Protein Classes
Protein Summary
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- ENST00000260598
- ENSP00000260598
- ENSG00000138030
- ENST00000260599
- ENSP00000260599
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
disease perturbation | 0.79 | ||
transcription factor binding site profile | 0.71 | ||
histone modification site profile | 0.67 | ||
tissue sample | 0.66 | ||
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 92.65 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 435 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 92.65 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 435 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 14
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (14)
1 – 10 of 14
Protein Data Bank (19)
1 – 5 of 19
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (67)
Reactome (8)
KEGG (2)
PathwayCommons (3)
UniProt (1)
WikiPathways (53)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | Diseases of carbohydrate metabolism | ||||
Reactome | Diseases of metabolism | ||||
Reactome | Essential fructosuria | ||||
Reactome | Fructose catabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Disease | ||||
Diseases of carbohydrate metabolism | ||||
Diseases of metabolism | ||||
Essential fructosuria | ||||
Fructose catabolism | ||||
Gene Ontology Terms (14)
Functions (3)
Components (3)
Processes (8)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (73)
1 – 10 of 73
CST8
Novelty: 0.00274495
p_int: 0.932195484
p_ni: 0.061564528
p_wrong: 0.006239988
Data Source: BioPlex
GLB1
Family: Enzyme
Novelty: 0.00274332
p_int: 0.930771081
p_ni: 0.069228919
Score: 0.187
Data Source: BioPlex,STRINGDB
CUEDC2
Novelty: 0.07761966
p_int: 0.927536558
p_ni: 0.072461777
p_wrong: 0.000001664
Score: 0.416
Data Source: BioPlex,STRINGDB
DNAJB14
Novelty: 1.08433735
p_int: 0.909511783
p_ni: 0.090488217
Score: 0.683
Data Source: BioPlex,STRINGDB
HK1
Family: Kinase
Novelty: 0.00089993
Score: 0.971
Data Source: STRINGDB
ALDOB
Family: Enzyme
Novelty: 0.01088525
Score: 0.957
Data Source: STRINGDB
SORD
Family: Enzyme
Novelty: 0.00508278
Score: 0.956
Data Source: STRINGDB
ALDOC
Family: Enzyme
Novelty: 0.02143701
Score: 0.93
Data Source: STRINGDB
HK2
Family: Kinase
Novelty: 0.00222818
Score: 0.928
Data Source: STRINGDB
ALDOA
Family: Enzyme
Novelty: 0.00698688
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score 92.65
PubMed score by year
PubTator Score 118.93
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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