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Tbio
ERF
ETS domain-containing transcription factor ERF

Protein Classes
Protein Summary
Description
Potent transcriptional repressor that binds to the H1 element of the Ets2 promoter. May regulate other genes involved in cellular proliferation. Required for extraembryonic ectoderm differentiation, ectoplacental cone cavity closure, and chorioallantoic attachment (By similarity). May be important for regulating trophoblast stem cell differentiation (By similarity). ETS2 is a transcription factor and protooncogene involved in development, apoptosis, and the regulation of telomerase. The protein encoded by this gene binds to the ETS2 promoter and is a strong repressor of ETS2 transcription. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222329
  • ENSP00000222329
  • ENSG00000105722
  • ENST00000440177
  • ENSP00000388173

Symbol
  • PE2
  • CRS4
  • PE-2
  • CHYTS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.84
ligand (protein) perturbation
0.83
transcription factor
0.68
transcription factor binding site profile
0.66
biological process
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.46   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 306   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 551.46   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 306   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
1
2
78.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
78.6
Pathways (6)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Oncogene Induced Senescence
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Oncogene Induced Senescence
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred by Curator (IC)
NTNU_SB
Protein-Protein Interactions (45)
1 – 10 of 45
ASB3
Tbio
Novelty: 0.15921018
p_int: 0.999399207
p_ni: 0.000600793
Score: 0.154
Data Source: BioPlex,STRINGDB
PRMT2
Tbio
Family: Epigenetic
Novelty: 0.04121581
p_int: 0.99527354
p_ni: 0.00472645
p_wrong: 1e-8
Score: 0.208
Data Source: BioPlex,STRINGDB
DCAF7
Tbio
Novelty: 0.02609518
p_int: 0.992608638
p_ni: 0.007391262
p_wrong: 9.9e-8
Data Source: BioPlex
CDC16
Tbio
Novelty: 0.00916715
p_int: 0.976160704
p_ni: 0.023833864
p_wrong: 0.000005432
Data Source: BioPlex
CRYBG2
Tdark
Novelty: 0.7500462
p_int: 0.972217598
p_ni: 0.027780086
p_wrong: 0.000002316
Data Source: BioPlex
AOC3
Tchem
Family: Enzyme
Novelty: 0.00078739
p_int: 0.944216636
p_ni: 0.052400512
p_wrong: 0.003382852
Score: 0.215
Data Source: BioPlex,STRINGDB
ECEL1
Tbio
Family: Enzyme
Novelty: 0.01488521
p_int: 0.943926847
p_ni: 0.056023816
p_wrong: 0.000049337
Data Source: BioPlex
OLFML2B
Tbio
Novelty: 0.19222155
p_int: 0.94224075
p_ni: 0.057253617
p_wrong: 0.000505632
Data Source: BioPlex
CSN1S1
Tbio
Family: Enzyme
Novelty: 0.00200522
p_int: 0.938707298
p_ni: 0.061292658
p_wrong: 4.4e-8
Score: 0.183
Data Source: BioPlex,STRINGDB
CBWD1
Tbio
Novelty: 0.04321511
p_int: 0.937155076
p_ni: 0.062844913
p_wrong: 1.1e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  551.46

PubMed score by year
PubTator Score  268.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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