Protein Summary
Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
- ENST00000358171
- ENSP00000350894
- ENSG00000149257
- ENST00000524558
- ENSP00000434412
- ENST00000533603
- ENSP00000434657
- CBP1
- CBP2
- HSP47
- SERPINH2
- CBP1
- CBP2
- OI10
- gp46
- AsTP3
- HSP47
- PIG14
- PPROM
- RA-A47
- SERPINH2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
PubMedID | 0.99 | ||
transcription factor perturbation | 0.88 | ||
small molecule perturbation | 0.87 | ||
cellular component | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 967.67 (req: < 5)
Gene RIFs: 56 (req: <= 3)
Antibodies: 491 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 967.67 (req: >= 5)
Gene RIFs: 56 (req: > 3)
Antibodies: 491 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (151)
Nearest Tclin Targets
Pathways (24)
Reactome (10)
WikiPathways (14)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Attenuation phase | ||||
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Collagen biosynthesis and modifying enzymes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Attenuation phase | ||||
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Collagen biosynthesis and modifying enzymes | ||||
Viral Interactions (0)
Gene Ontology Terms (16)
Functions (4)
Components (6)
Processes (6)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (9)
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 9 | 4 | 11 | 92.8 | |||||
BMI-adjusted hip circumference | 3 | 3 | 3 | 77.1 | |||||
BMI-adjusted waist circumference | 3 | 2 | 3 | 76.2 | |||||
parental genotype effect measurement | 1 | 1 | 1 | 73.7 | |||||
birth weight | 1 | 1 | 1 | 73.7 | |||||
Items per page:
1 – 5 of 9
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 11 | 92.8 | |||||
BMI-adjusted hip circumference | 3 | 77.1 | |||||
BMI-adjusted waist circumference | 3 | 76.2 | |||||
parental genotype effect measurement | 1 | 73.7 | |||||
birth weight | 1 | 73.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | serpin family H member 1 | VGNC:10185 | 466899 | |||||
Macaque | serpin family H member 1 | 696171 | ||||||
Mouse | MGI:88283 | 12406 | ||||||
Rat | RGD:69302 | 29345 | ||||||
Dog | serpin family H member 1 | VGNC:46041 | 485187 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | serpin family H member 1 | |||||
Macaque | serpin family H member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | serpin family H member 1 | |||||
Publication Statistics
PubMed Score 967.67
PubMed score by year
PubTator Score 277.56
PubTator score by year
Related Publications
Text Mined References (90)
GeneRif Annotations (56)
Items per page:
0 of 0
PMID | Year | Title |
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