ENTPD1
Ectonucleoside triphosphate diphosphohydrolase 1
Protein Summary
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
- ENST00000371205
- ENSP00000360248
- ENSG00000138185
- ENST00000371207
- ENSP00000360250
- ENST00000453258
- ENSP00000390955
- ENST00000543964
- ENSP00000442968
- CD39
- CD39
- SPG64
- ATPDase
- NTPDase-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
biological term | 0.77 | ||
PubMedID | 0.74 | ||
tissue sample | 0.69 | ||
microRNA | 0.65 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 830.92 (req: < 5)
Gene RIFs: 98 (req: <= 3)
Antibodies: 757 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 830.92 (req: >= 5)
Gene RIFs: 98 (req: > 3)
Antibodies: 757 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (2)
Protein-Protein Interactions (275)
Nearest Tclin Targets (42)
Upstream (30)
Downstream (12)
1 – 5 of 30
Pathways (11)
Reactome (4)
KEGG (4)
PathwayCommons (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Nucleobase catabolism | ||||
Reactome | Phosphate bond hydrolysis by NTPDase proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Nucleobase catabolism | ||||
Phosphate bond hydrolysis by NTPDase proteins | ||||
Viral Interactions (0)
Gene Ontology Terms (17)
Functions (10)
Components (4)
Processes (3)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
electrocardiography | 1 | 1 | 9 | 64 | |||||
platelet count | 1 | 1 | 1 | 55.2 | |||||
platelet crit | 1 | 1 | 1 | 50.6 | |||||
blood metabolite measurement | 1 | 1 | 1 | 45.7 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
electrocardiography | 9 | 64 | |||||
platelet count | 1 | 55.2 | |||||
platelet crit | 1 | 50.6 | |||||
blood metabolite measurement | 1 | 45.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | ectonucleoside triphosphate diphosphohydrolase 1 | 703591 | ||||||
Mouse | MGI:102805 | 12495 | ||||||
Rat | RGD:69265 | 64519 | ||||||
Dog | ectonucleoside triphosphate diphosphohydrolase 1 | 486810 | ||||||
Horse | ectonucleoside triphosphate diphosphohydrolase 1 | 100070956 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | ectonucleoside triphosphate diphosphohydrolase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ectonucleoside triphosphate diphosphohydrolase 1 | |||||
Horse | ectonucleoside triphosphate diphosphohydrolase 1 | |||||
Publication Statistics
PubMed Score 830.92
PubMed score by year
PubTator Score 357.80
PubTator score by year
Related Publications
Text Mined References (117)
GeneRif Annotations (98)
Items per page:
0 of 0
PMID | Year | Title |
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