ENTPD1
Ectonucleoside triphosphate diphosphohydrolase 1
Protein Summary
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
- ENST00000371205
- ENSP00000360248
- ENSG00000138185
- ENST00000371207
- ENSP00000360250
- ENST00000453258
- ENSP00000390955
- ENST00000543964
- ENSP00000442968
- CD39
- CD39
- SPG64
- ATPDase
- NTPDase-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
biological term | 0.77 | ||
PubMedID | 0.74 | ||
tissue sample | 0.69 | ||
microRNA | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 915.43 (req: < 5)
Gene RIFs: 143 (req: <= 3)
Antibodies: 757 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 915.43 (req: >= 5)
Gene RIFs: 143 (req: > 3)
Antibodies: 757 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 5
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0