Tbio NUDT2 Bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

Protein Summary

Description

Asymmetrically hydrolyzes Ap4A to yield AMP and ATP. Plays a major role in maintaining homeostasis. This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]

Uniprot Accession IDs

• P50583
• D3DRM0
• Q5T589

Gene Name

• NUDT2

Ensembl ID

• ENST00000346365
• ENSP00000344187
• ENSG00000164978
• ENST00000379155
• ENSP00000368452
• ENST00000379158
• ENSP00000368455
• ENST00000618590
• ENSP00000482384

Symbol

• APAH1
• APAH1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.94
histone modification site profile	0.86
kinase perturbation	0.71
tissue sample	0.65
cell type or tissue	0.64

Protein Classes

PANTHER Classes

Protein / Hydrolase / Bis(5'-nucleosyl)-tetraphosphatase [Asymmetrical]

DTO Classes

Protein / Enzyme / Hydrolase / Bis(5'-nucleosyl)-tetraphosphatase [Asymmetrical]

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.99   (req: < 5)

Gene RIFs: 10   (req: <= 3)

Antibodies: 187   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 53.99   (req: >= 5)

Gene RIFs: 10   (req: > 3)

Antibodies: 187   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0