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Tbio
LIG3
DNA ligase 3

Protein Summary
Description
Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262327
  • ENSP00000262327
  • ENSG00000005156
  • ENST00000378526
  • ENSP00000367787

Symbol
  • LIG2
  • LIG3alpha
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug perturbation
0.99
protein domain
0.97
molecular function
0.96
transcription factor perturbation
0.94
kinase perturbation
0.93


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.81   (req: < 5)
Gene RIFs: 36   (req: <= 3)
Antibodies: 313   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 98.81   (req: >= 5)
Gene RIFs: 36   (req: > 3)
Antibodies: 313   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (194)
POLB
Tchem
Family:  Enzyme
Novelty:  0.00145102
p_int:  0.999999993
p_ni:  6e-9
p_wrong:  1e-9
Score:  0.989
Data Source:  BioPlex,Reactome,STRINGDB
APLF
Tbio
Novelty:  0.01347476
p_int:  0.999999909
p_ni:  9.1e-8
Score:  0.766
Data Source:  BioPlex,STRINGDB
CALML3
Tbio
Novelty:  0.0336689
p_int:  0.99980266
p_ni:  0.00019734
Data Source:  BioPlex
JMJD4
Tbio
Novelty:  0.09951585
p_int:  0.999785071
p_ni:  0.000214928
p_wrong:  1e-9
Data Source:  BioPlex
HIST1H2BA
Tbio
Novelty:  0.02431803
p_int:  0.999545992
p_ni:  0.000454008
Score:  0.162
Data Source:  BioPlex,STRINGDB
H2AFX
Tbio
Novelty:  0.00048694
p_int:  0.999460209
p_ni:  0.000539791
Score:  0.498
Data Source:  BioPlex,STRINGDB
RNF146
Tbio
Family:  Enzyme
Novelty:  0.05463359
p_int:  0.998491396
p_ni:  0.001508604
Score:  0.356
Data Source:  BioPlex,STRINGDB
XRCC6
Tbio
Novelty:  0.00127955
p_int:  0.998437614
p_ni:  0.001562386
Score:  0.951
Data Source:  BioPlex,STRINGDB
RPA2
Tbio
Novelty:  0.00879115
p_int:  0.997587246
p_ni:  0.002412753
p_wrong:  1e-9
Score:  0.946
Data Source:  BioPlex,Reactome,STRINGDB
FMC1
Tbio
Novelty:  0.06702205
p_int:  0.996180801
p_ni:  0.001664718
p_wrong:  0.002154482
Score:  0.224
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (14)
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway (R-HSA-5649702)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Reactome
Base Excision Repair
Reactome
DNA Double-Strand Break Repair
Reactome
DNA Repair
Reactome
Gap-filling DNA repair synthesis and ligation in GG-NER
Name
Explore in Pharos
Explore in Source
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway
Base Excision Repair
DNA Double-Strand Break Repair
DNA Repair
Gap-filling DNA repair synthesis and ligation in GG-NER
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
2
1
0
1.2
80
educational attainment
1
1
1
61.9
pulse pressure measurement
1
1
1
53.5
electrocardiography
1
1
17
44.7
macrophage inflammatory protein 1b measurement
1
1
1
37.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
QT interval
0
1.2
80
educational attainment
1
61.9
pulse pressure measurement
1
53.5
electrocardiography
17
44.7
macrophage inflammatory protein 1b measurement
1
37.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
DNA ligase 3
VGNC:9437
454581
Macaque
DNA ligase 3
715181
Mouse
MGI:109152
16882
Rat
RGD:1309875
303369
Dog
DNA ligase 3
VGNC:42674
491145
Species
Name
OMA
EggNOG
Inparanoid
Chimp
DNA ligase 3
Macaque
DNA ligase 3
Mouse
Rat
Dog
DNA ligase 3
Publication Statistics
PubMed Score 98.81
PubMed score by year
PubTator Score 82.53
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title