Tbio CDKN1C Cyclin-dependent kinase inhibitor 1C

Protein Summary

Description

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• P49918

Gene Name

• CDKN1C

Ensembl ID

• ENST00000414822
• ENSP00000413720
• ENSG00000129757
• ENST00000430149
• ENSP00000411552
• ENST00000440480
• ENSP00000411257

Symbol

• KIP2
• BWS
• WBS
• p57
• BWCR
• KIP2
• p57Kip2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
small molecule perturbation	0.94
biological process	0.91
transcription factor perturbation	0.91
biological term	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 559.55   (req: < 5)

Gene RIFs: 193   (req: <= 3)

Antibodies: 1047   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 559.55   (req: >= 5)

Gene RIFs: 193   (req: > 3)

Antibodies: 1047   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0