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Tdark
GNG10
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374293
  • ENSP00000363411
  • ENSG00000242616

Symbol
  • GNGT10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
pathway
0.8
cell type or tissue
0.69
PubMedID
0.67
histone modification site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.49   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1.49   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Pathways (107)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 59
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Gene Ontology Terms (5)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (570)
1 – 10 of 570
GNAI3
Tbio
Novelty: 0.03936457
p_int: 0.999080745
p_ni: 0.000410941
p_wrong: 0.000508314
Score: 0.981
Data Source: BioPlex,STRINGDB
GNAI2
Tbio
Novelty: 0.04542644
p_int: 0.982240675
p_ni: 0.015610855
p_wrong: 0.00214847
Score: 0.982
Data Source: BioPlex,STRINGDB
CCR1
Tchem
Family: GPCR
Novelty: 0.00293956
p_int: 0.982240675
p_ni: 0.015610855
p_wrong: 0.00214847
Score: 0.929
Data Source: BioPlex,STRINGDB
C1QL4
Tdark
Novelty: 0.60504202
p_int: 0.943017809
p_ni: 0.032359396
p_wrong: 0.024622795
Score: 0.186
Data Source: BioPlex,STRINGDB
SLC25A41
Tdark
Family: Transporter
Novelty: 2.02597403
p_int: 0.827922978
p_ni: 0.003376264
p_wrong: 0.168700758
Data Source: BioPlex
FYTTD1
Tbio
Novelty: 0.09345794
p_int: 0.819841505
p_ni: 0.007649758
p_wrong: 0.172508737
Score: 0.183
Data Source: BioPlex,STRINGDB
GNB4
Tbio
Novelty: 0.1530232
Score: 0.999
Data Source: STRINGDB
GNB2
Tbio
Novelty: 0.20536996
Score: 0.999
Data Source: STRINGDB
GNB3
Tbio
Novelty: 0.0043523
Score: 0.999
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.04716243
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  1.49

PubMed score by year
PubTator Score  0.78

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer