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Tchem
ENTPD1
Ectonucleoside triphosphate diphosphohydrolase 1

Protein Summary
Description
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371205
  • ENSP00000360248
  • ENSG00000138185
  • ENST00000371207
  • ENSP00000360250
  • ENST00000453258
  • ENSP00000390955
  • ENST00000543964
  • ENSP00000442968

Symbol
  • CD39
  • CD39
  • SPG64
  • ATPDase
  • NTPDase-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.91
biological term
0.77
PubMedID
0.74
tissue sample
0.69
microRNA
0.65


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 799.54   (req: < 5)
Gene RIFs: 98   (req: <= 3)
Antibodies: 757   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 799.54   (req: >= 5)
Gene RIFs: 98   (req: > 3)
Antibodies: 757   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 13
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (2)
1 – 2 of 2
PSB-0963
chemical structure image
ARL 67156
chemical structure image
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
1
1
9
45.8
platelet count
1
1
1
27
platelet crit
1
1
1
23
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
electrocardiography
9
45.8
platelet count
1
27
platelet crit
1
23
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
ectonucleoside triphosphate diphosphohydrolase 1
703591
Mouse
MGI:102805
12495
Rat
RGD:69265
64519
Dog
ectonucleoside triphosphate diphosphohydrolase 1
486810
Horse
ectonucleoside triphosphate diphosphohydrolase 1
100070956
Species
Name
OMA
EggNOG
Inparanoid
Macaque
ectonucleoside triphosphate diphosphohydrolase 1
Mouse
Rat
Dog
ectonucleoside triphosphate diphosphohydrolase 1
Horse
ectonucleoside triphosphate diphosphohydrolase 1
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P49961-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase catabolism
Reactome
Phosphate bond hydrolysis by NTPDase proteins
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase catabolism
Phosphate bond hydrolysis by NTPDase proteins
Gene Ontology Terms (17)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Protein-Protein Interactions (275)
1 – 10 of 275
ENPP1
Tchem
Family: Enzyme
Novelty: 0.00256132
Score: 0.965
Data Source: STRINGDB
NT5E
Tchem
Family: Enzyme
Novelty: 0.00083237
Score: 0.963
Data Source: STRINGDB
ADK
Tchem
Family: Kinase
Novelty: 0.00196435
Score: 0.958
Data Source: STRINGDB
ENPP3
Tbio
Family: Enzyme
Novelty: 0.00414129
Score: 0.956
Data Source: STRINGDB
ITPA
Tbio
Family: Enzyme
Novelty: 0.00235169
Score: 0.947
Data Source: STRINGDB
AMPD2
Tchem
Family: Enzyme
Novelty: 0.01510718
Score: 0.929
Data Source: STRINGDB
NTPCR
Tbio
Family: Enzyme
Novelty: 0.0638186
Score: 0.925
Data Source: STRINGDB
ATIC
Tchem
Novelty: 0.00466845
Score: 0.92
Data Source: STRINGDB
ADSL
Tbio
Family: Enzyme
Novelty: 0.0028496
Score: 0.915
Data Source: STRINGDB
UCK1
Tbio
Family: Kinase
Novelty: 0.10536869
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score  799.54

PubMed score by year
PubTator Score  357.8

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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