Pharos : Target Details

Tbio

Protein Classes

Protein Summary

Description

Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C. Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in ...more

Uniprot Accession IDs

Gene Name

Ensembl ID

ENST00000369842
ENSP00000358857
ENSG00000102119

Symbol

EDMD
STA
STA
EDMD
LEMD5

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
interacting protein	0.99

cellular component	0.94

disease perturbation	0.93

hub protein	0.88

ligand (protein) perturbation	0.83

IDG Partner Tools

GlyGen

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 740.42 (req: < 5)

View Publications

Gene RIFs: 61 (req: <= 3)

View Gene RIFs

Antibodies: 409 (req: <= 50)

View Antibodies

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 740.42 (req: >= 5)

Gene RIFs: 61 (req: > 3)

Antibodies: 409 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (1)

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	1	1	1		2.9

Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

1 – 1 of 1

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
mean corpuscular volume	EFO_0004526	1		2.9

Beta Count

Odds Ratio

Protein Data Bank (4)

1 – 4 of 4

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (17)

Reactome (12)

KEGG (3)

WikiPathways (2)

Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:

1 – 5 of 12

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170

Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278

Reactome	Depolymerisation of the Nuclear Lamina	16 targets	R-HSA-4419969

Reactome	Initiation of Nuclear Envelope Reformation	14 targets	R-HSA-2995383

Reactome	Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	23 targets	R-HSA-9609523

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170

Cell Cycle, Mitotic	495 targets	R-HSA-69278

Depolymerisation of the Nuclear Lamina	16 targets	R-HSA-4419969

Initiation of Nuclear Envelope Reformation	14 targets	R-HSA-2995383

Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	23 targets	R-HSA-9609523

Gene Ontology Terms (23)

Functions (3)

Components (11)

Processes (9)

Items per page:

1 – 3 of 3

GO Term	Evidence	Assigned by
actin binding	Inferred from Direct Assay (IDA)	UniProtKB

beta-tubulin binding	Inferred from Direct Assay (IDA)	UniProtKB

cadherin binding	Inferred from High Throughput Direct Assay (HDA)	BHF-UCL

Protein-Protein Interactions (116)

1 – 10 of 116

See Interactions on String-DB

BANF1

Tbio

Novelty: 0.00092814

Score: 0.998

Data Source: Reactome,STRINGDB

LMNB1

Tbio

Novelty: 0.00127348

Score: 0.988

Data Source: STRINGDB

LEMD3

Tbio

Novelty: 0.00579701

Score: 0.987

Data Source: STRINGDB

LEMD2

Tbio

Novelty: 0.12460123

Score: 0.964

Data Source: STRINGDB

LMNA

Tbio

Novelty: 0.00046972

Score: 0.952

Data Source: Reactome,STRINGDB

ANKLE2

Tbio

Novelty: 0.0995907

Score: 0.951

Data Source: STRINGDB

VRK1

Tbio

Family: Kinase

Novelty: 0.00761136

Score: 0.944

Data Source: Reactome,STRINGDB

SYNE2

Tbio

Novelty: 0.01368736

Score: 0.94

Data Source: STRINGDB

PRKCA

Tchem

Family: Kinase

Novelty: 0.00057611

Score: 0.907

Data Source: Reactome,STRINGDB

PRKCB

Tchem

Family: Kinase

Novelty: 0.00189802

Score: 0.9

Data Source: Reactome,STRINGDB

Publication Statistics

PubMed Score 740.42

PubMed score by year

PubTator Score 304.54

PubTator score by year

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword


3D-structure

Acetylation

Actin-binding

Cardiomyopathy

Complete proteome

Direct protein sequencing

Disease mutation

Emery-Dreifuss muscular dystrophy

Membrane

Microtubule

GWAS Trait


mean corpuscular volume

MGI Phenotype


behavior/neurological phenotype

cardiovascular system phenotype

homeostasis/metabolism phenotype

muscle phenotype