Tbio VASP Vasodilator-stimulated phosphoprotein

Protein Summary

Description

Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation. Vasodilator-stimulated phosphoprotein (VASP) is a member of the Ena-VASP protein family. Ena-VASP family members contain an EHV1 N-terminal domain that binds proteins containing E/DFPPPPXD/E motifs and targets Ena-VASP proteins to focal adhesions. In the mid-region of the protein, family members have a proline-rich domain that binds SH3 and WW domain-containing proteins. Their C-terminal EVH2 domain mediates tetramerization and binds both G and F actin. VASP is associated with filamentous actin formation and likely plays a widespread role in cell adhesion and motility. VASP may also be involved in the intracellular signaling pathways that regulate integrin-extracellular matrix interactions. VASP is regulated by the cyclic nucleotide-dependent kinases PKA and PKG. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P50552
• B2RBT9
• Q6PIZ1
• Q93035
• VASP

Gene Name

• VASP

Ensembl ID

• ENST00000245932
• ENSP00000245932
• ENSG00000125753

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase	0.97
biological term	0.91
transcription factor	0.91
transcription factor binding site profile	0.86
cellular component	0.82

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2380.38   (req: < 5)

Gene RIFs: 92   (req: <= 3)

Antibodies: 1002   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2380.38   (req: >= 5)

Gene RIFs: 92   (req: > 3)

Antibodies: 1002   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (5)

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	3	4	6		91.1
apolipoprotein B measurement	EFO_0004615	1	3	3		84.3
C-reactive protein measurement	EFO_0004458	2	3	3		71.8
low density lipoprotein cholesterol measurement	EFO_0004611	1	2	2		68
total cholesterol measurement	EFO_0004574	1	1	1		12.2

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
heel bone mineral density	EFO_0009270	6		91.1
apolipoprotein B measurement	EFO_0004615	3		84.3
C-reactive protein measurement	EFO_0004458	3		71.8
low density lipoprotein cholesterol measurement	EFO_0004611	2		68
total cholesterol measurement	EFO_0004574	1		12.2

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Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	vasodilator stimulated phosphoprotein		716022
Mouse	vasodilator-stimulated phosphoprotein	MGI:109268	22323
Rat	vasodilator-stimulated phosphoprotein	RGD:1311542	361517
Dog	vasodilator stimulated phosphoprotein		403936
Horse	vasodilator stimulated phosphoprotein	VGNC:24885	100070851

Species	Name	OMA	EggNOG	Inparanoid
Macaque	vasodilator stimulated phosphoprotein
Mouse	vasodilator-stimulated phosphoprotein
Rat	vasodilator-stimulated phosphoprotein
Dog	vasodilator stimulated phosphoprotein
Horse	vasodilator stimulated phosphoprotein

Protein Structure (7 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P50552-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 7

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (135)

Reactome (10)

KEGG (7)

PathwayCommons (11)

WikiPathways (107)

Adaptive Immune System (R-HSA-1280218)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Adaptive Immune System	894 targets	R-HSA-1280218
Reactome	Axon guidance	533 targets	R-HSA-422475
Reactome	Cell junction organization	88 targets	R-HSA-446728
Reactome	Cell-Cell communication	121 targets	R-HSA-1500931
Reactome	Cell-extracellular matrix interactions	16 targets	R-HSA-446353

Name	Explore in Pharos	Explore in Source
Adaptive Immune System	894 targets	R-HSA-1280218
Axon guidance	533 targets	R-HSA-422475
Cell junction organization	88 targets	R-HSA-446728
Cell-Cell communication	121 targets	R-HSA-1500931
Cell-extracellular matrix interactions	16 targets	R-HSA-446353

Gene Ontology Terms (18)

Functions (4)

Components (8)

Processes (6)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
profilin binding	Inferred from Physical Interaction (IPI)	UniProtKB
cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL
actin binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW
SH3 domain binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (194)

Explore Interacting Targets

1 – 10 of 194

• See Interactions on String-DB

EVL

Tbio

Novelty:  0.03533257

p_int:  1

Score:  0.999

Data Source:  BioPlex,STRINGDB

TTC23L

Tdark

Novelty:  0.36199095

p_int:  0.999989867

p_ni:  0.000010133

Score:  0.234

Data Source:  BioPlex,STRINGDB

ZYX

Tbio

Novelty:  0.00375452

p_int:  0.999989557

p_ni:  0.000010443

Score:  0.998

Data Source:  BioPlex,STRINGDB

TEAD4

Tchem

Family:  TF

Novelty:  0.0114979

p_int:  0.999984492

p_ni:  0.000015508

Score:  0.173

Data Source:  BioPlex,STRINGDB

ENAH

Tbio

Novelty:  0.02329247

p_int:  0.999853621

p_ni:  0.000146379

Score:  0.999

Data Source:  BioPlex,STRINGDB

FBLIM1

Tbio

Novelty:  0.0332985

p_int:  0.999612914

p_ni:  0.000387085

Score:  0.975

Data Source:  BioPlex,Reactome,STRINGDB

RAB30

Tbio

Family:  Enzyme

Novelty:  0.1262404

p_int:  0.977645886

p_ni:  0.022350103

p_wrong:  0.000004012

Data Source:  BioPlex

ABI1

Tbio

Novelty:  0.00796638

p_int:  0.918038313

p_ni:  0.081887159

p_wrong:  0.000074528

Score:  0.801

Data Source:  BioPlex,STRINGDB

PFN2

Tbio

Novelty:  0.00605366

p_int:  0.863762057

p_ni:  0.136237943

Score:  0.992

Data Source:  BioPlex,STRINGDB

GTPBP1

Tbio

Novelty:  0.00160825

p_int:  0.844017576

p_ni:  0.155982424

Score:  0.221

Data Source:  BioPlex,STRINGDB

Publication Statistics

PubMed Score  2380.38

PubMed score by year

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PubTator Score  528

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
3D-structure
Acetylation
Actin-binding
Cell junction
Cell membrane
Cell projection
Coiled coil
Complete proteome
Cytoplasm
Cytoskeleton

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein B measurement
C-reactive protein measurement
heel bone mineral density
low density lipoprotein cholesterol measurement
total cholesterol measurement

MGI Phenotype Find Similar Targets

No Header	No Header
hematopoietic system phenotype
homeostasis/metabolism phenotype