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Tbio
TOB1
Protein Tob1

Protein Summary
Description
Anti-proliferative protein; the function is mediated by association with deadenylase subunits of the CCR4-NOT complex (PubMed:8632892, PubMed:23236473). Mediates CPEB3-accelerated mRNA deadenylation by binding to CPEB3 and recruiting CNOT7 which leads to target mRNA deadenylation and decay (PubMed:21336257). This gene encodes a member of the transducer of erbB-2 /B-cell translocation gene protein family. Members of this family are anti-proliferative factors that have the potential to regulate cell growth. The encoded protein may function as a tumor suppressor. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000268957
  • ENSP00000268957
  • ENSG00000141232
  • ENST00000499247
  • ENSP00000427695

Symbol
  • TOB
  • TROB1
  • TOB
  • TROB
  • APRO5
  • APRO6
  • PIG49
  • TROB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.98
PubMedID
0.95
transcription factor binding site profile
0.94
transcription factor perturbation
0.91
biological process
0.86


Related Tools
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.09   (req: < 5)
Gene RIFs: 32   (req: <= 3)
Antibodies: 256   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 71.09   (req: >= 5)
Gene RIFs: 32   (req: > 3)
Antibodies: 256   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
transducer of ERBB2, 1
VGNC:14208
468406
Macaque
transducer of ERBB2, 1
706873
Mouse
MGI:1349721
22057
Rat
RGD:621126
170842
Dog
transducer of ERBB2, 1
VGNC:49663
100683517
Species
Name
OMA
EggNOG
Inparanoid
Chimp
transducer of ERBB2, 1
Macaque
transducer of ERBB2, 1
Mouse
Rat
Dog
transducer of ERBB2, 1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P50616-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (46)
1 – 10 of 46
CNOT6
Tbio
Novelty: 0.03605299
p_int: 0.999999939
p_ni: 6.1e-8
Score: 0.983
Data Source: BioPlex,STRINGDB
CNOT6L
Tbio
Novelty: 0.06038336
p_int: 0.999999536
p_ni: 4.63e-7
p_wrong: 1e-9
Score: 0.987
Data Source: BioPlex,STRINGDB
CNOT2
Tbio
Novelty: 0.01886737
p_int: 0.999997014
p_ni: 0.000002986
Score: 0.963
Data Source: BioPlex,STRINGDB
TNKS1BP1
Tbio
Family: Enzyme
Novelty: 0.21682007
p_int: 0.999994502
p_ni: 0.000005498
Score: 0.976
Data Source: BioPlex,STRINGDB
CNOT7
Tchem
Novelty: 0.04551853
p_int: 0.999991842
p_ni: 0.000008153
p_wrong: 4e-9
Score: 0.999
Data Source: BioPlex,STRINGDB
CNOT3
Tbio
Novelty: 0.02463568
p_int: 0.999991484
p_ni: 0.000008516
Score: 0.978
Data Source: BioPlex,STRINGDB
CNOT9
Tbio
Novelty: 0.05592835
p_int: 0.999978319
p_ni: 0.000021681
Score: 0.964
Data Source: BioPlex,STRINGDB
CNOT11
Tbio
Novelty: 0.01687183
p_int: 0.999957788
p_ni: 0.000042212
Score: 0.984
Data Source: BioPlex,STRINGDB
CNOT8
Tbio
Novelty: 0.01700084
p_int: 0.999902366
p_ni: 0.000097606
p_wrong: 2.8e-8
Score: 0.993
Data Source: BioPlex,STRINGDB
CNOT1
Tbio
Novelty: 0.00362753
p_int: 0.999892234
p_ni: 0.000107766
Score: 0.982
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  71.09

PubMed score by year
PubTator Score  127.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer