Protein Summary
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C. Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in ...more
- ENST00000369842
- ENSP00000358857
- ENSG00000102119
- EDMD
- STA
- STA
- EDMD
- LEMD5
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
interacting protein | 0.99 | ||
cellular component | 0.94 | ||
disease perturbation | 0.93 | ||
hub protein | 0.88 | ||
ligand (protein) perturbation | 0.83 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 750.31 (req: < 5)
Gene RIFs: 61 (req: <= 3)
Antibodies: 409 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 750.31 (req: >= 5)
Gene RIFs: 61 (req: > 3)
Antibodies: 409 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (116)
Nearest Tclin Targets
Pathways (17)
Reactome (12)
KEGG (3)
WikiPathways (2)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell Cycle | ||||
Reactome | Cell Cycle, Mitotic | ||||
Reactome | Depolymerisation of the Nuclear Lamina | ||||
Reactome | Initiation of Nuclear Envelope Reformation | ||||
Reactome | Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell Cycle | ||||
Cell Cycle, Mitotic | ||||
Depolymerisation of the Nuclear Lamina | ||||
Initiation of Nuclear Envelope Reformation | ||||
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane | ||||
Viral Interactions (0)
Gene Ontology Terms (23)
Functions (3)
Components (11)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from High Throughput Direct Assay (HDA) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (8)
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 3 | 3 | 91.4 | |||||
reticulocyte count | 2 | 2 | 2 | 89.6 | |||||
leukocyte count | 1 | 1 | 1 | 72.5 | |||||
sex hormone-binding globulin measurement | 3 | 2 | 3 | 57.7 | |||||
bilirubin measurement | 1 | 1 | 1 | 26.1 | |||||
Items per page:
1 – 5 of 8
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
reticulocyte measurement | 3 | 91.4 | |||||
reticulocyte count | 2 | 89.6 | |||||
leukocyte count | 1 | 72.5 | |||||
sex hormone-binding globulin measurement | 3 | 57.7 | |||||
bilirubin measurement | 1 | 26.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | emerin | 699400 | ||||||
Mouse | MGI:108117 | 13726 | ||||||
Rat | RGD:2551 | 25437 | ||||||
Dog | emerin | VGNC:40340 | 492249 | |||||
Horse | emerin | VGNC:17559 | 100059369 | |||||
Publication Statistics
PubMed Score 750.31
PubMed score by year
PubTator Score 304.54
PubTator score by year
Related Publications
Text Mined References (109)
GeneRif Annotations (61)
Items per page:
0 of 0
PMID | Year | Title |
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