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Tbio
SLC26A2
Sulfate transporter

Protein Summary
Description
Sulfate transporter. May play a role in endochondral bone formation. The diastrophic dysplasia sulfate transporter is a transmembrane glycoprotein implicated in the pathogenesis of several human chondrodysplasias. It apparently is critical in cartilage for sulfation of proteoglycans and matrix organization. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000286298
  • ENSP00000286298
  • ENSG00000155850

Symbol
  • DTD
  • DTDST
  • DTD
  • EDM4
  • DTDST
  • MST153
  • D5S1708
  • MSTP157
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
pathway
0.99
histone modification site profile
0.91
gene perturbation
0.9
small molecule perturbation
0.86
protein domain
0.85


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 303.25   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 106   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 303.25   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 106   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (69)
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.999937715
p_ni:  0.000062285
Data Source:  BioPlex
TMEM52B
Tdark
Novelty:  1.55824039
p_int:  0.990246144
p_ni:  0.009753855
p_wrong:  1e-9
Data Source:  BioPlex
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.987600906
p_ni:  0.012285591
p_wrong:  0.000113503
Data Source:  BioPlex
ERGIC3
Tbio
Novelty:  0.11095443
p_int:  0.979098997
p_ni:  0.020753789
p_wrong:  0.000147214
Score:  0.164
Data Source:  BioPlex,STRINGDB
VAPB
Tbio
Novelty:  0.00542377
p_int:  0.978740742
p_ni:  0.021259257
p_wrong:  1e-9
Data Source:  BioPlex
PMEL
Tbio
Novelty:  0.00116525
p_int:  0.958409234
p_ni:  0.039944876
p_wrong:  0.00164589
Data Source:  BioPlex
SLC22A2
Tchem
Family:  Transporter
Novelty:  0.00439263
p_int:  0.947960148
p_ni:  0.052015717
p_wrong:  0.000024135
Data Source:  BioPlex
CTLA4
Tclin
Novelty:  0.00012781
p_int:  0.946916506
p_ni:  0.053019166
p_wrong:  0.000064328
Data Source:  BioPlex
LRRC55
Tbio
Family:  IC
Novelty:  0.25121277
p_int:  0.932550965
p_ni:  0.067381
p_wrong:  0.000068034
Data Source:  BioPlex
TNFRSF10C
Tbio
Novelty:  0.0088942
p_int:  0.903589765
p_ni:  0.096392725
p_wrong:  0.00001751
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (68)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Defective SLC26A2 causes chondrodysplasias
Reactome
Disease
Reactome
Diseases associated with glycosaminoglycan metabolism
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Defective SLC26A2 causes chondrodysplasias
Disease
Diseases associated with glycosaminoglycan metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (18)
Find Similar Targets
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Disease Associations (null)
No disease associations found
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
2
6
6
98.8
monocyte count
1
2
2
87.1
granulocyte percentage of myeloid white cells
1
2
2
85.2
neutrophil percentage of leukocytes
1
1
1
68.8
mean reticulocyte volume
1
1
1
49.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte percentage of leukocytes
6
98.8
monocyte count
2
87.1
granulocyte percentage of myeloid white cells
2
85.2
neutrophil percentage of leukocytes
1
68.8
mean reticulocyte volume
1
49.5
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 26 member 2
709998
Mouse
MGI:892977
13521
Rat
RGD:620622
117267
Dog
solute carrier family 26 member 2
VGNC:46322
612273
Horse
solute carrier family 26 member 2
100034141
Species
Name
OMA
EggNOG
Inparanoid
Macaque
solute carrier family 26 member 2
Mouse
Rat
Dog
solute carrier family 26 member 2
Horse
solute carrier family 26 member 2
Publication Statistics
PubMed Score 303.25
PubMed score by year
PubTator Score 140.16
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title