Tbio MEOX1 Homeobox protein MOX-1

Protein Summary

Description

Mesodermal transcription factor that plays a key role in somitogenesis and is specifically required for sclerotome development. Required for maintenance of the sclerotome polarity and formation of the cranio-cervical joints (PubMed:23290072, PubMed:24073994). Binds specifically to the promoter of target genes and regulates their expression. Activates expression of NKX3-2 in the sclerotome. Activates expression of CDKN1A and CDKN2A in endothelial cells, acting as a regulator of vascular cell proliferation. While it activates CDKN1A in a DNA-dependent manner, it activates CDKN2A in a DNA-independent manner. Required for hematopoietic stem cell (HSCs) induction via its role in somitogenesis: specification of HSCs occurs via the deployment of a specific endothelial precursor population, which arises within a sub-compartment of the somite named endotome. This gene encodes a member of a subfamily of non-clustered, diverged, antennapedia-like homeobox-containing genes. The encoded protein may play a role in the molecular signaling network regulating somite development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P50221
• A8K524
• A8MWF9
• Q15069

Gene Name

• MEOX1

Ensembl ID

• ENST00000318579
• ENSP00000321684
• ENSG00000005102
• ENST00000329168
• ENSP00000328678
• ENST00000393661
• ENSP00000377271

Symbol

• MOX1
• KFS2
• MOX1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.91
cell type or tissue	0.83
gene perturbation	0.82
disease perturbation	0.79
PubMedID	0.76

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Homeobox Protein Mox-1

Protein / Nucleic Acid Binding / Dna Binding Protein / Homeobox Protein Mox-1

DTO Classes

Protein / Transcription Factor / Helix-turn-helix Transcription Factor / Homeodomain Transcription Factor / Homeobox Protein Mox-1

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.11   (req: < 5)

Gene RIFs: 14   (req: <= 3)

Antibodies: 340   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 41.11   (req: >= 5)

Gene RIFs: 14   (req: > 3)

Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0