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Tbio
LHX2
LIM/homeobox protein Lhx2

Protein Summary
Description
Acts as a transcriptional activator. Stimulates the promoter of the alpha-glycoprotein gene. Transcriptional regulatory protein involved in the control of cell differentiation in developing lymphoid and neural cell types (By similarity). This gene encodes a protein belonging to a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein may function as a transcriptional regulator. The protein can recapitulate or rescue phenotypes in Drosophila caused by a related protein, suggesting conservation of function during evolution. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000373615
  • ENSP00000362717
  • ENSG00000106689

Symbol
  • LH2
  • LH2
  • hLhx2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.91
PubMedID
0.86
biological process
0.74
transcription factor binding site profile
0.7
transcription factor perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.51   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 295   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 122.51   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 295   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
1
5
0
1.1
80.4
mathematical ability
2
2
2
75.2
monocyte percentage of leukocytes
2
2
2
63.7
hair colour measurement
1
1
1
40.5
waist circumference
1
1
1
35.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hair color
0
1.1
80.4
mathematical ability
2
75.2
monocyte percentage of leukocytes
2
63.7
hair colour measurement
1
40.5
waist circumference
1
35.3
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
LIM homeobox 2
VGNC:4778
473057
Macaque
LIM homeobox 2
694945
Mouse
MGI:96785
16870
Rat
RGD:71076
296706
Dog
LIM homeobox 2
VGNC:42663
491340
Species
Name
OMA
EggNOG
Inparanoid
Chimp
LIM homeobox 2
Macaque
LIM homeobox 2
Mouse
Rat
Dog
LIM homeobox 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P50458-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (12)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
Regulation of expression of SLITs and ROBOs
Reactome
Signaling by ROBO receptors
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
Regulation of expression of SLITs and ROBOs
Signaling by ROBO receptors
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (136)
1 – 10 of 136
SLIT1
Tbio
Novelty: 0.01255624
Score: 0.938
Data Source: STRINGDB
ROBO2
Tbio
Novelty: 0.00757203
Score: 0.931
Data Source: STRINGDB
HOXA2
Tbio
Family: TF
Novelty: 0.00843414
Score: 0.928
Data Source: STRINGDB
ROBO1
Tbio
Novelty: 0.00494884
Score: 0.922
Data Source: STRINGDB
SLIT2
Tbio
Novelty: 0.00710401
Score: 0.919
Data Source: STRINGDB
MSI1
Tbio
Novelty: 0.00670282
Score: 0.906
Data Source: STRINGDB
LHX9
Tbio
Family: TF
Novelty: 0.02952374
Score: 0.904
Data Source: STRINGDB
LDB1
Tbio
Novelty: 0.01110112
Score: 0.841
Data Source: STRINGDB
SIX3
Tbio
Family: TF
Novelty: 0.00599946
Score: 0.798
Data Source: STRINGDB
SIX6
Tbio
Family: TF
Novelty: 0.01261784
Score: 0.762
Data Source: STRINGDB
Publication Statistics
PubMed Score  122.51

PubMed score by year
PubTator Score  129.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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