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Tbio
TNFSF10
Tumor necrosis factor ligand superfamily member 10

Protein Summary
Description
Cytokine that binds to TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and possibly also to TNFRSF11B/OPG (PubMed:26457518, PubMed:10549288). Induces apoptosis. Its activity may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4 and TNFRSF11B/OPG that cannot induce apoptosis. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The bind ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000241261
  • ENSP00000241261
  • ENSG00000121858
  • ENST00000420541
  • ENSP00000389931

Symbol
  • APO2L
  • TRAIL
  • TL2
  • APO2L
  • CD253
  • TRAIL
  • Apo-2L
  • TNLG6A
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
gene perturbation
1
virus perturbation
1
chemical
0.98
kinase perturbation
0.95


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 846.99   (req: < 5)
Gene RIFs: 744   (req: <= 3)
Antibodies: 1202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 846.99   (req: >= 5)
Gene RIFs: 744   (req: > 3)
Antibodies: 1202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
79.7
TNF-related apoptosis-inducing ligand measurement
1
2
2
79.5
triglyceride measurement
2
2
2
60.8
osteoprotegerin measurement
1
1
1
55.3
sex hormone-binding globulin measurement
1
1
1
47.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
79.7
TNF-related apoptosis-inducing ligand measurement
2
79.5
triglyceride measurement
2
60.8
osteoprotegerin measurement
1
55.3
sex hormone-binding globulin measurement
1
47.9
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
TNF superfamily member 10
VGNC:8015
460852
Macaque
TNF superfamily member 10
694451
Mouse
MGI:107414
22035
Rat
RGD:628734
246775
Dog
TNF superfamily member 10
VGNC:47669
100174780
Species
Name
OMA
EggNOG
Inparanoid
Chimp
TNF superfamily member 10
Macaque
TNF superfamily member 10
Mouse
Rat
Dog
TNF superfamily member 10
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P50591-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (93)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
CASP8 activity is inhibited
Reactome
Caspase activation via Death Receptors in the presence of ligand
Reactome
Caspase activation via extrinsic apoptotic signalling pathway
Reactome
Death Receptor Signalling
Name
Explore in Pharos
Explore in Source
Apoptosis
CASP8 activity is inhibited
Caspase activation via Death Receptors in the presence of ligand
Caspase activation via extrinsic apoptotic signalling pathway
Death Receptor Signalling
Gene Ontology Terms (24)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (165)
1 – 10 of 165
RMC1
Tbio
Novelty: 0.02804116
p_int: 0.999999887
p_ni: 1.11e-7
p_wrong: 2e-9
Data Source: BioPlex
CCZ1
Tbio
Novelty: 0.09830652
p_int: 0.980323194
p_ni: 0.019676806
Data Source: BioPlex
NOMO1
Tbio
Novelty: 0.13625697
p_int: 0.904816173
p_ni: 0.095183827
Data Source: BioPlex
STAG1
Tbio
Novelty: 0.00122511
p_int: 0.892270823
p_ni: 0.107316194
p_wrong: 0.000412983
Data Source: BioPlex
HSPA5
Tchem
Novelty: 0.00043424
p_int: 0.817623424
p_ni: 0.182376576
Score: 0.238
Data Source: BioPlex,STRINGDB
TNFRSF10C
Tbio
Novelty: 0.0088942
Score: 0.999
Data Source: STRINGDB
TNFRSF10B
Tbio
Novelty: 0.00054433
Score: 0.999
Data Source: Reactome,STRINGDB
TNFRSF10A
Tchem
Novelty: 0.0003383
Score: 0.999
Data Source: Reactome,STRINGDB
CASP8
Tchem
Family: Enzyme
Novelty: 0.00024321
Score: 0.993
Data Source: Reactome,STRINGDB
FADD
Tbio
Novelty: 0.00137968
Score: 0.984
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  846.99

PubMed score by year
PubTator Score  4318.85

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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