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Tbio
SULT1A1
Sulfotransferase 1A1

Protein Summary
Description
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314752
  • ENSP00000321988
  • ENSG00000196502
  • ENST00000350842
  • ENSP00000329399
  • ENST00000395607
  • ENSP00000378971
  • ENST00000395609
  • ENSP00000378972
  • ENST00000569554
  • ENSP00000457912

Symbol
  • STP
  • STP1
  • PST
  • STP
  • STP1
  • P-PST
  • ST1A1
  • ST1A3
  • TSPST1
  • HAST1/HAST2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.98
kinase perturbation
0.91
transcription factor perturbation
0.91
biological term
0.71
disease perturbation
0.68


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 455.23   (req: < 5)
Gene RIFs: 118   (req: <= 3)
Antibodies: 413   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 455.23   (req: >= 5)
Gene RIFs: 118   (req: > 3)
Antibodies: 413   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (7)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat percentage
1
1
2
90.4
C-reactive protein measurement
1
1
1
88.3
red blood cell density measurement
1
1
1
80.9
intelligence
2
5
4
6.5
69.6
obese body mass index status
1
1
0
1.1
29.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body fat percentage
2
90.4
C-reactive protein measurement
1
88.3
red blood cell density measurement
1
80.9
intelligence
4
6.5
69.6
obese body mass index status
0
1.1
29.5
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:102896
20887
Rat
RGD:3767
83783
Dog
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
403892
Horse
sulfotransferase 1A1
100064221
Cow
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
282485
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Dog
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
Horse
sulfotransferase 1A1
Cow
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P50225-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (141)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Cytosolic sulfonation of small molecules
Reactome
Metabolism
Reactome
Phase II - Conjugation of compounds
Name
Explore in Pharos
Explore in Source
Biological oxidations
Cytosolic sulfonation of small molecules
Metabolism
Phase II - Conjugation of compounds
Protein-Protein Interactions (97)
1 – 10 of 97
SULT1A2
Tbio
Family: Enzyme
Novelty: 0.01102416
p_int: 1
Score: 0.995
Data Source: BioPlex,STRINGDB
SULT1A3
Tbio
Family: Enzyme
Novelty: 0.00335383
p_int: 0.99999998
p_ni: 2e-8
Score: 0.934
Data Source: BioPlex,STRINGDB
FOXR1
Tbio
Family: TF
Novelty: 0.20300395
p_int: 0.999209751
p_ni: 0.000790249
Score: 0.231
Data Source: BioPlex,STRINGDB
STAP1
Tbio
Novelty: 0.17498048
p_int: 0.998070648
p_ni: 0.001929352
Score: 0.309
Data Source: BioPlex,STRINGDB
SULT1C2
Tbio
Family: Enzyme
Novelty: 0.02956075
p_int: 0.997727654
p_ni: 0.002272345
p_wrong: 1e-9
Score: 0.88
Data Source: BioPlex,STRINGDB
SULT4A1
Tbio
Family: Enzyme
Novelty: 0.02455678
p_int: 0.993795607
p_ni: 0.006204393
Score: 0.848
Data Source: BioPlex,STRINGDB
ADH1B
Tclin
Family: Enzyme
Novelty: 0.00204308
Score: 0.913
Data Source: STRINGDB
DIO1
Tclin
Family: Enzyme
Novelty: 0.01035036
Score: 0.906
Data Source: STRINGDB
DIO2
Tbio
Family: Enzyme
Novelty: 0.00173094
Score: 0.902
Data Source: STRINGDB
ADH6
Tbio
Family: Enzyme
Novelty: 0.01102438
Score: 0.902
Data Source: STRINGDB
Publication Statistics
PubMed Score  455.23

PubMed score by year
PubTator Score  658.23

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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