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Tbio
SULT1A2
Sulfotransferase 1A2

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Is also responsible for the sulfonation and activation of minoxidil. Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Two alternatively spliced variants that encode the same protein have been described. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000335715
  • ENSP00000338742
  • ENSG00000197165
  • ENST00000395630
  • ENSP00000378992

Symbol
  • STP2
  • STP2
  • HAST4
  • P-PST
  • ST1A2
  • TSPST2
  • P-PST 2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.83
disease perturbation
0.79
chemical
0.51
phenotype
0.51
biological process
0.47


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.4   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 84.4   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (1)
1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (410)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Metabolism
Phase II - Conjugation of compounds
Protein-Protein Interactions (34)
1 – 10 of 34
SULT1A1
Tbio
Family: Enzyme
Novelty: 0.00238409
p_int: 1
Score: 0.995
Data Source: BioPlex,STRINGDB
SULT1A3
Tbio
Family: Enzyme
Novelty: 0.00335383
p_int: 0.999999993
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.868
Data Source: BioPlex,STRINGDB
PHF11
Tbio
Family: Epigenetic
Novelty: 0.05827551
p_int: 0.998588198
p_ni: 0.001411802
Score: 0.51
Data Source: BioPlex,STRINGDB
STX19
Tdark
Novelty: 0.99387951
p_int: 0.997309357
p_ni: 0.002690643
Score: 0.189
Data Source: BioPlex,STRINGDB
CALCOCO2
Tbio
Novelty: 0.01456844
p_int: 0.79730053
p_ni: 0.202699469
p_wrong: 1e-9
Score: 0.351
Data Source: BioPlex,STRINGDB
TRAPPC9
Tbio
Novelty: 0.02703008
p_int: 0.754187456
p_ni: 0.245812543
Score: 0.169
Data Source: BioPlex,STRINGDB
ADH1B
Tclin
Family: Enzyme
Novelty: 0.00204308
Score: 0.902
Data Source: STRINGDB
DIO1
Tclin
Family: Enzyme
Novelty: 0.01035036
Score: 0.902
Data Source: STRINGDB
ADH6
Tbio
Family: Enzyme
Novelty: 0.01102438
Score: 0.902
Data Source: STRINGDB
DIO2
Tbio
Family: Enzyme
Novelty: 0.00173094
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  84.40

PubMed score by year
PubTator Score  46.45

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer