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Tchem
KHK
Ketohexokinase

Protein Summary
Description
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260598
  • ENSP00000260598
  • ENSG00000138030
  • ENST00000260599
  • ENSP00000260599
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
disease perturbation
0.79
transcription factor binding site profile
0.71
histone modification site profile
0.67
tissue sample
0.66


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.53   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 435   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 193.53   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 435   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 15
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (13)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
3
8
8
92.5
neutrophil count
1
1
1
72.9
neutrophil percentage of leukocytes
1
1
1
68.8
lymphocyte percentage of leukocytes
1
1
1
67.1
IGF-1 measurement
1
2
2
60.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
triglyceride measurement
8
92.5
neutrophil count
1
72.9
neutrophil percentage of leukocytes
1
68.8
lymphocyte percentage of leukocytes
1
67.1
IGF-1 measurement
2
60.9
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
ketohexokinase
VGNC:285
740614
Macaque
ketohexokinase
698328
Mouse
MGI:1096353
16548
Rat
RGD:2966
25659
Dog
ketohexokinase
VGNC:42338
100170647
Species
Name
OMA
EggNOG
Inparanoid
Chimp
ketohexokinase
Macaque
ketohexokinase
Mouse
Rat
Dog
ketohexokinase
Protein Structure (19 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P50053-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (67)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Essential fructosuria
Reactome
Fructose catabolism
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Essential fructosuria
Fructose catabolism
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (73)
1 – 10 of 73
CST8
Tbio
Novelty:  0.02316886
p_int:  0.932195484
p_ni:  0.061564528
p_wrong:  0.006239988
Data Source:  BioPlex
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
p_int:  0.930771081
p_ni:  0.069228919
Score:  0.187
Data Source:  BioPlex,STRINGDB
CUEDC2
Tbio
Novelty:  0.07403123
p_int:  0.927536558
p_ni:  0.072461777
p_wrong:  0.000001664
Score:  0.416
Data Source:  BioPlex,STRINGDB
DNAJB14
Tbio
Novelty:  0.6283107
p_int:  0.909511783
p_ni:  0.090488217
Score:  0.683
Data Source:  BioPlex,STRINGDB
HK1
Tchem
Family:  Kinase
Novelty:  0.00195554
Score:  0.971
Data Source:  STRINGDB
ALDOB
Tbio
Family:  Enzyme
Novelty:  0.00856695
Score:  0.957
Data Source:  STRINGDB
SORD
Tchem
Family:  Enzyme
Novelty:  0.0040485
Score:  0.956
Data Source:  STRINGDB
ALDOC
Tbio
Family:  Enzyme
Novelty:  0.01552954
Score:  0.93
Data Source:  STRINGDB
HK2
Tchem
Family:  Kinase
Novelty:  0.00144136
Score:  0.928
Data Source:  STRINGDB
ALDOA
Tbio
Family:  Enzyme
Novelty:  0.00517474
Score:  0.927
Data Source:  STRINGDB
Publication Statistics
PubMed Score  193.53

PubMed score by year
PubTator Score  118.93

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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