Protein Classes
Protein Summary
Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. This gene encodes ketohexokinase that catalyzes conversion of fructose to fructose-1-phosphate. The product of this gene is the first enzyme with a specialized pathway that catabolizes dietary fructose. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
- ENST00000260598
- ENSP00000260598
- ENSG00000138030
- ENST00000260599
- ENSP00000260599
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
disease perturbation | 0.79 | ||
transcription factor binding site profile | 0.71 | ||
histone modification site profile | 0.67 | ||
tissue sample | 0.66 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 193.53 (req: < 5)
Gene RIFs: 13 (req: <= 3)
Antibodies: 435 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 193.53 (req: >= 5)
Gene RIFs: 13 (req: > 3)
Antibodies: 435 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 11
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 15
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (15)
1 – 10 of 15
GWAS Traits (13)
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1 – 5 of 13
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
triglyceride measurement | 3 | 8 | 8 | 92.5 | |||||
neutrophil count | 1 | 1 | 1 | 72.9 | |||||
neutrophil percentage of leukocytes | 1 | 1 | 1 | 68.8 | |||||
lymphocyte percentage of leukocytes | 1 | 1 | 1 | 67.1 | |||||
IGF-1 measurement | 1 | 2 | 2 | 60.9 | |||||
Items per page:
1 – 5 of 13
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
triglyceride measurement | 8 | 92.5 | |||||
neutrophil count | 1 | 72.9 | |||||
neutrophil percentage of leukocytes | 1 | 68.8 | |||||
lymphocyte percentage of leukocytes | 1 | 67.1 | |||||
IGF-1 measurement | 2 | 60.9 | |||||
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | ketohexokinase | VGNC:285 | 740614 | |||||
Macaque | ketohexokinase | 698328 | ||||||
Mouse | MGI:1096353 | 16548 | ||||||
Rat | RGD:2966 | 25659 | ||||||
Dog | ketohexokinase | VGNC:42338 | 100170647 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | ketohexokinase | |||||
Macaque | ketohexokinase | |||||
Mouse | ||||||
Rat | ||||||
Dog | ketohexokinase | |||||
Protein Structure (19 Structures, 1 AlphaFold Model)
Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB
1 – 5 of 19
PDB Structure Id | Ligand | Method | Resolution (Å) | Residues | Fraction of Total Protein | Pub Year | Title |
|---|
PDB Structure Id | Fraction of Total Protein | Resolution | Pub Year |
|---|
Pathways (67)
Reactome (8)
KEGG (2)
PathwayCommons (3)
UniProt (1)
WikiPathways (53)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 8
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Disease | ||||
Reactome | Diseases of carbohydrate metabolism | ||||
Reactome | Diseases of metabolism | ||||
Reactome | Essential fructosuria | ||||
Reactome | Fructose catabolism | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Disease | ||||
Diseases of carbohydrate metabolism | ||||
Diseases of metabolism | ||||
Essential fructosuria | ||||
Fructose catabolism | ||||
Gene Ontology Terms (14)
Functions (3)
Components (3)
Processes (8)
Items per page:
10
1 – 3 of 3
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Protein-Protein Interactions (73)
1 – 10 of 73
CST8
Novelty: 0.02316886
p_int: 0.932195484
p_ni: 0.061564528
p_wrong: 0.006239988
Data Source: BioPlex
GLB1
Family: Enzyme
Novelty: 0.00241713
p_int: 0.930771081
p_ni: 0.069228919
Score: 0.187
Data Source: BioPlex,STRINGDB
CUEDC2
Novelty: 0.07403123
p_int: 0.927536558
p_ni: 0.072461777
p_wrong: 0.000001664
Score: 0.416
Data Source: BioPlex,STRINGDB
DNAJB14
Novelty: 0.6283107
p_int: 0.909511783
p_ni: 0.090488217
Score: 0.683
Data Source: BioPlex,STRINGDB
HK1
Family: Kinase
Novelty: 0.00195554
Score: 0.971
Data Source: STRINGDB
ALDOB
Family: Enzyme
Novelty: 0.00856695
Score: 0.957
Data Source: STRINGDB
SORD
Family: Enzyme
Novelty: 0.0040485
Score: 0.956
Data Source: STRINGDB
ALDOC
Family: Enzyme
Novelty: 0.01552954
Score: 0.93
Data Source: STRINGDB
HK2
Family: Kinase
Novelty: 0.00144136
Score: 0.928
Data Source: STRINGDB
ALDOA
Family: Enzyme
Novelty: 0.00517474
Score: 0.927
Data Source: STRINGDB
Publication Statistics
PubMed Score 193.53
PubMed score by year
PubTator Score 118.93
PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword
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GWAS Trait
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