Tchem P4HB Protein disulfide-isomerase

Protein Summary

Description

This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migration (PubMed:21670307). This gene encodes the beta subunit of prolyl 4-hydroxylase, a highly abundant multifunctional enzyme that belongs to the protein disulfide isomerase family. When present as a tetramer consisting of two alpha and two beta subunits, this enzyme is involved in hydroxylation of prolyl residues in preprocollagen. This enzyme is also a disulfide isomerase containing two thioredoxin domains that catalyze the formation, breakage and rearrangement of disulfide bonds. Other known functions include its ability to act as a chaperone that inhibits aggregation of misfolded proteins in a concentration-dependent manner, its ability to bind thyroid hormone, its role in both the influx and efflux of S-nitrosothiol-bound nitric oxide, and its function as a subunit of the microsomal triglyceride transfer protein complex. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P07237
• B2RDQ2
• P30037
• P32079
• Q15205
• Q6LDE5
• PDI

Gene Name

• P4HB

Ensembl ID

• ENST00000331483
• ENSP00000327801
• ENSG00000185624

Symbol

• ERBA2L
• PDI
• PDIA1
• PO4DB
• DSI
• GIT
• PDI
• PHDB
• PDIA1
• PO4DB
• PO4HB
• PROHB
• CLCRP1
• ERBA2L
• P4Hbeta

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
metabolite	1
cellular component	0.97
transcription factor perturbation	0.94
molecular function	0.9
virus perturbation	0.9

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1238.67   (req: < 5)

Gene RIFs: 58   (req: <= 3)

Antibodies: 483   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1238.67   (req: >= 5)

Gene RIFs: 58   (req: > 3)

Antibodies: 483   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 84

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0