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Tbio
GATM
Glycine amidinotransferase, mitochondrial

Protein Summary
Description
Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine. Creatine plays a vital role in energy metabolism in muscle tissues. May play a role in embryonic and central nervous system development. May be involved in the response to heart failure by elevating local creatine synthesis. This gene encodes a mitochondrial enzyme that belongs to the amidinotransferase family. This enzyme is involved in creatine biosynthesis, whereby it catalyzes the transfer of a guanido group from L-arginine to glycine, resulting in guanidinoacetic acid, the immediate precursor of creatine. Mutations in this gene cause arginine:glycine amidinotransferase deficiency, an inborn error of creatine synthesis characterized by cognitive disability, language impairment, and behavioral disorders. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000396659
  • ENSP00000379895
  • ENSG00000171766
  • ENST00000558336
  • ENSP00000454008

Symbol
  • AGAT
  • AT
  • AGAT
  • CCDS3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
PubMedID
0.9
transcription factor perturbation
0.74
small molecule perturbation
0.73
virus perturbation
0.72


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.75   (req: < 5)
Gene RIFs: 11   (req: <= 3)
Antibodies: 302   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 295.75   (req: >= 5)
Gene RIFs: 11   (req: > 3)
Antibodies: 302   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
2
3
95.8
urinary potassium to creatinine ratio
1
1
1
69.9
urinary albumin to creatinine ratio
2
2
2
68.3
serum metabolite measurement
1
1
1
64.6
1
1
0
1.1
58.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
glomerular filtration rate
3
95.8
urinary potassium to creatinine ratio
1
69.9
urinary albumin to creatinine ratio
2
68.3
serum metabolite measurement
1
64.6
0
1.1
58.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycine amidinotransferase
VGNC:6601
453401
Macaque
glycine amidinotransferase
713306
Mouse
MGI:1914342
67092
Rat
RGD:71090
81660
Dog
glycine amidinotransferase
VGNC:41129
414733
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycine amidinotransferase
Macaque
glycine amidinotransferase
Mouse
Rat
Dog
glycine amidinotransferase
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (12)
Creatine metabolism (R-HSA-71288)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Creatine metabolism
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Creatine metabolism
Metabolism
Metabolism of amino acids and derivatives
Gene Ontology Terms (12)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (91)
1 – 10 of 91
PDE4DIP
Tbio
Novelty: 0.03414104
p_int: 0.99688834
p_ni: 0.003111658
p_wrong: 2e-9
Score: 0.239
Data Source: BioPlex,STRINGDB
GAMT
Tbio
Family: Enzyme
Novelty: 0.00656642
Score: 0.988
Data Source: STRINGDB
AZIN2
Tbio
Family: Enzyme
Novelty: 0.00750311
Score: 0.968
Data Source: STRINGDB
ARG2
Tchem
Family: Enzyme
Novelty: 0.0006655
Score: 0.962
Data Source: STRINGDB
ARG1
Tchem
Family: Enzyme
Novelty: 0.00063728
Score: 0.948
Data Source: STRINGDB
AGXT2
Tbio
Family: Enzyme
Novelty: 0.02018289
Score: 0.938
Data Source: STRINGDB
ALDH3A2
Tbio
Family: Enzyme
Novelty: 0.0059198
Score: 0.927
Data Source: STRINGDB
SHMT1
Tbio
Family: Enzyme
Novelty: 0.00200739
Score: 0.926
Data Source: STRINGDB
SHMT2
Tbio
Family: Enzyme
Novelty: 0.00234505
Score: 0.926
Data Source: STRINGDB
AGXT
Tbio
Family: Enzyme
Novelty: 0.00267512
Score: 0.926
Data Source: STRINGDB
Publication Statistics
PubMed Score  295.75

PubMed score by year
PubTator Score  147.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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