Score:  0.953
Data Source:  BioPlex,STRINGDB
HSP90AB3P
Tdark
p_int:  0.999999548
p_ni:  4.52e-7
Data Source:  BioPlex
CCNT2
Tbio
Novelty:  0.04593314
p_int:  0.99999954
p_ni:  4.6e-7
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
HSP90AB4P
Tdark
p_int:  0.999999442
p_ni:  5.58e-7
Data Source:  BioPlex
AFF4
Tbio
Family:  TF
Novelty:  0.02113896
p_int:  0.999999437
p_ni:  5.63e-7
Score:  0.999
Data Source:  BioPlex,STRINGDB
HSP90AA4P
Tdark
p_int:  0.999999258
p_ni:  7.4e-7
p_wrong:  3e-9
Data Source:  BioPlex
AFF1
Tbio
Family:  TF
Novelty:  0.00094358
p_int:  0.999997628
p_ni:  0.000001246
p_wrong:  0.000001126
Score:  0.875
Data Source:  BioPlex,STRINGDB
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.999990428
p_ni:  0.000009572
Score:  0.416
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (60)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 33
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
ESR-mediated signaling
Reactome
Estrogen-dependent gene expression
Reactome
Formation of HIV elongation complex in the absence of HIV Tat
Reactome
Formation of HIV-1 elongation complex containing HIV-1 Tat
Name
Explore in Pharos
Explore in Source
Disease
ESR-mediated signaling
Estrogen-dependent gene expression
Formation of HIV elongation complex in the absence of HIV Tat
Formation of HIV-1 elongation complex containing HIV-1 Tat
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (48)
Find Similar Targets
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
3
3
93.9
hematocrit
3
2
3
86.8
monocyte percentage of leukocytes
2
2
2
72.8
neutrophil percentage of leukocytes
1
1
1
54.4
granulocyte percentage of myeloid white cells
1
1
1
45.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hemoglobin measurement
3
93.9
hematocrit
3
86.8
monocyte percentage of leukocytes
2
72.8
neutrophil percentage of leukocytes
1
54.4
granulocyte percentage of myeloid white cells
1
45.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 9
VGNC:8807
464755
Mouse
MGI:1328368
107951
Rat
RGD:1359638
362110
Dog
cyclin dependent kinase 9
VGNC:39062
100855805
Horse
cyclin dependent kinase 9
VGNC:16357
100070437
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 9
Mouse
Rat
Dog
cyclin dependent kinase 9
Horse
cyclin dependent kinase 9
Publication Statistics
PubMed Score 524.17
PubMed score by year
PubTator Score 428.30
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title