Protein Summary
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]
- ENST00000314752
- ENSP00000321988
- ENSG00000196502
- ENST00000350842
- ENSP00000329399
- ENST00000395607
- ENSP00000378971
- ENST00000395609
- ENSP00000378972
- ENST00000569554
- ENSP00000457912
- STP
- STP1
- PST
- STP
- STP1
- P-PST
- ST1A1
- ST1A3
- TSPST1
- HAST1/HAST2
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 0.98 | ||
kinase perturbation | 0.91 | ||
transcription factor perturbation | 0.91 | ||
biological term | 0.71 | ||
disease perturbation | 0.68 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 462.12 (req: < 5)
Gene RIFs: 118 (req: <= 3)
Antibodies: 413 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 462.12 (req: >= 5)
Gene RIFs: 118 (req: > 3)
Antibodies: 413 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 12
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 4
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 1
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (1)
Active Ligands (4)
Protein-Protein Interactions (97)
SULT1A3
Family: Enzyme
Novelty: 0.00335383
p_int: 0.99999998
p_ni: 2e-8
Score: 0.934
Data Source: BioPlex,STRINGDB
FOXR1
Family: TF
Novelty: 0.20300395
p_int: 0.999209751
p_ni: 0.000790249
Score: 0.231
Data Source: BioPlex,STRINGDB
STAP1
Novelty: 0.17498048
p_int: 0.998070648
p_ni: 0.001929352
Score: 0.309
Data Source: BioPlex,STRINGDB
SULT1C2
Family: Enzyme
Novelty: 0.02956075
p_int: 0.997727654
p_ni: 0.002272345
p_wrong: 1e-9
Score: 0.88
Data Source: BioPlex,STRINGDB
SULT4A1
Family: Enzyme
Novelty: 0.02455678
p_int: 0.993795607
p_ni: 0.006204393
Score: 0.848
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (141)
Reactome (4)
KEGG (1)
PathwayCommons (2)
WikiPathways (134)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Cytosolic sulfonation of small molecules | ||||
Reactome | Metabolism | ||||
Reactome | Phase II - Conjugation of compounds | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Cytosolic sulfonation of small molecules | ||||
Metabolism | ||||
Phase II - Conjugation of compounds | ||||
Viral Interactions (0)
Gene Ontology Terms (13)
Functions (4)
Components (1)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Disease Associations ()
GWAS Traits (23)
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
intelligence | 3 | 16 | 8 | 6.5 | 91.1 | ||||
red blood cell density measurement | 1 | 1 | 1 | 81.6 | |||||
1 | 1 | 0 | 1.1 | 75 | |||||
2 | 1 | 0 | 1.1 | 74.2 | |||||
body fat percentage | 1 | 1 | 2 | 68 | |||||
Items per page:
1 – 5 of 23
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
intelligence | 8 | 6.5 | 91.1 | ||||
red blood cell density measurement | 1 | 81.6 | |||||
0 | 1.1 | 75 | |||||
0 | 1.1 | 74.2 | |||||
body fat percentage | 2 | 68 | |||||
Find similar targets by:
IDG Resources
Orthologs (8)
1 – 5 of 8
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:102896 | 20887 | ||||||
Rat | RGD:3767 | 83783 | ||||||
Dog | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | 403892 | ||||||
Horse | sulfotransferase 1A1 | 100064221 | ||||||
Cow | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | 282485 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | |||||
Horse | sulfotransferase 1A1 | |||||
Cow | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1 | |||||
Publication Statistics
PubMed Score 462.12
PubMed score by year
PubTator Score 658.23
PubTator score by year
Related Publications
Text Mined References (221)
GeneRif Annotations (118)
Items per page:
0 of 0
PMID | Year | Title |
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