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Tchem
HTR6
5-hydroxytryptamine receptor 6

Protein Summary
Description
This is one of the several different receptors for 5-hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that stimulate adenylate cyclase. It has a high affinity for tricyclic psychotropic drugs (By similarity). Controls pyramidal neurons migration during corticogenesis, through the regulation of CDK5 activity (By similarity). Is an activator of TOR signaling (PubMed:23027611). This gene encodes a protein that belongs to the seven-transmembrane G protein-coupled receptor family of proteins. The encoded protein couples with the Gs alpha subunit and stimulates adenylate cyclase to activate the cyclic AMP-dependent signaling pathway. This receptor is thought to regulate cholinergic neuronal transmission in the brain. Several antidepressants and antipsychotic drugs have a high affinity for this receptor. [provided by RefSeq, Aug 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000289753
  • ENSP00000289753
  • ENSG00000158748

Symbol
  • 5-HT6
  • 5-HT6R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
ligand (chemical)
1
drug
0.81
biological process
0.78
phenotype
0.58
disease
0.54


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.68   (req: < 5)
Gene RIFs: 35   (req: <= 3)
Antibodies: 99   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.68   (req: >= 5)
Gene RIFs: 35   (req: > 3)
Antibodies: 99   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1964
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 35
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
1
1
0
1
56.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
chronotype measurement
0
1
56.6
Pathways (27)
Amine ligand-binding receptors (R-HSA-375280)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amine ligand-binding receptors
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (s) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Name
Explore in Pharos
Explore in Source
Amine ligand-binding receptors
Class A/1 (Rhodopsin-like receptors)
G alpha (s) signalling events
GPCR downstream signalling
GPCR ligand binding
Gene Ontology Terms (13)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (131)
1 – 10 of 131
ADCY3
Tbio
Family: Enzyme
Novelty: 0.00260265
Score: 0.94
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.939
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.939
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.939
Data Source: STRINGDB
GNAS
Tbio
Novelty: 0.00284739
Score: 0.939
Data Source: STRINGDB
HTR4
Tclin
Family: GPCR
Novelty: 0.00951779
Score: 0.923
Data Source: STRINGDB
ADCY7
Tbio
Family: Enzyme
Novelty: 0.00984562
Score: 0.922
Data Source: STRINGDB
ADCY4
Tbio
Family: Enzyme
Novelty: 0.00465974
Score: 0.922
Data Source: STRINGDB
GIPR
Tchem
Family: GPCR
Novelty: 0.00961809
Score: 0.92
Data Source: STRINGDB
HTR7
Tclin
Family: GPCR
Novelty: 0.00169884
Score: 0.919
Data Source: STRINGDB
Publication Statistics
PubMed Score  84.68

PubMed score by year
PubTator Score  89.78

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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