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Tbio
EMD
Emerin

Protein Summary
Description
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C. Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369842
  • ENSP00000358857
  • ENSG00000102119

Symbol
  • EDMD
  • STA
  • STA
  • EDMD
  • LEMD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
cellular component
0.94
disease perturbation
0.93
hub protein
0.88
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 750.31   (req: < 5)
Gene RIFs: 61   (req: <= 3)
Antibodies: 409   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 750.31   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (116)
BANF1
Tbio
Novelty:  0.00092814
Score:  0.998
Data Source:  Reactome,STRINGDB
LMNB1
Tbio
Novelty:  0.00127348
Score:  0.988
Data Source:  STRINGDB
LEMD3
Tbio
Novelty:  0.00579701
Score:  0.987
Data Source:  STRINGDB
LEMD2
Tbio
Novelty:  0.12460123
Score:  0.964
Data Source:  STRINGDB
LMNA
Tbio
Novelty:  0.00046972
Score:  0.952
Data Source:  Reactome,STRINGDB
ANKLE2
Tbio
Novelty:  0.0995907
Score:  0.951
Data Source:  STRINGDB
VRK1
Tbio
Family:  Kinase
Novelty:  0.00761136
Score:  0.944
Data Source:  Reactome,STRINGDB
SYNE2
Tbio
Novelty:  0.01368736
Score:  0.94
Data Source:  STRINGDB
PRKCA
Tchem
Family:  Kinase
Novelty:  0.00057611
Score:  0.907
Data Source:  Reactome,STRINGDB
PRKCB
Tchem
Family:  Kinase
Novelty:  0.00189802
Score:  0.9
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (17)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Depolymerisation of the Nuclear Lamina
Reactome
Initiation of Nuclear Envelope Reformation
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Depolymerisation of the Nuclear Lamina
Initiation of Nuclear Envelope Reformation
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
3
3
91.4
reticulocyte count
2
2
2
89.6
leukocyte count
1
1
1
72.5
sex hormone-binding globulin measurement
3
2
3
57.7
bilirubin measurement
1
1
1
26.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte measurement
3
91.4
reticulocyte count
2
89.6
leukocyte count
1
72.5
sex hormone-binding globulin measurement
3
57.7
bilirubin measurement
1
26.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
emerin
699400
Mouse
MGI:108117
13726
Rat
RGD:2551
25437
Dog
emerin
VGNC:40340
492249
Horse
emerin
VGNC:17559
100059369
Species
Name
OMA
EggNOG
Inparanoid
Macaque
emerin
Mouse
Rat
Dog
emerin
Horse
emerin
Publication Statistics
PubMed Score 750.31
PubMed score by year
PubTator Score 304.54
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title