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Tchem
MMP14
Matrix metalloproteinase-14

Protein Summary
Description
Endopeptidase that degrades various components of the extracellular matrix such as collagen. Activates progelatinase A. Essential for pericellular collagenolysis and modeling of skeletal and extraskeletal connective tissues during development (By similarity). May be involved in actin cytoskeleton reorganization by cleaving PTK7 (PubMed:20837484). Acts as a positive regulator of cell growth and migration via activation of MMP15. Involved in the formation of the fibrovascular tissues in association with pro-MMP2 (PubMed:12714657). Cleaves ADGRB1 to release vasculostatin-40 which inhibits angiogenesis (PubMed:22330140). Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000311852
  • ENSP00000308208
  • ENSG00000157227

Symbol
  • MMP-14
  • MMP-X1
  • MT-MMP
  • MT1MMP
  • MTMMP1
  • WNCHRS
  • MT1-MMP
  • MT-MMP 1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
PubMedID
0.95
biological process
0.94
molecular function
0.9
disease perturbation
0.87


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1389.28   (req: < 5)
Gene RIFs: 430   (req: <= 3)
Antibodies: 974   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1389.28   (req: >= 5)
Gene RIFs: 430   (req: > 3)
Antibodies: 974   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 359
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0