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Tbio
MEOX1
Homeobox protein MOX-1

Protein Summary
Description
Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000318579
  • ENSP00000321684
  • ENSG00000005102
  • ENST00000329168
  • ENSP00000328678
  • ENST00000393661
  • ENSP00000377271

Symbol
  • MOX1
  • KFS2
  • MOX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
cell type or tissue
0.83
gene perturbation
0.82
disease perturbation
0.79
PubMedID
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.55   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 21.55   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Gene Ontology Terms (15)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (41)
1 – 10 of 41
MEOX2
Tbio
Family: TF
Novelty: 0.00575922
p_int: 0.999999985
p_wrong: 1.5e-8
Score: 0.726
Data Source: BioPlex,STRINGDB
CHMP1A
Tbio
Novelty: 0.06086208
p_int: 0.992855936
p_ni: 0.007143985
p_wrong: 7.8e-8
Score: 0.219
Data Source: BioPlex,STRINGDB
NIF3L1
Tbio
Novelty: 0.21052632
p_int: 0.939519181
p_ni: 0.060480667
p_wrong: 1.52e-7
Score: 0.221
Data Source: BioPlex,STRINGDB
KRT24
Tbio
Novelty: 0.05223694
Score: 0.8
Data Source: STRINGDB
PAX1
Tbio
Family: TF
Novelty: 0.00870011
Score: 0.773
Data Source: STRINGDB
SOST
Tclin
Novelty: 0.00097341
Score: 0.748
Data Source: STRINGDB
TBX6
Tbio
Family: TF
Novelty: 0.01366159
Score: 0.698
Data Source: STRINGDB
GDF3
Tbio
Novelty: 0.01421572
Score: 0.658
Data Source: STRINGDB
PAX3
Tbio
Family: TF
Novelty: 0.00139998
Score: 0.61
Data Source: STRINGDB
EYA2
Tbio
Novelty: 0.02751255
Score: 0.599
Data Source: STRINGDB
Publication Statistics
PubMed Score  21.55

PubMed score by year
PubTator Score  20.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer