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Tbio
LIG4
DNA ligase 4

Protein Summary
Description
Efficiently joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The LIG4-XRCC4 complex is responsible for the NHEJ ligation step, and XRCC4 enhances the joining activity of LIG4. Binding of the LIG4-XRCC4 complex to DNA ends is dependent on the assembly of the DNA-dependent protein kinase complex DNA-PK to these DNA ends. The protein encoded by this gene is a DNA ligase that joins single-strand breaks in a double-stranded polydeoxynucleotide in an ATP-dependent reaction. This protein is essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). This protein forms a complex with the X-ray repair cross complementing protein 4 (XRCC4), and further interacts with the DNA-dependent protein kinase (DNA-PK). Both XRCC4 and DNA-PK are known to be required for NHEJ. The crystal s ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000356922
  • ENSP00000349393
  • ENSG00000174405
  • ENST00000405925
  • ENSP00000385955
  • ENST00000442234
  • ENSP00000402030
  • ENST00000611712
  • ENSP00000484288

Symbol
  • LIG4S
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
biological process
0.96
molecular function
0.95
transcription factor binding site profile
0.84
cellular component
0.8


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.27   (req: < 5)
Gene RIFs: 83   (req: <= 3)
Antibodies: 275   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 237.27   (req: >= 5)
Gene RIFs: 83   (req: > 3)
Antibodies: 275   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 40
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
1
1
85.5
myeloid white cell count
2
2
2
84.7
monocyte percentage of leukocytes
1
1
1
76.1
tonsillectomy risk measurement
1
1
0
1.3
68.8
platelet crit
2
1
2
67.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
1
85.5
myeloid white cell count
2
84.7
monocyte percentage of leukocytes
1
76.1
tonsillectomy risk measurement
0
1.3
68.8
platelet crit
2
67.3
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA ligase 4
VGNC:10471
452653
Macaque
DNA ligase 4
695475
Mouse
MGI:1335098
319583
Rat
RGD:1304639
290907
Dog
DNA ligase 4
VGNC:42675
485544
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA ligase 4
Macaque
DNA ligase 4
Mouse
Rat
Dog
DNA ligase 4
Protein Structure (11 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49917-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (12)
2-LTR circle formation (R-HSA-164843)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
2-LTR circle formation
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Disease
Reactome
Early Phase of HIV Life Cycle
Name
Explore in Pharos
Explore in Source
2-LTR circle formation
DNA Double-Strand Break Repair
DNA Repair
Disease
Early Phase of HIV Life Cycle
Gene Ontology Terms (48)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (245)
1 – 10 of 245
XRCC4
Tbio
Novelty:  0.00305644
p_int:  1
Score:  0.999
Data Source:  BioPlex,Reactome,STRINGDB
APLF
Tbio
Novelty:  0.01347476
p_int:  0.999849717
p_ni:  0.000124037
p_wrong:  0.000026246
Score:  0.989
Data Source:  BioPlex,STRINGDB
ATM
Tchem
Family:  Kinase
Novelty:  0.00019169
Score:  0.998
Data Source:  STRINGDB
XRCC6
Tbio
Novelty:  0.00127955
Score:  0.995
Data Source:  Reactome,STRINGDB
XRCC5
Tbio
Novelty:  0.00150735
Score:  0.994
Data Source:  Reactome,STRINGDB
PRKDC
Tchem
Family:  Kinase
Novelty:  0.00107984
Score:  0.992
Data Source:  Reactome,STRINGDB
NHEJ1
Tbio
Novelty:  0.00773499
Score:  0.985
Data Source:  Reactome,STRINGDB
DCLRE1C
Tbio
Novelty:  0.01064408
Score:  0.984
Data Source:  Reactome,STRINGDB
ERCC1
Tbio
Novelty:  0.00079472
Score:  0.983
Data Source:  STRINGDB
PNKP
Tchem
Family:  Enzyme
Novelty:  0.01038571
Score:  0.978
Data Source:  STRINGDB
Publication Statistics
PubMed Score  237.27

PubMed score by year
PubTator Score  279.41

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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