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Tbio
PDLIM4
PDZ and LIM domain protein 4

Protein Summary
Description
Isoform 1: Suppresses SRC activation by recognizing and binding to active SRC and facilitating PTPN13-mediated dephosphorylation of SRC 'Tyr-419' leading to its inactivation. Inactivated SRC dissociates from this protein allowing the initiation of a new SRC inactivation cycle (PubMed:19307596). Involved in reorganization of the actin cytoskeleton (PubMed:21636573). In nonmuscle cells, binds to ACTN1 (alpha-actinin-1), increases the affinity of ACTN1 to F-actin (filamentous actin), and promotes formation of actin stress fibers. Involved in regulation of the synaptic AMPA receptor transport in dendritic spines of hippocampal pyramidal neurons directing the receptors toward an insertion at the postsynaptic membrane. Links endosomal surface-internalized GRIA1-containing AMPA receptors to the alpha-actinin/actin cytoskeleton. Increases AMPA receptor-mediated excitatory postsynaptic currents in neurons (By similarity). Isoform 2: Involved in reorganization of the actin cytoskeleton and in re ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000253754
  • ENSP00000253754
  • ENSG00000131435
  • ENST00000379018
  • ENSP00000368303

Symbol
  • RIL
  • RIL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.91
PubMedID
0.76
gene perturbation
0.69
kinase perturbation
0.66
disease perturbation
0.62


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.23   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 186   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 64.23   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 186   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
80.1
red blood cell distribution width
1
1
1
21.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
80.1
red blood cell distribution width
1
21.6
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
PDZ and LIM domain 4
VGNC:4126
462048
Macaque
PDZ and LIM domain 4
707372
Mouse
MGI:1353470
30794
Rat
RGD:3575
24915
Dog
PDZ and LIM domain 4
VGNC:44386
481498
Species
Name
OMA
EggNOG
Inparanoid
Chimp
PDZ and LIM domain 4
Macaque
PDZ and LIM domain 4
Mouse
Rat
Dog
PDZ and LIM domain 4
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P50479-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Protein-Protein Interactions (58)
1 – 10 of 58
KIR3DL2
Tbio
Novelty: 0.00321353
p_int: 0.999977533
p_ni: 1.3e-8
p_wrong: 0.000022454
Score: 0.277
Data Source: BioPlex,STRINGDB
RAC3
Tbio
Family: Enzyme
Novelty: 0.02125361
Score: 0.919
Data Source: STRINGDB
MYO3A
Tbio
Family: Kinase
Novelty: 0.0364819
Score: 0.915
Data Source: STRINGDB
MYO1C
Tbio
Novelty: 0.00967011
Score: 0.915
Data Source: STRINGDB
MYO6
Tbio
Novelty: 0.01073438
Score: 0.914
Data Source: STRINGDB
MYO1A
Tbio
Novelty: 0.00942771
Score: 0.912
Data Source: STRINGDB
CD2AP
Tbio
Novelty: 0.00603034
Score: 0.9
Data Source: STRINGDB
DPYSL3
Tbio
Family: Enzyme
Novelty: 0.01284077
Score: 0.742
Data Source: STRINGDB
ESPN
Tbio
Novelty: 0.0035928
Score: 0.732
Data Source: STRINGDB
CARMIL1
Tbio
Novelty: 0.04162135
Score: 0.72
Data Source: STRINGDB
Publication Statistics
PubMed Score  64.23

PubMed score by year
PubTator Score  24.06

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer