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Tchem
CPT1A
Carnitine O-palmitoyltransferase 1, liver isoform

Protein Summary
Description
Catalyzes the transfer of the acyl group of long-chain fatty acid-CoA conjugates onto carnitine, an essential step for the mitochondrial uptake of long-chain fatty acids and their subsequent beta-oxidation in the mitochondrion. Plays an important role in triglyceride metabolism. The mitochondrial oxidation of long-chain fatty acids is initiated by the sequential action of carnitine palmitoyltransferase I (which is located in the outer membrane and is detergent-labile) and carnitine palmitoyltransferase II (which is located in the inner membrane and is detergent-stable), together with a carnitine-acylcarnitine translocase. CPT I is the key enzyme in the carnitine-dependent transport across the mitochondrial inner membrane and its deficiency results in a decreased rate of fatty acid beta-oxidation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000265641
  • ENSP00000265641
  • ENSG00000110090
  • ENST00000376618
  • ENSP00000365803
  • ENST00000539743
  • ENSP00000446108
  • ENST00000540367
  • ENSP00000439084

Symbol
  • CPT1
  • CPT1
  • CPT1-L
  • L-CPT1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
interacting protein
0.99
biological process
0.95
disease perturbation
0.93
PubMedID
0.86


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 464.6   (req: < 5)
Gene RIFs: 68   (req: <= 3)
Antibodies: 397   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 464.6   (req: >= 5)
Gene RIFs: 68   (req: > 3)
Antibodies: 397   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 467
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0