ENTPD1
Ectonucleoside triphosphate diphosphohydrolase 1
Protein Classes
Protein Summary
In the nervous system, could hydrolyze ATP and other nucleotides to regulate purinergic neurotransmission. Could also be implicated in the prevention of platelet aggregation by hydrolyzing platelet-activating ADP to AMP. Hydrolyzes ATP and ADP equally well. The protein encoded by this gene is a plasma membrane protein that hydrolyzes extracellular ATP and ADP to AMP. Inhibition of this protein's activity may confer anticancer benefits. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2015]
- ENST00000371205
- ENSP00000360248
- ENSG00000138185
- ENST00000371207
- ENSP00000360250
- ENST00000453258
- ENSP00000390955
- ENST00000543964
- ENSP00000442968
- CD39
- CD39
- SPG64
- ATPDase
- NTPDase-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
biological term | 0.77 | ||
PubMedID | 0.74 | ||
tissue sample | 0.69 | ||
microRNA | 0.65 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 799.54 (req: < 5)
Gene RIFs: 98 (req: <= 3)
Antibodies: 757 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 799.54 (req: >= 5)
Gene RIFs: 98 (req: > 3)
Antibodies: 757 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 13
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 2
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Active Ligands (2)
1 – 2 of 2
GWAS Traits (3)
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
electrocardiography | 1 | 1 | 9 | 45.8 | |||||
platelet count | 1 | 1 | 1 | 27 | |||||
platelet crit | 1 | 1 | 1 | 23 | |||||
Items per page:
1 – 3 of 3
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
electrocardiography | 9 | 45.8 | |||||
platelet count | 1 | 27 | |||||
platelet crit | 1 | 23 | |||||
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Macaque | ectonucleoside triphosphate diphosphohydrolase 1 | 703591 | ||||||
Mouse | MGI:102805 | 12495 | ||||||
Rat | RGD:69265 | 64519 | ||||||
Dog | ectonucleoside triphosphate diphosphohydrolase 1 | 486810 | ||||||
Horse | ectonucleoside triphosphate diphosphohydrolase 1 | 100070956 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Macaque | ectonucleoside triphosphate diphosphohydrolase 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | ectonucleoside triphosphate diphosphohydrolase 1 | |||||
Horse | ectonucleoside triphosphate diphosphohydrolase 1 | |||||
Protein Structure (0 Structures, 1 AlphaFold Model)
Pathways (11)
Reactome (4)
KEGG (4)
PathwayCommons (2)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Metabolism | ||||
Reactome | Metabolism of nucleotides | ||||
Reactome | Nucleobase catabolism | ||||
Reactome | Phosphate bond hydrolysis by NTPDase proteins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Metabolism | ||||
Metabolism of nucleotides | ||||
Nucleobase catabolism | ||||
Phosphate bond hydrolysis by NTPDase proteins | ||||
Gene Ontology Terms (17)
Functions (10)
Components (4)
Processes (3)
Items per page:
10
1 – 10 of 10
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Experiment (EXP) | Reactome | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Protein-Protein Interactions (275)
1 – 10 of 275
ENPP1
Family: Enzyme
Novelty: 0.00256132
Score: 0.965
Data Source: STRINGDB
NT5E
Family: Enzyme
Novelty: 0.00083237
Score: 0.963
Data Source: STRINGDB
ADK
Family: Kinase
Novelty: 0.00196435
Score: 0.958
Data Source: STRINGDB
ENPP3
Family: Enzyme
Novelty: 0.00414129
Score: 0.956
Data Source: STRINGDB
ITPA
Family: Enzyme
Novelty: 0.00235169
Score: 0.947
Data Source: STRINGDB
AMPD2
Family: Enzyme
Novelty: 0.01510718
Score: 0.929
Data Source: STRINGDB
NTPCR
Family: Enzyme
Novelty: 0.0638186
Score: 0.925
Data Source: STRINGDB
ATIC
Novelty: 0.00466845
Score: 0.92
Data Source: STRINGDB
ADSL
Family: Enzyme
Novelty: 0.0028496
Score: 0.915
Data Source: STRINGDB
UCK1
Family: Kinase
Novelty: 0.10536869
Score: 0.913
Data Source: STRINGDB
Publication Statistics
PubMed Score 799.54
PubMed score by year
PubTator Score 357.8
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
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UniProt Keyword