Tbio SULT1A1 Sulfotransferase 1A1

Protein Summary

Description

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of catecholamines, phenolic drugs and neurotransmitters. Has also estrogen sulfotransferase activity. responsible for the sulfonation and activation of minoxidil. Is Mediates the metabolic activation of carcinogenic N-hydroxyarylamines to DNA binding products and could so participate as modulating factor of cancer risk. Sulfotransferase enzymes catalyze the sulfate conjugation of many hormones, neurotransmitters, drugs, and xenobiotic compounds. These cytosolic enzymes are different in their tissue distributions and substrate specificities. The gene structure (number and length of exons) is similar among family members. This gene encodes one of two phenol sulfotransferases with thermostable enzyme activity. Multiple alternatively spliced variants that encode two isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P50225
• Q2NL71
• Q86U58
• Q92818
• Q9BVU6
• Q9UGG7
• ST1A1

Gene Name

• SULT1A1

Ensembl ID

• ENST00000314752
• ENSP00000321988
• ENSG00000196502
• ENST00000350842
• ENSP00000329399
• ENST00000395607
• ENSP00000378971
• ENST00000395609
• ENSP00000378972
• ENST00000569554
• ENSP00000457912

Symbol

• STP
• STP1
• PST
• STP
• STP1
• P-PST
• ST1A1
• ST1A3
• TSPST1
• HAST1/HAST2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.98
kinase perturbation	0.91
transcription factor perturbation	0.91
biological term	0.71
disease perturbation	0.68

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 455.23   (req: < 5)

Gene RIFs: 118   (req: <= 3)

Antibodies: 413   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 455.23   (req: >= 5)

Gene RIFs: 118   (req: > 3)

Antibodies: 413   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (7)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body fat percentage	EFO_0007800	1	1	2		90.4
C-reactive protein measurement	EFO_0004458	1	1	1		88.3
red blood cell density measurement	EFO_0007978	1	1	1		80.9
intelligence	EFO_0004337	2	5	4	6.5	69.6
obese body mass index status	EFO_0007041	1	1	0	1.1	29.5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
body fat percentage	EFO_0007800	2		90.4
C-reactive protein measurement	EFO_0004458	1		88.3
red blood cell density measurement	EFO_0007978	1		80.9
intelligence	EFO_0004337	4	6.5	69.6
obese body mass index status	EFO_0007041	0	1.1	29.5

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Orthologs (8)

1 – 5 of 8

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	sulfotransferase family 1A, phenol-preferring, member 1	MGI:102896	20887
Rat	sulfotransferase family 1A member 1	RGD:3767	83783
Dog	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1		403892
Horse	sulfotransferase 1A1		100064221
Cow	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1		282485

Species	Name	OMA	EggNOG	Inparanoid
Mouse	sulfotransferase family 1A, phenol-preferring, member 1
Rat	sulfotransferase family 1A member 1
Dog	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1
Horse	sulfotransferase 1A1
Cow	sulfotransferase family, cytosolic, 1A, phenol-preferring, member 1

Protein Structure (11 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P50225-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (141)

Reactome (4)

KEGG (1)

PathwayCommons (2)

WikiPathways (134)

Biological oxidations (R-HSA-211859)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Biological oxidations	221 targets	R-HSA-211859
Reactome	Cytosolic sulfonation of small molecules	24 targets	R-HSA-156584
Reactome	Metabolism	2112 targets	R-HSA-1430728
Reactome	Phase II - Conjugation of compounds	109 targets	R-HSA-156580

Name	Explore in Pharos	Explore in Source
Biological oxidations	221 targets	R-HSA-211859
Cytosolic sulfonation of small molecules	24 targets	R-HSA-156584
Metabolism	2112 targets	R-HSA-1430728
Phase II - Conjugation of compounds	109 targets	R-HSA-156580

Gene Ontology Terms (13)

Functions (4)

Components (1)

Processes (8)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
aryl sulfotransferase activity	Inferred from Direct Assay (IDA)	UniProtKB
flavonol 3-sulfotransferase activity	Inferred from Direct Assay (IDA)	BHF-UCL
steroid sulfotransferase activity	Inferred from Direct Assay (IDA)	UniProtKB
sulfotransferase activity	Inferred from Direct Assay (IDA)	MGI

Protein-Protein Interactions (97)

Explore Interacting Targets

1 – 10 of 97

• See Interactions on String-DB

SULT1A2

Tbio

Family: Enzyme

Novelty: 0.01102416

p_int: 1

Score: 0.995

Data Source: BioPlex,STRINGDB

SULT1A3

Tbio

Family: Enzyme

Novelty: 0.00335383

p_int: 0.99999998

p_ni: 2e-8

Score: 0.934

Data Source: BioPlex,STRINGDB

FOXR1

Tbio

Family: TF

Novelty: 0.20300395

p_int: 0.999209751

p_ni: 0.000790249

Score: 0.231

Data Source: BioPlex,STRINGDB

STAP1

Tbio

Novelty: 0.17498048

p_int: 0.998070648

p_ni: 0.001929352

Score: 0.309

Data Source: BioPlex,STRINGDB

SULT1C2

Tbio

Family: Enzyme

Novelty: 0.02956075

p_int: 0.997727654

p_ni: 0.002272345

p_wrong: 1e-9

Score: 0.88

Data Source: BioPlex,STRINGDB

SULT4A1

Tbio

Family: Enzyme

Novelty: 0.02455678

p_int: 0.993795607

p_ni: 0.006204393

Score: 0.848

Data Source: BioPlex,STRINGDB

ADH1B

Tclin

Family: Enzyme

Novelty: 0.00204308

Score: 0.913

Data Source: STRINGDB

DIO1

Tclin

Family: Enzyme

Novelty: 0.01035036

Score: 0.906

Data Source: STRINGDB

DIO2

Tbio

Family: Enzyme

Novelty: 0.00173094

Score: 0.902

Data Source: STRINGDB

ADH6

Tbio

Family: Enzyme

Novelty: 0.01102438

Score: 0.902

Data Source: STRINGDB

Publication Statistics

PubMed Score  455.23

PubMed score by year

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PubTator Score  658.23

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Catecholamine metabolism
Complete proteome
Cytoplasm
Direct protein sequencing
Lipid metabolism
Phosphoprotein
Polymorphism
Reference proteome

GWAS Trait Find Similar Targets

allergic rhinitis
body fat percentage
C-reactive protein measurement
intelligence
obese body mass index status
red blood cell density measurement
risk-taking behaviour

MGI Phenotype Find Similar Targets

cellular phenotype
homeostasis/metabolism phenotype
liver/biliary system phenotype