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Tbio
NUDT2
Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Protein Classes
Protein Summary
Description
Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000346365
  • ENSP00000344187
  • ENSG00000164978
  • ENST00000379155
  • ENSP00000368452
  • ENST00000379158
  • ENSP00000368455
  • ENST00000618590
  • ENSP00000482384

Symbol
  • APAH1
  • APAH1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.94
histone modification site profile
0.86
kinase perturbation
0.71
tissue sample
0.65
cell type or tissue
0.64


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.38   (req: < 5)
Gene RIFs: 8   (req: <= 3)
Antibodies: 187   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.38   (req: >= 5)
Gene RIFs: 8   (req: > 3)
Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P50583-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
Protein-Protein Interactions (155)
1 – 10 of 155
ANKRD22
Tdark
Novelty: 0.28856283
p_int: 0.962055064
p_ni: 0.036553653
p_wrong: 0.001391283
Data Source: BioPlex
ITPA
Tbio
Family: Enzyme
Novelty: 0.00235169
Score: 0.923
Data Source: STRINGDB
ENTPD3
Tbio
Family: Enzyme
Novelty: 0.01673548
Score: 0.917
Data Source: STRINGDB
CTPS1
Tbio
Family: Enzyme
Novelty: 0.00911596
Score: 0.911
Data Source: STRINGDB
CTPS2
Tbio
Family: Enzyme
Novelty: 0.06147923
Score: 0.909
Data Source: STRINGDB
NME2
Tbio
Family: Kinase
Novelty: 0.00257937
Score: 0.906
Data Source: STRINGDB
AK9
Tbio
Family: Kinase
Novelty: 0.06306357
Score: 0.906
Data Source: STRINGDB
NME3
Tbio
Family: Kinase
Novelty: 0.05947052
Score: 0.905
Data Source: STRINGDB
PKM
Tchem
Family: Kinase
Novelty: 0.00076567
Score: 0.905
Data Source: STRINGDB
NME6
Tbio
Family: Kinase
Novelty: 0.12087274
Score: 0.905
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.38

PubMed score by year
PubTator Score  12.55

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer