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Tchem
CDK7
Cyclin-dependent kinase 7

Protein Summary
Description
Serine/threonine kinase involved in cell cycle control and in RNA polymerase II-mediated RNA transcription. Cyclin-dependent kinases (CDKs) are activated by the binding to a cyclin and mediate the progression through the cell cycle. Each different complex controls a specific transition between 2 subsequent phases in the cell cycle. Required for both activation and complex formation of CDK1/cyclin-B during G2-M transition, and for activation of CDK2/cyclins during G1-S transition (but not complex formation). CDK7 is the catalytic subunit of the CDK-activating kinase (CAK) complex. Phosphorylates SPT5/SUPT5H, SF1/NR5A1, POLR2A, p53/TP53, CDK1, CDK2, CDK4, CDK6 and CDK11B/CDK11. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation, thus regulating cell cycle progression. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256443
  • ENSP00000256443
  • ENSG00000134058
  • ENST00000615305
  • ENSP00000479116
  • ENSG00000277273

Symbol
  • CAK
  • CAK1
  • CDKN7
  • MO15
  • STK1
  • CAK
  • CAK1
  • HCAK
  • MO15
  • STK1
  • CDKN7
  • p39MO15
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
1
small molecule
1
biological process
0.95
hub protein
0.88
transcription factor perturbation
0.88


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.91   (req: < 5)
Gene RIFs: 42   (req: <= 3)
Antibodies: 756   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 344.91   (req: >= 5)
Gene RIFs: 42   (req: > 3)
Antibodies: 756   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 59
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1