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Tbio
GNG4
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-4

Protein Summary
Description
Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000366597
  • ENSP00000355556
  • ENSG00000168243
  • ENST00000366598
  • ENSP00000355557
  • ENST00000391854
  • ENSP00000375727
  • ENST00000450593
  • ENSP00000398629
  • ENST00000484517
  • ENSP00000482192
  • ENST00000634574
  • ENSP00000489027
  • ENSG00000282972
  • ENST00000635006
  • ENSP00000489228
  • ENST00000635235
  • ENSP00000489454
  • ENST00000635387
  • ENSP00000489307
  • ENST00000635595
  • ENSP00000489194

Symbol
  • GNGT4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.99
pathway
0.91
PubMedID
0.71
cellular component
0.7
kinase perturbation
0.6


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.37   (req: < 5)
Gene RIFs: 0   (req: <= 3)
Antibodies: 78   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6.37   (req: >= 5)
Gene RIFs: 0   (req: > 3)
Antibodies: 78   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cerebral amyloid deposition measurement
1
1
1
6.6
basophil percentage of leukocytes
1
1
1
1.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
cerebral amyloid deposition measurement
1
6.6
basophil percentage of leukocytes
1
1.5
Pathways (112)
ADP signalling through P2Y purinoceptor 1 (R-HSA-418592)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 59
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ADP signalling through P2Y purinoceptor 1
Reactome
ADP signalling through P2Y purinoceptor 12
Reactome
Activation of G protein gated Potassium channels
Reactome
Activation of GABAB receptors
Reactome
Activation of kainate receptors upon glutamate binding
Name
Explore in Pharos
Explore in Source
ADP signalling through P2Y purinoceptor 1
ADP signalling through P2Y purinoceptor 12
Activation of G protein gated Potassium channels
Activation of GABAB receptors
Activation of kainate receptors upon glutamate binding
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (558)
1 – 10 of 558
GNAI3
Tbio
Novelty: 0.03484857
p_int: 0.999999514
p_ni: 4.86e-7
Score: 0.983
Data Source: BioPlex,STRINGDB
GNAI1
Tbio
Novelty: 0.0488971
p_int: 0.999989454
p_ni: 0.000010546
Score: 0.989
Data Source: BioPlex,STRINGDB
GNAS
Tbio
Novelty: 0.00284739
p_int: 0.999985346
p_ni: 0.000014654
Score: 0.984
Data Source: BioPlex,STRINGDB
GNAI2
Tbio
Novelty: 0.03014729
p_int: 0.999962328
p_ni: 0.000037672
Score: 0.977
Data Source: BioPlex,STRINGDB
GNB4
Tbio
Novelty: 0.08250797
p_int: 0.998619542
p_ni: 0.00122695
p_wrong: 0.000153508
Score: 0.999
Data Source: BioPlex,STRINGDB
MOSPD2
Tbio
Novelty: 0.14602473
p_int: 0.997302626
p_ni: 0.002697222
p_wrong: 1.52e-7
Score: 0.179
Data Source: BioPlex,STRINGDB
GNAQ
Tbio
Novelty: 0.0008997
p_int: 0.994573176
p_ni: 0.005426824
Score: 0.958
Data Source: BioPlex,STRINGDB
PDCL
Tbio
Novelty: 0.00317454
p_int: 0.931440287
p_ni: 0.068559713
Score: 0.926
Data Source: BioPlex,STRINGDB
GNA13
Tbio
Novelty: 0.04149138
p_int: 0.844148179
p_ni: 0.096113516
p_wrong: 0.059738306
Score: 0.952
Data Source: BioPlex,STRINGDB
GNB1
Tbio
Novelty: 0.02477955
p_int: 0.823735589
p_ni: 0.176264411
Score: 0.999
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  6.37

PubMed score by year
PubTator Score  1.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer