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Tbio
GDI2
Rab GDP dissociation inhibitor beta

Protein Summary
Description
Regulates the GDP/GTP exchange reaction of most Rab proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. GDP dissociation inhibitors are proteins that regulate the GDP-GTP exchange reaction of members of the rab family, small GTP-binding proteins of the ras superfamily, that are involved in vesicular trafficking of molecules between cellular organelles. GDIs slow the rate of dissociation of GDP from rab proteins and release GDP from membrane-bound rabs. GDI2 is ubiquitously expressed. The GDI2 gene contains many repetitive elements indicating that it may be prone to inversion/deletion rearrangements. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000380181
  • ENSP00000369528
  • ENSG00000057608
  • ENST00000380191
  • ENSP00000369538

Symbol
  • RABGDIB
  • RABGDIB
  • HEL-S-46e
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
kinase perturbation
0.99
virus perturbation
0.97
disease perturbation
0.96
co-expressed gene
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.06   (req: < 5)
Gene RIFs: 3   (req: <= 3)
Antibodies: 225   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 42.06   (req: >= 5)
Gene RIFs: 3   (req: > 3)
Antibodies: 225   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (288)
RAB43
Tbio
Family:  Enzyme
Novelty:  0.07527576
p_int:  0.999921328
p_ni:  0.000078673
Score:  0.42
Data Source:  BioPlex,STRINGDB
RAB1B
Tbio
Family:  Enzyme
Novelty:  0.02156819
p_int:  0.99979229
p_ni:  0.00020771
Score:  0.997
Data Source:  BioPlex,STRINGDB
RAB9A
Tbio
Family:  Enzyme
Novelty:  0.07006531
p_int:  0.999019754
p_ni:  0.000980246
Score:  0.979
Data Source:  BioPlex,Reactome,STRINGDB
RAB1A
Tbio
Family:  Enzyme
Novelty:  0.00307527
p_int:  0.997803131
p_ni:  0.002196869
Score:  0.997
Data Source:  BioPlex,Reactome,STRINGDB
FN1
Tchem
Novelty:  0.00003647
p_int:  0.994568467
p_ni:  0.005431533
Score:  0.165
Data Source:  BioPlex,STRINGDB
RAB2B
Tbio
Family:  Enzyme
Novelty:  0.18567584
p_int:  0.99369691
p_ni:  0.006303091
Score:  0.346
Data Source:  BioPlex,STRINGDB
C10orf88
Tdark
Novelty:  0.49807003
p_int:  0.980189479
p_ni:  0.019810521
Data Source:  BioPlex
GDI1
Tbio
Novelty:  0.01710945
p_int:  0.977515287
p_ni:  0.022484713
Score:  0.981
Data Source:  BioPlex,STRINGDB
RAB5A
Tbio
Family:  Enzyme
Novelty:  0.00111347
p_int:  0.964363113
p_ni:  0.035636887
Score:  0.99
Data Source:  BioPlex,Reactome,STRINGDB
RAB31
Tbio
Family:  Enzyme
Novelty:  0.03673084
p_int:  0.958567634
p_ni:  0.041432366
Score:  0.972
Data Source:  BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (11)
Immune System (R-HSA-168256)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Membrane Trafficking
Reactome
Neutrophil degranulation
Reactome
RAB GEFs exchange GTP for GDP on RABs
Name
Explore in Pharos
Explore in Source
Immune System
Innate Immune System
Membrane Trafficking
Neutrophil degranulation
RAB GEFs exchange GTP for GDP on RABs
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
2
2
69
blood protein measurement
1
1
1
57.4
age at menopause
1
1
1
29.3
systolic blood pressure
1
1
1
23.7
heel bone mineral density
1
1
1
8.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
2
69
blood protein measurement
1
57.4
age at menopause
1
29.3
systolic blood pressure
1
23.7
heel bone mineral density
1
8.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
GDP dissociation inhibitor 2
VGNC:3865
450283
Macaque
GDP dissociation inhibitor 2
712510
Mouse
MGI:99845
14569
Rat
RGD:61802
29662
Dog
GDP dissociation inhibitor 2
VGNC:41165
403818
Species
Name
OMA
EggNOG
Inparanoid
Chimp
GDP dissociation inhibitor 2
Macaque
GDP dissociation inhibitor 2
Mouse
Rat
Dog
GDP dissociation inhibitor 2
Publication Statistics
PubMed Score 42.06
PubMed score by year
PubTator Score 17.58
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Text