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Tbio
CDKN1C
Cyclin-dependent kinase inhibitor 1C

Protein Summary
Description
Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000414822
  • ENSP00000413720
  • ENSG00000129757
  • ENST00000430149
  • ENSP00000411552
  • ENST00000440480
  • ENSP00000411257

Symbol
  • KIP2
  • BWS
  • WBS
  • p57
  • BWCR
  • KIP2
  • p57Kip2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
small molecule perturbation
0.94
biological process
0.91
transcription factor perturbation
0.91
biological term
0.74


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 509.2   (req: < 5)
Gene RIFs: 153   (req: <= 3)
Antibodies: 1047   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 509.2   (req: >= 5)
Gene RIFs: 153   (req: > 3)
Antibodies: 1047   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (127)
CCND3
Tchem
Novelty:  0.00223085
p_int:  0.999999713
p_ni:  2.27e-7
p_wrong:  6e-8
Score:  0.991
Data Source:  BioPlex,STRINGDB
CCND1
Tchem
Novelty:  0.0001186
p_int:  0.999999617
p_ni:  3.82e-7
p_wrong:  1e-9
Score:  0.992
Data Source:  BioPlex,STRINGDB
CDK2
Tchem
Family:  Kinase
Novelty:  0.00032118
p_int:  0.99998806
p_ni:  8.74e-7
p_wrong:  0.000011066
Score:  0.995
Data Source:  BioPlex,STRINGDB
CCNA2
Tchem
Novelty:  0.00049887
p_int:  0.999876072
p_ni:  0.000123865
p_wrong:  6.3e-8
Score:  0.987
Data Source:  BioPlex,STRINGDB
CDK3
Tchem
Family:  Kinase
Novelty:  0.03380289
p_int:  0.999846029
p_ni:  0.000153691
p_wrong:  2.8e-7
Score:  0.753
Data Source:  BioPlex,STRINGDB
CCND2
Tbio
Novelty:  0.00157305
p_int:  0.999835629
p_ni:  0.000001221
p_wrong:  0.000163151
Score:  0.986
Data Source:  BioPlex,STRINGDB
CDK6
Tclin
Family:  Kinase
Novelty:  0.00109319
p_int:  0.999318414
p_ni:  0.0006517
p_wrong:  0.000029886
Score:  0.989
Data Source:  BioPlex,STRINGDB
CDK1
Tchem
Family:  Kinase
Novelty:  0.00040776
p_int:  0.994691066
p_ni:  0.005251176
p_wrong:  0.000057758
Score:  0.934
Data Source:  BioPlex,STRINGDB
CDK4
Tclin
Family:  Kinase
Novelty:  0.00036742
Score:  0.983
Data Source:  STRINGDB
SKP2
Tbio
Family:  Enzyme
Novelty:  0.00182658
Score:  0.976
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (86)
Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell Cycle
Reactome
Cell Cycle, Mitotic
Reactome
Cyclin D associated events in G1
Reactome
G1 Phase
Reactome
Mitotic G1-G1/S phases
Name
Explore in Pharos
Explore in Source
Cell Cycle
Cell Cycle, Mitotic
Cyclin D associated events in G1
G1 Phase
Mitotic G1-G1/S phases
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
22
8
6
1.3
99.6
HbA1c measurement
3
4
4
95.8
body mass index
3
3
4
94.3
bilirubin measurement
3
2
5
92
body height
3
3
4
91.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
1.3
99.6
HbA1c measurement
4
95.8
body mass index
4
94.3
bilirubin measurement
5
92
body height
4
91.8
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Mouse
MGI:104564
12577
Rat
RGD:727892
246060
Cow
cyclin dependent kinase inhibitor 1C
VGNC:27144
510972
Xenopus
cyclin-dependent kinase inhibitor xic1
XB-GENE-1032978
100126686
Species
Name
OMA
EggNOG
Inparanoid
Mouse
Rat
Cow
cyclin dependent kinase inhibitor 1C
Xenopus
cyclin-dependent kinase inhibitor xic1
Publication Statistics
PubMed Score 509.20
PubMed score by year
PubTator Score 512.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title