Tchem MMP14 Matrix metalloproteinase-14

Protein Summary

Description

Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140). Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the protein encoded by this gene is a member of the membrane-type MMP (MT-MMP) subfamily; each member of this subfamily contains a potential transmembrane domain suggesting that these proteins are expressed at the cell surface rather than secreted. This protein activates MMP2 protein, and this activity may be involved in tumor invasion. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P50281
• A8K5L0
• Q6GSF3
• Q92678
• MMP-14

Gene Name

• MMP14

Ensembl ID

• ENST00000311852
• ENSP00000308208
• ENSG00000157227

Symbol

• MMP-14
• MMP-X1
• MT-MMP
• MT1MMP
• MTMMP1
• WNCHRS
• MT1-MMP
• MT-MMP 1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
PubMedID	0.95
biological process	0.94
molecular function	0.9
disease perturbation	0.87

Protein Classes

PANTHER Classes

Protein / ... / Metalloprotease / Matrix Metalloproteinase-14

DTO Classes

Protein / Enzyme / Protease / Metalloprotease / Matrix Metalloproteinase-14

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1389.28   (req: < 5)

Gene RIFs: 514   (req: <= 3)

Antibodies: 974   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1389.28   (req: >= 5)

Gene RIFs: 514   (req: > 3)

Antibodies: 974   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 359

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0