Protein Summary
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit ...more
- ENST00000256443
- ENSP00000256443
- ENSG00000134058
- ENST00000615305
- ENSP00000479116
- ENSG00000277273
- CAK
- CAK1
- CDKN7
- MO15
- STK1
- CAK
- CAK1
- HCAK
- MO15
- STK1
- CDKN7
- p39MO15
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
molecular function | 1 | ||
small molecule | 1 | ||
biological process | 0.95 | ||
hub protein | 0.88 | ||
transcription factor perturbation | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 305.05 (req: < 5)
Gene RIFs: 42 (req: <= 3)
Antibodies: 756 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 305.05 (req: >= 5)
Gene RIFs: 42 (req: > 3)
Antibodies: 756 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 56
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)

The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (56)
Protein-Protein Interactions (345)
MNAT1
Family: Enzyme
Novelty: 0.02484936
p_int: 0.999999996
p_ni: 4e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PI4KB
Family: Kinase
Novelty: 0.00856875
p_int: 0.99999293
p_ni: 0.00000707
Score: 0.215
Data Source: BioPlex,STRINGDB
TBC1D32
Novelty: 0.25744084
p_int: 0.999839557
p_ni: 0.000160425
p_wrong: 1.8e-8
Score: 0.362
Data Source: BioPlex,STRINGDB
CDK20
Family: Kinase
Novelty: 0.01176977
p_int: 0.999814764
p_ni: 0.000171931
p_wrong: 0.000013304
Score: 0.291
Data Source: BioPlex,STRINGDB
FKBP5
Family: Enzyme
Novelty: 0.00214511
p_int: 0.999788021
p_ni: 0.000211979
Score: 0.164
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (78)
Reactome (61)
KEGG (3)
PathwayCommons (8)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Cyclin A/B1/B2 associated events during G2/M transition | ||||
Reactome | Cyclin A:Cdk2-associated events at S phase entry | ||||
Reactome | Cyclin D associated events in G1 | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Cyclin A/B1/B2 associated events during G2/M transition | ||||
Cyclin A:Cdk2-associated events at S phase entry | ||||
Cyclin D associated events in G1 | ||||
Viral Interactions (0)
Gene Ontology Terms (35)
Functions (10)
Components (7)
Processes (18)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Traceable Author Statement (TAS) | Reactome | |||
Traceable Author Statement (TAS) | ProtInc | |||
Traceable Author Statement (TAS) | Reactome | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
neutrophil count | 3 | 3 | 3 | 94.3 | |||||
myeloid white cell count | 2 | 2 | 2 | 90.1 | |||||
leukocyte count | 2 | 2 | 2 | 86.1 | |||||
neutrophil percentage of leukocytes | 2 | 2 | 2 | 83.7 | |||||
sum of basophil and neutrophil counts | 1 | 1 | 1 | 64.9 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
neutrophil count | 3 | 94.3 | |||||
myeloid white cell count | 2 | 90.1 | |||||
leukocyte count | 2 | 86.1 | |||||
neutrophil percentage of leukocytes | 2 | 83.7 | |||||
sum of basophil and neutrophil counts | 1 | 64.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (17)
1 – 5 of 17
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | cyclin dependent kinase 7 | VGNC:11877 | 462378 | |||||
Macaque | cyclin dependent kinase 7 | 699871 | ||||||
Mouse | MGI:102956 | 12572 | ||||||
Rat | RGD:621124 | 171150 | ||||||
Dog | cyclin dependent kinase 7 | VGNC:39060 | 608441 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | cyclin dependent kinase 7 | |||||
Macaque | cyclin dependent kinase 7 | |||||
Mouse | ||||||
Rat | ||||||
Dog | cyclin dependent kinase 7 | |||||
Publication Statistics
PubMed Score 305.05
PubMed score by year
PubTator Score 203.14
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (130)
GeneRif Annotations (42)
Items per page:
0 of 0
PMID | Year | Title |
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