Protein Summary
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- ENST00000260598
- ENSP00000260598
- ENSG00000138030
- ENST00000260599
- ENSP00000260599
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
disease perturbation | 0.79 | ||
transcription factor binding site profile | 0.71 | ||
histone modification site profile | 0.67 | ||
tissue sample | 0.66 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 193.53 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 435 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 193.53 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 435 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 15
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (15)
Protein-Protein Interactions (73)
CST8
Novelty: 0.02316886
p_int: 0.932195484
p_ni: 0.061564528
p_wrong: 0.006239988
Data Source: BioPlex
GLB1
Family: Enzyme
Novelty: 0.00241713
p_int: 0.930771081
p_ni: 0.069228919
Score: 0.187
Data Source: BioPlex,STRINGDB
CUEDC2
Novelty: 0.07403123
p_int: 0.927536558
p_ni: 0.072461777
p_wrong: 0.000001664
Score: 0.416
Data Source: BioPlex,STRINGDB
DNAJB14
Novelty: 0.6283107
p_int: 0.909511783
p_ni: 0.090488217
Score: 0.683
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets (1)
Upstream (1)
1 – 1 of 1
Pathways (67)
Reactome (8)
KEGG (2)
PathwayCommons (3)
UniProt (1)
WikiPathways (53)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | Diseases of carbohydrate metabolism | ||||
Reactome | Diseases of metabolism | ||||
Reactome | Essential fructosuria | ||||
Reactome | Fructose catabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Disease | ||||
Diseases of carbohydrate metabolism | ||||
Diseases of metabolism | ||||
Essential fructosuria | ||||
Fructose catabolism | ||||
Viral Interactions (0)
Gene Ontology Terms (14)
Functions (3)
Components (3)
Processes (8)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (13)
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 3 | 8 | 8 | 92.5 | |||||
neutrophil count | 1 | 1 | 1 | 72.9 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 68.8 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 67.1 | |||||
IGF-1 measurement | 1 | 2 | 2 | 60.9 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 8 | 92.5 | |||||
neutrophil count | 1 | 72.9 | |||||
neutrophil percentage of leukocytes | 1 | 68.8 | |||||
lymphocyte percentage of leukocytes | 1 | 67.1 | |||||
IGF-1 measurement | 2 | 60.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ketohexokinase | VGNC:285 | 740614 | |||||
Macaque | ketohexokinase | 698328 | ||||||
Mouse | MGI:1096353 | 16548 | ||||||
Rat | RGD:2966 | 25659 | ||||||
Dog | ketohexokinase | VGNC:42338 | 100170647 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ketohexokinase | |||||
Macaque | ketohexokinase | |||||
Mouse | ||||||
Rat | ||||||
Dog | ketohexokinase | |||||
Publication Statistics
PubMed Score 193.53
PubMed score by year
PubTator Score 118.93
PubTator score by year
Patents
Patents by year
Related Publications
Text Mined References (33)
GeneRif Annotations (13)
Items per page:
0 of 0
PMID | Year | Title |
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