Protein Classes
Protein Summary
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C. Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in ...more
- ENST00000369842
- ENSP00000358857
- ENSG00000102119
- EDMD
- STA
- STA
- EDMD
- LEMD5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.99 | ||
cellular component | 0.94 | ||
disease perturbation | 0.93 | ||
hub protein | 0.88 | ||
ligand (protein) perturbation | 0.83 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 740.42 (req: < 5)
Gene RIFs: 61 (req: <= 3)
Antibodies: 409 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 740.42 (req: >= 5)
Gene RIFs: 61 (req: > 3)
Antibodies: 409 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
GWAS Traits (1)
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 1 | 1 | 2.9 | |||||
Items per page:
1 – 1 of 1
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular volume | 1 | 2.9 | |||||
Orthologs (7)
Protein Structure (4 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 4 of 4
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (17)
Reactome (12)
KEGG (3)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 12
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Depolymerisation of the Nuclear Lamina | ||||
Reactome | Initiation of Nuclear Envelope Reformation | ||||
Reactome | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Depolymerisation of the Nuclear Lamina | ||||
Initiation of Nuclear Envelope Reformation | ||||
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | ||||
Gene Ontology Terms (23)
Functions (3)
Components (11)
Processes (9)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Protein-Protein Interactions (116)
1 – 10 of 116
BANF1
Novelty: 0.00092814
Score: 0.998
Data Source: Reactome,STRINGDB
LMNB1
Novelty: 0.00127348
Score: 0.988
Data Source: STRINGDB
LEMD3
Novelty: 0.00579701
Score: 0.987
Data Source: STRINGDB
LEMD2
Novelty: 0.12460123
Score: 0.964
Data Source: STRINGDB
LMNA
Novelty: 0.00046972
Score: 0.952
Data Source: Reactome,STRINGDB
ANKLE2
Novelty: 0.0995907
Score: 0.951
Data Source: STRINGDB
VRK1
Family: Kinase
Novelty: 0.00761136
Score: 0.944
Data Source: Reactome,STRINGDB
SYNE2
Novelty: 0.01368736
Score: 0.94
Data Source: STRINGDB
PRKCA
Family: Kinase
Novelty: 0.00057611
Score: 0.907
Data Source: Reactome,STRINGDB
PRKCB
Family: Kinase
Novelty: 0.00189802
Score: 0.9
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score 740.42
PubMed score by year
PubTator Score 304.54
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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