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Tchem
CDK7
Cyclin-dependent kinase 7

Protein Summary
Description
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256443
  • ENSP00000256443
  • ENSG00000134058
  • ENST00000615305
  • ENSP00000479116
  • ENSG00000277273

Symbol
  • CAK
  • CAK1
  • CDKN7
  • MO15
  • STK1
  • CAK
  • CAK1
  • HCAK
  • MO15
  • STK1
  • CDKN7
  • p39MO15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
small molecule
1
biological process
0.95
hub protein
0.88
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 305.05   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 756   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 305.05   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 756   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 56
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (345)
CCNH
Tbio
Novelty:  0.00693072
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
MNAT1
Tbio
Family:  Enzyme
Novelty:  0.02484936
p_int:  0.999999996
p_ni:  4e-9
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
HSP90AB3P
Tdark
p_int:  0.999996978
p_ni:  0.00000302
p_wrong:  1e-9
Data Source:  BioPlex
HSP90AA4P
Tdark
p_int:  0.999995149
p_ni:  0.000004819
p_wrong:  3.1e-8
Data Source:  BioPlex
HSP90AB4P
Tdark
p_int:  0.999993981
p_ni:  0.000006018
p_wrong:  1e-9
Data Source:  BioPlex
PI4KB
Tchem
Family:  Kinase
Novelty:  0.00856875
p_int:  0.99999293
p_ni:  0.00000707
Score:  0.215
Data Source:  BioPlex,STRINGDB
TBC1D32
Tbio
Novelty:  0.25744084
p_int:  0.999839557
p_ni:  0.000160425
p_wrong:  1.8e-8
Score:  0.362
Data Source:  BioPlex,STRINGDB
CDK20
Tbio
Family:  Kinase
Novelty:  0.01176977
p_int:  0.999814764
p_ni:  0.000171931
p_wrong:  0.000013304
Score:  0.291
Data Source:  BioPlex,STRINGDB
FKBP5
Tchem
Family:  Enzyme
Novelty:  0.00214511
p_int:  0.999788021
p_ni:  0.000211979
Score:  0.164
Data Source:  BioPlex,STRINGDB
HSP90AA5P
Tdark
p_int:  0.998788403
p_ni:  0.001211597
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (78)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 61
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin A/B1/B2 associated events during G2/M transition
Reactome
Cyclin A:Cdk2-associated events at S phase entry
Reactome
Cyclin D associated events in G1
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin A/B1/B2 associated events during G2/M transition
Cyclin A:Cdk2-associated events at S phase entry
Cyclin D associated events in G1
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (35)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
3
3
94.3
myeloid white cell count
2
2
2
90.1
leukocyte count
2
2
2
86.1
neutrophil percentage of leukocytes
2
2
2
83.7
sum of basophil and neutrophil counts
1
1
1
64.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
neutrophil count
3
94.3
myeloid white cell count
2
90.1
leukocyte count
2
86.1
neutrophil percentage of leukocytes
2
83.7
sum of basophil and neutrophil counts
1
64.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 7
VGNC:11877
462378
Macaque
cyclin dependent kinase 7
699871
Mouse
MGI:102956
12572
Rat
RGD:621124
171150
Dog
cyclin dependent kinase 7
VGNC:39060
608441
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cyclin dependent kinase 7
Macaque
cyclin dependent kinase 7
Mouse
Rat
Dog
cyclin dependent kinase 7
Publication Statistics
PubMed Score 305.05
PubMed score by year
PubTator Score 203.14
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title