Protein Summary
Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
- ENST00000358171
- ENSP00000350894
- ENSG00000149257
- ENST00000524558
- ENSP00000434412
- ENST00000533603
- ENSP00000434657
- CBP1
- CBP2
- HSP47
- SERPINH2
- CBP1
- CBP2
- OI10
- gp46
- AsTP3
- HSP47
- PIG14
- PPROM
- RA-A47
- SERPINH2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
PubMedID | 0.99 | ||
transcription factor perturbation | 0.88 | ||
small molecule perturbation | 0.87 | ||
cellular component | 0.85 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1053.35 (req: < 5)
Gene RIFs: 88 (req: <= 3)
Antibodies: 491 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1053.35 (req: >= 5)
Gene RIFs: 88 (req: > 3)
Antibodies: 491 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0