Tchem HNMT Histamine N-methyltransferase

Protein Summary

Description

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine. In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P50135
• B2R9J3
• Q546Z6
• Q7Z7I2
• Q8IU56
• Q8WW98
• Q9BRW6
• HMT

Gene Name

• HNMT

Ensembl ID

• ENST00000280096
• ENSP00000280096
• ENSG00000150540
• ENST00000280097
• ENSP00000280097
• ENST00000329366
• ENSP00000333259
• ENST00000410115
• ENSP00000386940
• ENST00000475675
• ENSP00000419415

Symbol

• HMT
• MRT51
• HNMT-S1
• HNMT-S2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	0.91
PubMedID	0.81
microRNA	0.72
disease	0.68
phenotype	0.67

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1330.36   (req: < 5)

Gene RIFs: 42   (req: <= 3)

Antibodies: 286   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1330.36   (req: >= 5)

Gene RIFs: 42   (req: > 3)

Antibodies: 286   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1