You are using an outdated browser. Please upgrade your browser to improve your experience.

Tchem
P4HB
Protein disulfide-isomerase

Protein Summary
Description
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migrati ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331483
  • ENSP00000327801
  • ENSG00000185624

Symbol
  • ERBA2L
  • PDI
  • PDIA1
  • PO4DB
  • DSI
  • GIT
  • PDI
  • PHDB
  • PDIA1
  • PO4DB
  • PO4HB
  • PROHB
  • CLCRP1
  • ERBA2L
  • P4Hbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
cellular component
0.97
transcription factor perturbation
0.94
molecular function
0.9
virus perturbation
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1238.67   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 483   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1238.67   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 483   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 84
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0