You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MRE11
Double-strand break repair protein MRE11

Protein Summary
Description
Component of the MRN complex, which plays a central role in double-strand break (DSB) repair, DNA recombination, maintenance of telomere integrity and meiosis. The complex possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity, which are provided by MRE11. RAD50 may be required to bind DNA ends and hold them in close proximity. This could facilitate searches for short or long regions of sequence homology in the recombining DNA templates, and may also stimulate the activity of DNA ligases and/or restrict the nuclease activity of MRE11 to prevent nucleolytic degradation past a given point (PubMed:9651580, PubMed:9590181, PubMed:9705271, PubMed:11741547, PubMed:29670289). The complex may also be required for DNA damage signaling via activation of the ATM kinase (PubMed:15064416). In telomeres the MRN complex may modulate t-loop formation (PubMed:10888888). This gene encodes a nuclear protein involved in homologous recombination, telomere length ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000323929
  • ENSP00000325863
  • ENSG00000020922
  • ENST00000323977
  • ENSP00000326094
  • ENST00000407439
  • ENSP00000385614

Symbol
  • HNGS1
  • MRE11A
  • ATLD
  • HNGS1
  • MRE11A
  • MRE11B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.59   (req: < 5)
Gene RIFs: 151   (req: <= 3)
Antibodies: 638   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 88.59   (req: >= 5)
Gene RIFs: 151   (req: > 3)
Antibodies: 638   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (3)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (279)
FAM219A
Tdark
Novelty:  12.35294118
p_int:  0.99971636
p_ni:  0.00028364
Score:  0.198
Data Source:  BioPlex,STRINGDB
BMP1
Tchem
Novelty:  0.00299518
p_int:  0.999071688
p_ni:  0.000928312
Score:  0.187
Data Source:  BioPlex,STRINGDB
RGS20
Tbio
Novelty:  0.04087618
p_int:  0.99546047
p_ni:  0.00453953
Data Source:  BioPlex
CELA2B
Tdark
Family:  Enzyme
Novelty:  0.43122129
p_int:  0.993764569
p_ni:  0.006235431
Score:  0.253
Data Source:  BioPlex,STRINGDB
RAB43
Tbio
Family:  Enzyme
Novelty:  0.07527576
p_int:  0.912110507
p_ni:  0.087889493
Data Source:  BioPlex
SCG3
Tbio
Novelty:  0.02153066
p_int:  0.882548159
p_ni:  0.117451841
Score:  0.282
Data Source:  BioPlex,STRINGDB
RAD50
Tbio
Novelty:  0.02161298
Score:  0.999
Data Source:  Reactome,STRINGDB
NBN
Tbio
Novelty:  0.00759456
Score:  0.999
Data Source:  Reactome,STRINGDB
XRCC6
Tbio
Novelty:  0.00127955
Score:  0.997
Data Source:  Reactome,STRINGDB
TERF2IP
Tchem
Novelty:  0.06285957
Score:  0.996
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (60)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 39
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle Checkpoints
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle Checkpoints
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (48)
Find Similar Targets
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
CACAO
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
CACAO
Inferred from Direct Assay (IDA)
CACAO
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
BHF-UCL
Disease Associations (null)
No disease associations found
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
1
4
83.5
IGF-1 measurement
1
1
1
30.2
1
1
1
0.9
sleep apnea measurement
1
1
1
0.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
testosterone measurement
4
83.5
IGF-1 measurement
1
30.2
1
0.9
sleep apnea measurement
1
0.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (16)
1 – 5 of 16
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MRE11 homolog, double strand break repair nuclease
VGNC:3107
737902
Macaque
MRE11 homolog, double strand break repair nuclease
697566
Mouse
MGI:1100512
17535
Rat
RGD:69263
64046
Dog
MRE11 homolog, double strand break repair nuclease
VGNC:43361
494006
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MRE11 homolog, double strand break repair nuclease
Macaque
MRE11 homolog, double strand break repair nuclease
Mouse
Rat
Dog
MRE11 homolog, double strand break repair nuclease
Publication Statistics
PubMed Score 88.59
PubMed score by year
PubTator Score 375.55
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title