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Tchem
P4HB
Protein disulfide-isomerase

Protein Summary
Description
This multifunctional protein catalyzes the formation, breakage and rearrangement of disulfide bonds. At the cell surface, seems to act as a reductase that cleaves disulfide bonds of proteins attached to the cell. May therefore cause structural modifications of exofacial proteins. Inside the cell, seems to form/rearrange disulfide bonds of nascent proteins. At high concentrations, functions as a chaperone that inhibits aggregation of misfolded proteins. At low concentrations, facilitates aggregation (anti-chaperone activity). May be involved with other chaperones in the structural modification of the TG precursor in hormone biogenesis. Also acts a structural subunit of various enzymes such as prolyl 4-hydroxylase and microsomal triacylglycerol transfer protein MTTP. Receptor for LGALS9; the interaction retains P4HB at the cell surface of Th2 T helper cells, increasing disulfide reductase activity at the plasma membrane, altering the plasma membrane redox state and enhancing cell migrati ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331483
  • ENSP00000327801
  • ENSG00000185624

Symbol
  • ERBA2L
  • PDI
  • PDIA1
  • PO4DB
  • DSI
  • GIT
  • PDI
  • PHDB
  • PDIA1
  • PO4DB
  • PO4HB
  • PROHB
  • CLCRP1
  • ERBA2L
  • P4Hbeta
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
cellular component
0.97
transcription factor perturbation
0.94
molecular function
0.9
virus perturbation
0.9


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 944.31   (req: < 5)
Gene RIFs: 34   (req: <= 3)
Antibodies: 483   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 944.31   (req: >= 5)
Gene RIFs: 34   (req: > 3)
Antibodies: 483   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 25
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (421)
TRIM4
Tbio
Family:  Enzyme
Novelty:  0.11398363
p_int:  0.999990521
p_ni:  0.000009479
Score:  0.38
Data Source:  BioPlex,STRINGDB
SUCO
Tdark
Novelty:  0.00074481
p_int:  0.999771614
p_ni:  0.000228367
p_wrong:  1.9e-8
Score:  0.558
Data Source:  BioPlex,STRINGDB
ZBTB2
Tbio
Family:  TF
Novelty:  0.12299559
p_int:  0.995081591
p_ni:  0.000545878
p_wrong:  0.004372531
Score:  0.284
Data Source:  BioPlex,STRINGDB
P4HA2
Tbio
Family:  Enzyme
Novelty:  0.02097718
p_int:  0.995002526
p_ni:  0.004997474
Score:  0.985
Data Source:  BioPlex,Reactome,STRINGDB
GXYLT1
Tdark
Family:  Enzyme
Novelty:  0.39064064
p_int:  0.991169481
p_ni:  0.008830519
Score:  0.216
Data Source:  BioPlex,STRINGDB
P4HA3
Tbio
Family:  Enzyme
Novelty:  0.03832564
p_int:  0.946878711
p_ni:  0.053121289
Score:  0.994
Data Source:  BioPlex,Reactome,STRINGDB
P4HA1
Tchem
Family:  Enzyme
Novelty:  0.01624726
p_int:  0.849892388
p_ni:  0.150107612
Score:  0.981
Data Source:  BioPlex,Reactome,STRINGDB
HRG
Tbio
Novelty:  0.0027048
p_int:  0.791080168
p_ni:  0.208919832
Score:  0.197
Data Source:  BioPlex,STRINGDB
CALR
Tbio
Novelty:  0.0004479
Score:  0.999
Data Source:  STRINGDB
HSP90B1
Tchem
Novelty:  0.00135881
Score:  0.998
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (25)
Cellular responses to external stimuli (R-HSA-8953897)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 24
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Chylomicron assembly
Reactome
Collagen biosynthesis and modifying enzymes
Reactome
Collagen formation
Name
Explore in Pharos
Explore in Source
Cellular responses to external stimuli
Cellular responses to stress
Chylomicron assembly
Collagen biosynthesis and modifying enzymes
Collagen formation
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (30)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CACAO
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
2
2
55.2
hemoglobin measurement
1
1
1
47.7
hair color
1
1
0
1.1
28.1
BMI-adjusted waist-hip ratio
1
1
1
14.2
birth weight
1
1
1
12.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
hematocrit
2
55.2
hemoglobin measurement
1
47.7
hair color
0
1.1
28.1
BMI-adjusted waist-hip ratio
1
14.2
birth weight
1
12.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
prolyl 4-hydroxylase subunit beta
VGNC:9501
454970
Macaque
prolyl 4-hydroxylase subunit beta
714702
Mouse
MGI:97464
18453
Rat
RGD:3244
25506
Dog
prolyl 4-hydroxylase subunit beta
VGNC:44225
483369
Species
Name
OMA
EggNOG
Inparanoid
Chimp
prolyl 4-hydroxylase subunit beta
Macaque
prolyl 4-hydroxylase subunit beta
Mouse
Rat
Dog
prolyl 4-hydroxylase subunit beta
Publication Statistics
PubMed Score 944.31
PubMed score by year
PubTator Score 668.00
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title