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Tchem
DNM2
Dynamin-2

Protein Summary
Description
Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cyt ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000355667
  • ENSP00000347890
  • ENSG00000079805
  • ENST00000359692
  • ENSP00000352721
  • ENST00000389253
  • ENSP00000373905
  • ENST00000408974
  • ENSP00000386192
  • ENST00000585892
  • ENSP00000468734

Symbol
  • DYN2
  • DYN2
  • CMT2M
  • DYNII
  • LCCS5
  • CMTDI1
  • CMTDIB
  • DI-CMTB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
protein domain
1
molecular function
0.98
hub protein
0.94
biological process
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.3   (req: < 5)
Gene RIFs: 106   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.3   (req: >= 5)
Gene RIFs: 106   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (334)
DNM1
Tbio
Novelty:  0.00319082
p_int:  0.999999766
p_ni:  2.34e-7
Score:  0.905
Data Source:  BioPlex,STRINGDB
SH3D19
Tbio
Novelty:  0.05352867
p_int:  0.999991744
p_ni:  0.000006584
p_wrong:  0.000001672
Score:  0.399
Data Source:  BioPlex,STRINGDB
ACTA1
Tbio
Novelty:  0.00111813
p_int:  0.999949265
p_ni:  0.000050735
Score:  0.447
Data Source:  BioPlex,STRINGDB
GRB2
Tchem
Novelty:  0.00091605
p_int:  0.999940946
p_ni:  0.000059054
Score:  0.975
Data Source:  BioPlex,STRINGDB
DNMBP
Tbio
Novelty:  0.0533946
p_int:  0.999848614
p_ni:  0.000151222
p_wrong:  1.64e-7
Score:  0.556
Data Source:  BioPlex,STRINGDB
DNM3
Tbio
Novelty:  0.02365643
p_int:  0.999702388
p_ni:  0.00029761
p_wrong:  2e-9
Score:  0.982
Data Source:  BioPlex,STRINGDB
TMEM9
Tbio
Novelty:  0.06916197
p_int:  0.997667697
p_ni:  0.002332303
Data Source:  BioPlex
PCDHGB2
Tdark
Novelty:  1.16587709
p_int:  0.995070269
p_ni:  0.004929242
p_wrong:  4.89e-7
Data Source:  BioPlex
TYROBP
Tbio
Family:  Enzyme
Novelty:  0.00410031
p_int:  0.990984016
p_ni:  0.009015984
Data Source:  BioPlex
IKBIP
Tbio
Family:  Enzyme
Novelty:  0.18707639
p_int:  0.990725941
p_ni:  0.00927221
p_wrong:  0.00000185
Data Source:  BioPlex
Pathways (46)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 28
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Clathrin-mediated endocytosis
Reactome
Developmental Biology
Reactome
Formation of annular gap junctions
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Clathrin-mediated endocytosis
Developmental Biology
Formation of annular gap junctions
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (90)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations (null)
No disease associations found
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
3
4
4
97.2
4
2
1
1.1
96.1
low density lipoprotein cholesterol measurement
2
8
9
91.3
apolipoprotein B measurement
1
6
6
90.8
total cholesterol measurement
2
7
8
90.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
4
97.2
1
1.1
96.1
low density lipoprotein cholesterol measurement
9
91.3
apolipoprotein B measurement
6
90.8
total cholesterol measurement
8
90.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
dynamin 2
VGNC:2394
455718
Macaque
dynamin 2
713558
Mouse
MGI:109547
13430
Rat
RGD:2513
25751
Dog
dynamin 2
VGNC:40033
484949
Species
Name
OMA
EggNOG
Inparanoid
Chimp
dynamin 2
Macaque
dynamin 2
Mouse
Rat
Dog
dynamin 2
Publication Statistics
PubMed Score 450.30
PubMed score by year
PubTator Score 280.59
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title