Tchem DNM2 Dynamin-2

Protein Summary

Description

Microtubule-associated force-producing protein involved in producing microtubule bundles and able to bind and hydrolyze GTP. Plays a role in the regulation of neuron morphology, axon growth and formation of neuronal growth cones (By similarity). Plays an important role in vesicular trafficking processes, in particular endocytosis. Involved in cytokinesis (PubMed:12498685). Regulates maturation of apoptotic cell corpse-containing phagosomes by recruiting PIK3C3 to the phagosome membrane (By similarity). Dynamins represent one of the subfamilies of GTP-binding proteins. These proteins share considerable sequence similarity over the N-terminal portion of the molecule, which contains the GTPase domain. Dynamins are associated with microtubules. They have been implicated in cell processes such as endocytosis and cell motility, and in alterations of the membrane that accompany certain activities such as bone resorption by osteoclasts. Dynamins bind many proteins that bind actin and other cytoskeletal proteins. Dynamins can also self-assemble, a process that stimulates GTPase activity. Five alternatively spliced transcripts encoding different proteins have been described. Additional alternatively spliced transcripts may exist, but their full-length nature has not been determined. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P50570
• A8K1B6
• E7EV30
• E9PEQ4
• K7ESI9
• Q5I0Y0
• Q7Z5S3
• Q9UPH4

Gene Name

• DNM2

Ensembl ID

• ENST00000355667
• ENSP00000347890
• ENSG00000079805
• ENST00000359692
• ENSP00000352721
• ENST00000389253
• ENSP00000373905
• ENST00000408974
• ENSP00000386192
• ENST00000585892
• ENSP00000468734

Symbol

• DYN2
• DYN2
• CMT2M
• DYNII
• LCCS5
• CMTDI1
• CMTDIB
• DI-CMTB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein complex	1
protein domain	1
molecular function	0.98
hub protein	0.94
biological process	0.9

Protein Classes

PANTHER Classes

Protein / Hydrolase / Dynamin-2

Protein / Enzyme Modulator / G-protein / Small Gtpase / Dynamin-2

Protein / Cytoskeletal Protein / Microtubule Family Cytoskeletal Protein / Dynamin-2

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Dynamin-2

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.3   (req: < 5)

Gene RIFs: 133   (req: <= 3)

Antibodies: 213   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 450.3   (req: >= 5)

Gene RIFs: 133   (req: > 3)

Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 54

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 3

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0