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Tbio
IDH3A
Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial

Protein Summary
Description
Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers. Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehyd ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299518
  • ENSP00000299518
  • ENSG00000166411
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.94
histone modification site profile
0.89
kinase perturbation
0.88
disease perturbation
0.79
molecular function
0.7


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.14   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 250   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 40.14   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 250   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (6)
1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (13)
Citric acid cycle (TCA cycle) (R-HSA-71403)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Citric acid cycle (TCA cycle)
Reactome
Metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Citric acid cycle (TCA cycle)
Metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (157)
1 – 10 of 157
IDH3B
Tbio
Family: Enzyme
Novelty: 0.04326765
p_int: 0.999999999
p_ni: 1e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
IDH3G
Tbio
Family: Enzyme
Novelty: 0.04861242
p_int: 0.999999999
p_ni: 1e-9
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
ACO2
Tbio
Family: Enzyme
Novelty: 0.00276725
Score: 0.998
Data Source: STRINGDB
IDH2
Tclin
Family: Enzyme
Novelty: 0.00131782
Score: 0.997
Data Source: STRINGDB
IDH1
Tclin
Family: Enzyme
Novelty: 0.0004831
Score: 0.989
Data Source: STRINGDB
OGDH
Tbio
Family: Enzyme
Novelty: 0.00674601
Score: 0.985
Data Source: STRINGDB
SUCLA2
Tbio
Family: Enzyme
Novelty: 0.02029861
Score: 0.981
Data Source: STRINGDB
OGDHL
Tbio
Family: Enzyme
Novelty: 0.05079572
Score: 0.974
Data Source: STRINGDB
CS
Tbio
Family: Enzyme
Novelty: 0.00154214
Score: 0.957
Data Source: STRINGDB
ACO1
Tbio
Family: Enzyme
Novelty: 0.00194023
Score: 0.957
Data Source: STRINGDB
Publication Statistics
PubMed Score  40.14

PubMed score by year
PubTator Score  8.93

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer