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Tbio
SERPINH1
Serpin H1

Protein Summary
Description
Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000358171
  • ENSP00000350894
  • ENSG00000149257
  • ENST00000524558
  • ENSP00000434412
  • ENST00000533603
  • ENSP00000434657

Symbol
  • CBP1
  • CBP2
  • HSP47
  • SERPINH2
  • CBP1
  • CBP2
  • OI10
  • gp46
  • AsTP3
  • HSP47
  • PIG14
  • PPROM
  • RA-A47
  • SERPINH2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
PubMedID
0.99
transcription factor perturbation
0.88
small molecule perturbation
0.87
cellular component
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 955   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 491   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 955   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 491   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
7
3
8
94.8
4
4
4
70
BMI-adjusted hip circumference
1
1
1
19.8
physical activity measurement
2
1
2
18.7
BMI-adjusted waist circumference
2
1
2
18.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
8
94.8
4
70
BMI-adjusted hip circumference
1
19.8
physical activity measurement
2
18.7
BMI-adjusted waist circumference
2
18.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
serpin family H member 1
VGNC:10185
466899
Macaque
serpin family H member 1
696171
Mouse
MGI:88283
12406
Rat
RGD:69302
29345
Dog
serpin family H member 1
VGNC:46041
485187
Species
Name
OMA
EggNOG
Inparanoid
Chimp
serpin family H member 1
Macaque
serpin family H member 1
Mouse
Rat
Dog
serpin family H member 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P50454-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (24)
Attenuation phase (R-HSA-3371568)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Attenuation phase
Reactome
Cellular response to heat stress
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Collagen biosynthesis and modifying enzymes
Name
Explore in Pharos
Explore in Source
Attenuation phase
Cellular response to heat stress
Cellular responses to external stimuli
Cellular responses to stress
Collagen biosynthesis and modifying enzymes
Protein-Protein Interactions (151)
1 – 10 of 151
COL26A1
Tbio
Novelty: 0.07322658
Score: 0.992
Data Source: STRINGDB
COL1A2
Tbio
Novelty: 0.00048334
Score: 0.974
Data Source: STRINGDB
CRTAP
Tbio
Novelty: 0.02380647
Score: 0.974
Data Source: STRINGDB
COL1A1
Tbio
Novelty: 0.00063584
Score: 0.973
Data Source: STRINGDB
P3H1
Tbio
Family: Enzyme
Novelty: 0.02067711
Score: 0.973
Data Source: STRINGDB
COL4A1
Tbio
Novelty: 0.00358049
Score: 0.962
Data Source: STRINGDB
COL6A2
Tbio
Novelty: 0.01275082
Score: 0.959
Data Source: STRINGDB
PPIB
Tchem
Family: Enzyme
Novelty: 0.00309224
Score: 0.959
Data Source: STRINGDB
COL3A1
Tbio
Novelty: 0.00197327
Score: 0.959
Data Source: STRINGDB
COL5A1
Tbio
Novelty: 0.00506815
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score  955.00

PubMed score by year
PubTator Score  277.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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