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Tbio
VASP
Vasodilator-stimulated phosphoprotein

Protein Summary
Description
Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal ad ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245932
  • ENSP00000245932
  • ENSG00000125753
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase
0.97
biological term
0.91
transcription factor
0.91
transcription factor binding site profile
0.86
cellular component
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2380.38   (req: < 5)
Gene RIFs: 92   (req: <= 3)
Antibodies: 1002   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2380.38   (req: >= 5)
Gene RIFs: 92   (req: > 3)
Antibodies: 1002   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
3
4
6
91.1
apolipoprotein B measurement
1
3
3
84.3
C-reactive protein measurement
2
3
3
71.8
low density lipoprotein cholesterol measurement
1
2
2
68
total cholesterol measurement
1
1
1
12.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
6
91.1
apolipoprotein B measurement
3
84.3
C-reactive protein measurement
3
71.8
low density lipoprotein cholesterol measurement
2
68
total cholesterol measurement
1
12.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
vasodilator stimulated phosphoprotein
716022
Mouse
MGI:109268
22323
Rat
RGD:1311542
361517
Dog
vasodilator stimulated phosphoprotein
403936
Horse
vasodilator stimulated phosphoprotein
VGNC:24885
100070851
Species
Name
OMA
EggNOG
Inparanoid
Macaque
vasodilator stimulated phosphoprotein
Mouse
Rat
Dog
vasodilator stimulated phosphoprotein
Horse
vasodilator stimulated phosphoprotein
Protein Structure (7 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P50552-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (135)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Axon guidance
Reactome
Cell junction organization
Reactome
Cell-Cell communication
Reactome
Cell-extracellular matrix interactions
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Axon guidance
Cell junction organization
Cell-Cell communication
Cell-extracellular matrix interactions
Gene Ontology Terms (18)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (194)
1 – 10 of 194
EVL
Tbio
Novelty:  0.03533257
p_int:  1
Score:  0.999
Data Source:  BioPlex,STRINGDB
TTC23L
Tdark
Novelty:  0.36199095
p_int:  0.999989867
p_ni:  0.000010133
Score:  0.234
Data Source:  BioPlex,STRINGDB
ZYX
Tbio
Novelty:  0.00375452
p_int:  0.999989557
p_ni:  0.000010443
Score:  0.998
Data Source:  BioPlex,STRINGDB
TEAD4
Tchem
Family:  TF
Novelty:  0.0114979
p_int:  0.999984492
p_ni:  0.000015508
Score:  0.173
Data Source:  BioPlex,STRINGDB
ENAH
Tbio
Novelty:  0.02329247
p_int:  0.999853621
p_ni:  0.000146379
Score:  0.999
Data Source:  BioPlex,STRINGDB
FBLIM1
Tbio
Novelty:  0.0332985
p_int:  0.999612914
p_ni:  0.000387085
Score:  0.975
Data Source:  BioPlex,Reactome,STRINGDB
RAB30
Tbio
Family:  Enzyme
Novelty:  0.1262404
p_int:  0.977645886
p_ni:  0.022350103
p_wrong:  0.000004012
Data Source:  BioPlex
ABI1
Tbio
Novelty:  0.00796638
p_int:  0.918038313
p_ni:  0.081887159
p_wrong:  0.000074528
Score:  0.801
Data Source:  BioPlex,STRINGDB
PFN2
Tbio
Novelty:  0.00605366
p_int:  0.863762057
p_ni:  0.136237943
Score:  0.992
Data Source:  BioPlex,STRINGDB
GTPBP1
Tbio
Novelty:  0.00160825
p_int:  0.844017576
p_ni:  0.155982424
Score:  0.221
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  2380.38

PubMed score by year
PubTator Score  528

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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