PPOX
Protoporphyrinogen oxidase
Protein Summary
Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX. This gene encodes the penultimate enzyme of heme biosynthesis, which catalyzes the 6-electron oxidation of protoporphyrinogen IX to form protoporphyrin IX. Mutations in this gene cause variegate porphyria, an autosomal dominant disorder of heme metabolism resulting from a deficiency in protoporphyrinogen oxidase, an enzyme located on the inner mitochondrial membrane. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008]
- ENST00000352210
- ENSP00000343943
- ENSG00000143224
- ENST00000367999
- ENSP00000356978
- VP
- PPO
- V290M
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor binding site profile | 0.8 | ||
cellular component | 0.79 | ||
transcription factor | 0.7 | ||
histone modification site profile | 0.69 | ||
virus perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 198.01 (req: < 5)
Gene RIFs: 24 (req: <= 3)
Antibodies: 242 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 198.01 (req: >= 5)
Gene RIFs: 24 (req: > 3)
Antibodies: 242 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 22
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0