Tbio CDKN1C Cyclin-dependent kinase inhibitor 1C

Protein Summary

Description

Potent tight-binding inhibitor of several G1 cyclin/CDK complexes (cyclin E-CDK2, cyclin D2-CDK4, and cyclin A-CDK2) and, to lesser extent, of the mitotic cyclin B-CDC2. Negative regulator of cell proliferation. May play a role in maintenance of the non-proliferative state throughout life. This gene is imprinted, with preferential expression of the maternal allele. The encoded protein is a tight-binding, strong inhibitor of several G1 cyclin/Cdk complexes and a negative regulator of cell proliferation. Mutations in this gene are implicated in sporadic cancers and Beckwith-Wiedemann syndorome, suggesting that this gene is a tumor suppressor candidate. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2010]

Uniprot Accession IDs

• P49918

Gene Name

• CDKN1C

Ensembl ID

• ENST00000414822
• ENSP00000413720
• ENSG00000129757
• ENST00000430149
• ENSP00000411552
• ENST00000440480
• ENSP00000411257

Symbol

• KIP2
• BWS
• WBS
• p57
• BWCR
• KIP2
• p57Kip2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
small molecule perturbation	0.94
biological process	0.91
transcription factor perturbation	0.91
biological term	0.74

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 509.2   (req: < 5)

Gene RIFs: 153   (req: <= 3)

Antibodies: 1047   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 509.2   (req: >= 5)

Gene RIFs: 153   (req: > 3)

Antibodies: 1047   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Protein Sequence and Structure

Residue Counts

Protein Sequence

Find Targets by Sequence

Show Full Sequence

ProtVista Viewer

Expression Data (0 Tissues)

tutorial

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

Go To Tool

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

Approved Drugs (0)

No approved drugs found

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (127)

Explore Interacting Targets

1 – 10 of 127

• See Interactions on String-DB

CCND3

Tchem

Novelty:  0.00223085

p_int:  0.999999713

p_ni:  2.27e-7

p_wrong:  6e-8

Score:  0.991

Data Source:  BioPlex,STRINGDB

CCND1

Tchem

Novelty:  0.0001186

p_int:  0.999999617

p_ni:  3.82e-7

p_wrong:  1e-9

Score:  0.992

Data Source:  BioPlex,STRINGDB

CDK2

Tchem

Family:  Kinase

Novelty:  0.00032118

p_int:  0.99998806

p_ni:  8.74e-7

p_wrong:  0.000011066

Score:  0.995

Data Source:  BioPlex,STRINGDB

CCNA2

Tchem

Novelty:  0.00049887

p_int:  0.999876072

p_ni:  0.000123865

p_wrong:  6.3e-8

Score:  0.987

Data Source:  BioPlex,STRINGDB

CDK3

Tchem

Family:  Kinase

Novelty:  0.03380289

p_int:  0.999846029

p_ni:  0.000153691

p_wrong:  2.8e-7

Score:  0.753

Data Source:  BioPlex,STRINGDB

CCND2

Tbio

Novelty:  0.00157305

p_int:  0.999835629

p_ni:  0.000001221

p_wrong:  0.000163151

Score:  0.986

Data Source:  BioPlex,STRINGDB

CDK6

Tclin

Family:  Kinase

Novelty:  0.00109319

p_int:  0.999318414

p_ni:  0.0006517

p_wrong:  0.000029886

Score:  0.989

Data Source:  BioPlex,STRINGDB

CDK1

Tchem

Family:  Kinase

Novelty:  0.00040776

p_int:  0.994691066

p_ni:  0.005251176

p_wrong:  0.000057758

Score:  0.934

Data Source:  BioPlex,STRINGDB

CDK4

Tclin

Family:  Kinase

Novelty:  0.00036742

Score:  0.983

Data Source:  STRINGDB

SKP2

Tbio

Family:  Enzyme

Novelty:  0.00182658

Score:  0.976

Data Source:  STRINGDB

Nearest Tclin Targets

Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.

Pathways (86)

Reactome (5)

KEGG (1)

PathwayCommons (2)

WikiPathways (78)

Cell Cycle (R-HSA-1640170)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 5 of 5

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell Cycle	597 targets	R-HSA-1640170
Reactome	Cell Cycle, Mitotic	495 targets	R-HSA-69278
Reactome	Cyclin D associated events in G1	45 targets	R-HSA-69231
Reactome	G1 Phase	45 targets	R-HSA-69236
Reactome	Mitotic G1-G1/S phases	151 targets	R-HSA-453279

Name	Explore in Pharos	Explore in Source
Cell Cycle	597 targets	R-HSA-1640170
Cell Cycle, Mitotic	495 targets	R-HSA-69278
Cyclin D associated events in G1	45 targets	R-HSA-69231
G1 Phase	45 targets	R-HSA-69236
Mitotic G1-G1/S phases	151 targets	R-HSA-453279

Viral Interactions (0)

No viral interactions found

Gene Ontology Terms (28)

Functions (3)

Components (2)

Processes (23)

Find Similar Targets

Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
protein-containing complex binding	Inferred from Physical Interaction (IPI)	CAFA
protein kinase inhibitor activity	Inferred from Mutant Phenotype (IMP)	CAFA
cyclin-dependent protein serine/threonine kinase inhibitor activity	Inferred from Electronic Annotation (IEA)	InterPro

Disease Associations ()

No disease associations found

GWAS Traits (28)

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 28

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	22	8	6	1.3	99.6
HbA1c measurement	EFO_0004541	3	4	4		95.8
body mass index	EFO_0004340	3	3	4		94.3
bilirubin measurement	EFO_0004570	3	2	5		92
body height	EFO_0004339	3	3	4		91.8

• Explore on Target Illumination GWAS Analytics (TIGA)

Items per page:

5

1 – 5 of 28

GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
type II diabetes mellitus	EFO_0001360	6	1.3	99.6
HbA1c measurement	EFO_0004541	4		95.8
body mass index	EFO_0004340	4		94.3
bilirubin measurement	EFO_0004570	5		92
body height	EFO_0004339	4		91.8

Reset Zoom  Beta Count   Odds Ratio

Find similar targets by:

UniProt Keyword Find Similar Targets

No Header	No Header
Alternative splicing
Cell cycle
Complete proteome
Disease mutation
Methylation
Nucleus
Phosphoprotein
Protein kinase inhibitor
Reference proteome
Repeat

GWAS Trait Find Similar Targets

No Header	No Header
apolipoprotein A 1 measurement
bilirubin measurement
birth weight
BMI-adjusted hip circumference
BMI-adjusted waist circumference
body height
body mass index
calcium measurement
creatinine measurement
Drugs used in diabetes use measurement

MGI Phenotype Find Similar Targets

No Header	No Header
adipose tissue phenotype
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
digestive/alimentary phenotype
embryo phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
hematopoietic system phenotype

IDG Resources

No IDG generated resources found

Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Mouse	cyclin-dependent kinase inhibitor 1C (P57)	MGI:104564	12577
Rat	cyclin-dependent kinase inhibitor 1C	RGD:727892	246060
Cow	cyclin dependent kinase inhibitor 1C	VGNC:27144	510972
Xenopus	cyclin-dependent kinase inhibitor xic1	XB-GENE-1032978	100126686

Species	Name	OMA	EggNOG	Inparanoid
Mouse	cyclin-dependent kinase inhibitor 1C (P57)
Rat	cyclin-dependent kinase inhibitor 1C
Cow	cyclin dependent kinase inhibitor 1C
Xenopus	cyclin-dependent kinase inhibitor xic1

Publication Statistics

PubMed Score 509.20

PubMed score by year

Reset Zoom

PubTator Score 512.69

PubTator score by year

Reset Zoom

Related Publications

Text Mined References (180)

GeneRif Annotations (153)

Items per page:

10

0 of 0

PMID	Year	Title