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Tchem
METAP2
Methionine aminopeptidase 2

Protein Summary
Description
Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased e ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000261220
  • ENSP00000261220
  • ENSG00000111142
  • ENST00000323666
  • ENSP00000325312
  • ENST00000546753
  • ENSP00000448169

Symbol
  • MNPEP
  • P67EIF2
  • MAP2
  • MNPEP
  • p67eIF2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
kinase perturbation
0.88
disease perturbation
0.87
virus perturbation
0.83
drug
0.79


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.68   (req: < 5)
Gene RIFs: 22   (req: <= 3)
Antibodies: 248   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.68   (req: >= 5)
Gene RIFs: 22   (req: > 3)
Antibodies: 248   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 536
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
1
2
64
reticulocyte count
1
1
1
44
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
2
64
reticulocyte count
1
44
Orthologs (18)
1 – 5 of 18
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
methionyl aminopeptidase 2
VGNC:13217
452141
Macaque
methionyl aminopeptidase 2
712400
Mouse
MGI:1929701
56307
Rat
RGD:70995
64370
Dog
methionyl aminopeptidase 2
VGNC:43168
475429
Species
Name
OMA
EggNOG
Inparanoid
Chimp
methionyl aminopeptidase 2
Macaque
methionyl aminopeptidase 2
Mouse
Rat
Dog
methionyl aminopeptidase 2
Protein Structure (26 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P50579-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 26
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (7)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Signaling by GPCR
Gene Ontology Terms (13)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Inferred from Electronic Annotation (IEA)
UniProtKB-UniRule
Protein-Protein Interactions (181)
1 – 10 of 181
RARRES1
Tbio
Family: Enzyme
Novelty: 0.04701793
p_int: 0.999906182
p_ni: 0.000093818
p_wrong: 1e-9
Data Source: BioPlex
SUCLA2
Tbio
Family: Enzyme
Novelty: 0.02029861
p_int: 0.999834674
p_ni: 0.000165326
Score: 0.19
Data Source: BioPlex,STRINGDB
GPBP1L1
Tdark
Novelty: 0.69320833
p_int: 0.99982514
p_ni: 0.00017486
Data Source: BioPlex
TMEM213
Tdark
Novelty: 0.87036241
p_int: 0.999525757
p_ni: 0.000474243
Score: 0.165
Data Source: BioPlex,STRINGDB
ALDH5A1
Tclin
Family: Enzyme
Novelty: 0.00461791
p_int: 0.999013531
p_ni: 0.000986469
Data Source: BioPlex
DDX28
Tbio
Family: Enzyme
Novelty: 0.16760542
p_int: 0.998678105
p_ni: 0.001321895
Score: 0.201
Data Source: BioPlex,STRINGDB
HYOU1
Tbio
Novelty: 0.00833649
p_int: 0.998645293
p_ni: 0.001354707
Data Source: BioPlex
CCT7
Tbio
Novelty: 0.02247038
p_int: 0.997222322
p_ni: 0.002777678
Score: 0.257
Data Source: BioPlex,STRINGDB
CCT2
Tbio
Novelty: 0.01967139
p_int: 0.99718456
p_ni: 0.00281544
Score: 0.399
Data Source: BioPlex,STRINGDB
SLC25A25
Tbio
Family: Transporter
Novelty: 0.05562006
p_int: 0.990217798
p_ni: 0.009782202
Score: 0.198
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  193.68

PubMed score by year
PubTator Score  97.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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