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Tbio
EMD
Emerin

Protein Summary
Description
Stabilizes and promotes the formation of a nuclear actin cortical network. Stimulates actin polymerization in vitro by binding and stabilizing the pointed end of growing filaments. Inhibits beta-catenin activity by preventing its accumulation in the nucleus. Acts by influencing the nuclear accumulation of beta-catenin through a CRM1-dependent export pathway. Links centrosomes to the nuclear envelope via a microtubule association. EMD and BAF are cooperative cofactors of HIV-1 infection. Association of EMD with the viral DNA requires the presence of BAF and viral integrase. The association of viral DNA with chromatin requires the presence of BAF and EMD. Required for proper localization of non-farnesylated prelamin-A/C. Emerin is a serine-rich nuclear membrane protein and a member of the nuclear lamina-associated protein family. It mediates membrane anchorage to the cytoskeleton. Dreifuss-Emery muscular dystrophy is an X-linked inherited degenerative myopathy resulting from mutation in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000369842
  • ENSP00000358857
  • ENSG00000102119

Symbol
  • EDMD
  • STA
  • STA
  • EDMD
  • LEMD5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
cellular component
0.94
disease perturbation
0.93
hub protein
0.88
ligand (protein) perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 599.13   (req: < 5)
View Publications
Gene RIFs: 61   (req: <= 3)
View Gene RIFs
Antibodies: 409   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 599.13   (req: >= 5)
Gene RIFs: 61   (req: > 3)
Antibodies: 409   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (4)
1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (17)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
597 targets
R-HSA-1640170
Reactome
Cell Cycle, Mitotic
495 targets
R-HSA-69278
Reactome
Depolymerisation of the Nuclear Lamina
16 targets
R-HSA-4419969
Reactome
Initiation of Nuclear Envelope Reformation
14 targets
R-HSA-2995383
Reactome
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
23 targets
R-HSA-9609523
Name
Explore in Pharos
Explore in Source
Cell Cycle
597 targets
R-HSA-1640170
Cell Cycle, Mitotic
495 targets
R-HSA-69278
Depolymerisation of the Nuclear Lamina
16 targets
R-HSA-4419969
Initiation of Nuclear Envelope Reformation
14 targets
R-HSA-2995383
Insertion of tail-anchored proteins into the endoplasmic reticulum membrane
23 targets
R-HSA-9609523
Gene Ontology Terms (23)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
actin binding
Inferred from Direct Assay (IDA)
UniProtKB
beta-tubulin binding
Inferred from Direct Assay (IDA)
UniProtKB
cadherin binding
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Protein-Protein Interactions (116)
1 – 10 of 116
BANF1
Tbio
Novelty: 0.0011638
Score: 0.998
Data Source: Reactome,STRINGDB
LMNB1
Tbio
Novelty: 0.00131872
Score: 0.988
Data Source: STRINGDB
LEMD3
Tbio
Novelty: 0.00728793
Score: 0.987
Data Source: STRINGDB
LEMD2
Tdark
Novelty: 0.1754386
Score: 0.964
Data Source: STRINGDB
LMNA
Tbio
Novelty: 0.00051948
Score: 0.952
Data Source: Reactome,STRINGDB
ANKLE2
Tbio
Novelty: 0.07048215
Score: 0.951
Data Source: STRINGDB
VRK1
Tbio
Family: Kinase
Novelty: 0.00868069
Score: 0.944
Data Source: Reactome,STRINGDB
SYNE2
Tbio
Novelty: 0.00193453
Score: 0.94
Data Source: STRINGDB
PRKCA
Tchem
Family: Kinase
Novelty: 0.00099987
Score: 0.907
Data Source: Reactome,STRINGDB
PRKCB
Tchem
Family: Kinase
Novelty: 0.0023066
Score: 0.9
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  599.13

PubMed score by year
PubTator Score  304.54

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer