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Tchem
KHK
Ketohexokinase

Protein Summary
Description
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000260598
  • ENSP00000260598
  • ENSG00000138030
  • ENST00000260599
  • ENSP00000260599
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
disease perturbation
0.79
transcription factor binding site profile
0.71
histone modification site profile
0.67
tissue sample
0.66


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.65   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 435   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 92.65   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 435   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 14
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (19)
1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (67)
Disease (R-HSA-1643685)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Disease
Reactome
Diseases of carbohydrate metabolism
Reactome
Diseases of metabolism
Reactome
Essential fructosuria
Reactome
Fructose catabolism
Name
Explore in Pharos
Explore in Source
Disease
Diseases of carbohydrate metabolism
Diseases of metabolism
Essential fructosuria
Fructose catabolism
Gene Ontology Terms (14)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
MGI
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (73)
1 – 10 of 73
CST8
Tbio
Novelty: 0.00274495
p_int: 0.932195484
p_ni: 0.061564528
p_wrong: 0.006239988
Data Source: BioPlex
GLB1
Tchem
Family: Enzyme
Novelty: 0.00274332
p_int: 0.930771081
p_ni: 0.069228919
Score: 0.187
Data Source: BioPlex,STRINGDB
CUEDC2
Tbio
Novelty: 0.07761966
p_int: 0.927536558
p_ni: 0.072461777
p_wrong: 0.000001664
Score: 0.416
Data Source: BioPlex,STRINGDB
DNAJB14
Tbio
Novelty: 1.08433735
p_int: 0.909511783
p_ni: 0.090488217
Score: 0.683
Data Source: BioPlex,STRINGDB
HK1
Tchem
Family: Kinase
Novelty: 0.00089993
Score: 0.971
Data Source: STRINGDB
ALDOB
Tbio
Family: Enzyme
Novelty: 0.01088525
Score: 0.957
Data Source: STRINGDB
SORD
Tchem
Family: Enzyme
Novelty: 0.00508278
Score: 0.956
Data Source: STRINGDB
ALDOC
Tbio
Family: Enzyme
Novelty: 0.02143701
Score: 0.93
Data Source: STRINGDB
HK2
Tchem
Family: Kinase
Novelty: 0.00222818
Score: 0.928
Data Source: STRINGDB
ALDOA
Tbio
Family: Enzyme
Novelty: 0.00698688
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score  92.65

PubMed score by year
PubTator Score  118.93

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer