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Tchem
NPY4R
Neuropeptide Y receptor type 4

Protein Summary
Description
Receptor for neuropeptide Y and peptide YY. The rank order of affinity of this receptor for pancreatic polypeptides is PP, PP (2-36) and [Ile-31, Gln-34] PP > [Pro-34] PYY > PYY and [Leu-31, Pro-34] NPY > NPY > PYY (3-36) and NPY (2-36) > PP (13-36) > PP (31-36) > NPY free acid.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374312
  • ENSP00000363431
  • ENSG00000204174
  • ENST00000395716
  • ENSP00000379066
  • ENST00000612632
  • ENSP00000480883

Symbol
  • PPYR1
  • PP1
  • NPY4R
  • PPYR1
  • NPY4-R
  • CH17-360D5.1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.97
ligand (chemical)
0.7
ligand (protein)
0.68
chemical
0.46
cell line
0.43


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.74   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 222   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 24.74   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 222   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 20
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (8)
Class A/1 (Rhodopsin-like receptors) (R-HSA-373076)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Class A/1 (Rhodopsin-like receptors)
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
GPCR ligand binding
Reactome
Peptide ligand-binding receptors
Name
Explore in Pharos
Explore in Source
Class A/1 (Rhodopsin-like receptors)
G alpha (i) signalling events
GPCR downstream signalling
GPCR ligand binding
Peptide ligand-binding receptors
Protein-Protein Interactions (271)
1 – 10 of 271
NPY
Tbio
Novelty: 0.00014761
Score: 0.976
Data Source: Reactome,STRINGDB
PYY
Tbio
Novelty: 0.0007798
Score: 0.971
Data Source: Reactome,STRINGDB
PPY
Tbio
Novelty: 0.00056678
Score: 0.968
Data Source: Reactome,STRINGDB
GAL
Tbio
Novelty: 0.00057698
Score: 0.95
Data Source: STRINGDB
SST
Tbio
Novelty: 0.0000732
Score: 0.946
Data Source: STRINGDB
POMC
Tbio
Novelty: 0.00002654
Score: 0.931
Data Source: STRINGDB
PDYN
Tbio
Novelty: 0.00033852
Score: 0.93
Data Source: STRINGDB
GALR2
Tchem
Family: GPCR
Novelty: 0.008592
Score: 0.926
Data Source: STRINGDB
DRD4
Tchem
Family: GPCR
Novelty: 0.00047256
Score: 0.924
Data Source: STRINGDB
GALR3
Tchem
Family: GPCR
Novelty: 0.0168579
Score: 0.924
Data Source: STRINGDB
Publication Statistics
PubMed Score  24.74

PubMed score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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