Protein Classes
Protein Summary
Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. This gene encodes a member of the serpin superfamily of serine proteinase inhibitors. The encoded protein is localized to the endoplasmic reticulum and plays a role in collagen biosynthesis as a collagen-specific molecular chaperone. Autoantibodies to the encoded protein have been found in patients with rheumatoid arthritis. Expression of this gene may be a marker for cancer, and nucleotide polymorphisms in this gene may be associated with preterm birth caused by preterm premature rupture of membranes. Alternatively spliced transcript variants have been observed for this gene, and a pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, May 2011]
- ENST00000358171
- ENSP00000350894
- ENSG00000149257
- ENST00000524558
- ENSP00000434412
- ENST00000533603
- ENSP00000434657
- CBP1
- CBP2
- HSP47
- SERPINH2
- CBP1
- CBP2
- OI10
- gp46
- AsTP3
- HSP47
- PIG14
- PPROM
- RA-A47
- SERPINH2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 1 | ||
PubMedID | 0.99 | ||
transcription factor perturbation | 0.88 | ||
small molecule perturbation | 0.87 | ||
cellular component | 0.85 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 955 (req: < 5)
Gene RIFs: 56 (req: <= 3)
Antibodies: 491 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 955 (req: >= 5)
Gene RIFs: 56 (req: > 3)
Antibodies: 491 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 10
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
body height | 7 | 3 | 8 | 94.8 | |||||
4 | 4 | 4 | 70 | ||||||
BMI-adjusted hip circumference | 1 | 1 | 1 | 19.8 | |||||
physical activity measurement | 2 | 1 | 2 | 18.7 | |||||
BMI-adjusted waist circumference | 2 | 1 | 2 | 18.7 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 8 | 94.8 | |||||
4 | 70 | ||||||
BMI-adjusted hip circumference | 1 | 19.8 | |||||
physical activity measurement | 2 | 18.7 | |||||
BMI-adjusted waist circumference | 2 | 18.7 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | serpin family H member 1 | VGNC:10185 | 466899 | |||||
Macaque | serpin family H member 1 | 696171 | ||||||
Mouse | MGI:88283 | 12406 | ||||||
Rat | RGD:69302 | 29345 | ||||||
Dog | serpin family H member 1 | VGNC:46041 | 485187 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | serpin family H member 1 | |||||
Macaque | serpin family H member 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | serpin family H member 1 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (24)
Reactome (10)
WikiPathways (14)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 10
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Attenuation phase | ||||
Reactome | Cellular response to heat stress | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Collagen biosynthesis and modifying enzymes | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Attenuation phase | ||||
Cellular response to heat stress | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Collagen biosynthesis and modifying enzymes | ||||
Gene Ontology Terms (16)
Functions (4)
Components (6)
Processes (6)
Items per page:
10
1 – 4 of 4
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Protein-Protein Interactions (151)
1 – 10 of 151
COL26A1
Novelty: 0.07322658
Score: 0.992
Data Source: STRINGDB
COL1A2
Novelty: 0.00048334
Score: 0.974
Data Source: STRINGDB
CRTAP
Novelty: 0.02380647
Score: 0.974
Data Source: STRINGDB
COL1A1
Novelty: 0.00063584
Score: 0.973
Data Source: STRINGDB
P3H1
Family: Enzyme
Novelty: 0.02067711
Score: 0.973
Data Source: STRINGDB
COL4A1
Novelty: 0.00358049
Score: 0.962
Data Source: STRINGDB
COL6A2
Novelty: 0.01275082
Score: 0.959
Data Source: STRINGDB
PPIB
Family: Enzyme
Novelty: 0.00309224
Score: 0.959
Data Source: STRINGDB
COL3A1
Novelty: 0.00197327
Score: 0.959
Data Source: STRINGDB
COL5A1
Novelty: 0.00506815
Score: 0.952
Data Source: STRINGDB
Publication Statistics
PubMed Score 955.00
PubMed score by year
PubTator Score 277.56
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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GWAS Trait