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Tdark
GNG10
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-10

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. Interacts with beta-1 and beta-2, but not with beta-3.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374293
  • ENSP00000363411
  • ENSG00000242616

Symbol
  • GNGT10
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
0.84
pathway
0.8
cell type or tissue
0.69
PubMedID
0.67
histone modification site profile
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.46   (req: < 5)
Gene RIFs: 1   (req: <= 3)
Antibodies: 46   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5.46   (req: >= 5)
Gene RIFs: 1   (req: > 3)
Antibodies: 46   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (570)
GNAI3
Tbio
Novelty:  0.03484857
p_int:  0.999080745
p_ni:  0.000410941
p_wrong:  0.000508314
Score:  0.981
Data Source:  BioPlex,STRINGDB
GNAI2
Tchem
Novelty:  0.03014729
p_int:  0.982240675
p_ni:  0.015610855
p_wrong:  0.00214847
Score:  0.982
Data Source:  BioPlex,STRINGDB
CCR1
Tchem
Family:  GPCR
Novelty:  0.00218065
p_int:  0.982240675
p_ni:  0.015610855
p_wrong:  0.00214847
Score:  0.929
Data Source:  BioPlex,STRINGDB
C1QL4
Tdark
Novelty:  0.37071722
p_int:  0.943017809
p_ni:  0.032359396
p_wrong:  0.024622795
Score:  0.186
Data Source:  BioPlex,STRINGDB
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.827922978
p_ni:  0.003376264
p_wrong:  0.168700758
Data Source:  BioPlex
FYTTD1
Tbio
Novelty:  0.04600073
p_int:  0.819841505
p_ni:  0.007649758
p_wrong:  0.172508737
Score:  0.183
Data Source:  BioPlex,STRINGDB
GNB4
Tbio
Novelty:  0.08250797
Score:  0.999
Data Source:  STRINGDB
GNB2
Tbio
Novelty:  0.08682553
Score:  0.999
Data Source:  STRINGDB
GNB3
Tbio
Novelty:  0.0037117
Score:  0.999
Data Source:  STRINGDB
GNB1
Tbio
Novelty:  0.02477955
Score:  0.999
Data Source:  STRINGDB
Nearest Tclin Targets (26)
Explore Nearest Tclin Targets
1 – 5 of 16
CHRM1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CHRM2
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
F2R
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
CNR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  1
GABBR1
Tclin
Family:  GPCR
KEGG Distance:  1
Common Pathways:  2
Pathways (107)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

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Items per page:
1 – 5 of 59
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (5)
Find Similar Targets
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
59.9
bone measurement
1
1
0
26.3
29.6
BMI-adjusted fasting blood glucose measurement
1
1
1
23.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
59.9
bone measurement
0
26.3
29.6
BMI-adjusted fasting blood glucose measurement
1
23.7
IDG Resources
No IDG generated resources found
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
G protein subunit gamma 10
VGNC:13887
100611518
Mouse
MGI:1336169
14700
Rat
RGD:621514
114119
Dog
G protein subunit gamma 10
100534634
Cow
G protein subunit gamma 10
613930
Species
Name
OMA
EggNOG
Inparanoid
Chimp
G protein subunit gamma 10
Mouse
Rat
Dog
G protein subunit gamma 10
Cow
G protein subunit gamma 10
Publication Statistics
PubMed Score 5.46
PubMed score by year
PubTator Score 0.78
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title