Tbio ST13 Hsc70-interacting protein

Protein Summary

Description

One HIP oligomer binds the ATPase domains of at least two HSC70 molecules dependent on activation of the HSC70 ATPase by HSP40. Stabilizes the ADP state of HSC70 that has a high affinity for substrate protein. Through its own chaperone activity, it may contribute to the interaction of HSC70 with various target proteins (By similarity). The protein encoded by this gene is an adaptor protein that mediates the association of the heat shock proteins HSP70 and HSP90. This protein has been shown to be involved in the assembly process of glucocorticoid receptor, which requires the assistance of multiple molecular chaperones. The expression of this gene is reported to be downregulated in colorectal carcinoma tissue suggesting that it is a candidate tumor suppressor gene. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jun 2013]

Uniprot Accession IDs

• P50502
• O14999
• Q2TU77
• Hip

Gene Name

• ST13

Ensembl ID

• ENST00000216218
• ENSP00000216218
• ENSG00000100380

Symbol

• AAG2
• FAM10A1
• HIP
• SNC6
• HIP
• HOP
• P48
• AAG2
• SNC6
• HSPABP
• FAM10A1
• FAM10A4
• HSPABP1
• PRO0786

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
kinase perturbation	1
virus perturbation	0.99
molecular function	0.88
protein domain	0.85

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.83   (req: < 5)

Gene RIFs: 15   (req: <= 3)

Antibodies: 339   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 96.83   (req: >= 5)

Gene RIFs: 15   (req: > 3)

Antibodies: 339   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0