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Tbio
ASCL1
Achaete-scute homolog 1

Protein Summary
Description
Transcription factor that plays a key role in neuronal differentiation: acts as a pioneer transcription factor, accessing closed chromatin to allow other factors to bind and activate neural pathways. Directly binds the E box motif (5'-CANNTG-3') on promoters and promotes transcription of neuronal genes. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Plays a role at early stages of development of specific neural lineages in most regions of the CNS, and of several lineages in the PNS. Essential for the generation of olfactory and autonomic neurons. Acts synergistically with FOXN4 to specify the identity of V2b neurons rather than V2a from bipotential p2 progenitors during spinal cord neurogenesis, probably through DLL4-NOTCH signaling activation. This gene encodes a member of the basic helix-loop-helix (BHLH) family of transcription factors. The protein ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000266744
  • ENSP00000266744
  • ENSG00000139352

Symbol
  • ASH1
  • BHLHA46
  • HASH1
  • ASH1
  • HASH1
  • MASH1
  • bHLHa46
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
molecular function
0.97
gene perturbation
0.86
PubMedID
0.86
cell line
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.66   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 486   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 412.66   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 486   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 64
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (186)
NEUROG2
Tbio
Family:  TF
Novelty:  0.00489481
Score:  0.922
Data Source:  STRINGDB
TCF4
Tbio
Family:  TF
Novelty:  0.0019718
Score:  0.918
Data Source:  STRINGDB
ID1
Tbio
Family:  TF
Novelty:  0.00151069
Score:  0.904
Data Source:  STRINGDB
POU3F2
Tbio
Family:  TF
Novelty:  0.00649458
Score:  0.895
Data Source:  STRINGDB
TCF3
Tbio
Family:  TF
Novelty:  0.00112675
Score:  0.889
Data Source:  STRINGDB
ID2
Tbio
Family:  TF
Novelty:  0.00256364
Score:  0.878
Data Source:  STRINGDB
HES5
Tbio
Family:  TF
Novelty:  0.00565225
Score:  0.869
Data Source:  STRINGDB
MYT1L
Tbio
Family:  TF
Novelty:  0.0174369
Score:  0.856
Data Source:  STRINGDB
TCF12
Tbio
Family:  TF
Novelty:  0.00381424
Score:  0.85
Data Source:  STRINGDB
OLIG2
Tbio
Family:  TF
Novelty:  0.0015221
Score:  0.848
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (67)
Find Similar Targets
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
3
4
5
91.9
blood metabolite measurement
2
2
2
58.2
IGF-1 measurement
1
1
1
35
appendicular lean mass
1
1
1
21.5
C-reactive protein measurement
1
1
1
14
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
amino acid measurement
5
91.9
blood metabolite measurement
2
58.2
IGF-1 measurement
1
35
appendicular lean mass
1
21.5
C-reactive protein measurement
1
14
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
achaete-scute family bHLH transcription factor 1
698820
Mouse
MGI:96919
17172
Rat
RGD:71010
64186
Dog
achaete-scute family bHLH transcription factor 1
VGNC:38173
482628
Cow
achaete-scute family bHLH transcription factor 1
VGNC:26206
540473
Species
Name
OMA
EggNOG
Inparanoid
Macaque
achaete-scute family bHLH transcription factor 1
Mouse
Rat
Dog
achaete-scute family bHLH transcription factor 1
Cow
achaete-scute family bHLH transcription factor 1
Publication Statistics
PubMed Score 412.66
PubMed score by year
PubTator Score 234.67
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title