Protein Summary
Isoform 3 functions as heterodimer with DNA-repair protein XRCC1 in the nucleus and can correct defective DNA strand-break repair and sister chromatid exchange following treatment with ionizing radiation and alkylating agents. Isoform 1 is targeted to mitochondria, where it functions as DNA ligase in mitochondrial base-excision DNA repair (PubMed:10207110, PubMed:24674627). This gene is a member of the DNA ligase family. Each member of this family encodes a protein that catalyzes the joining of DNA ends but they each have a distinct role in DNA metabolism. The protein encoded by this gene is involved in excision repair and is located in both the mitochondria and nucleus, with translation initiation from the upstream start codon allowing for transport to the mitochondria and translation initiation from a downstream start codon allowing for transport to the nucleus. Additionally, alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by ...more
- ENST00000262327
- ENSP00000262327
- ENSG00000005156
- ENST00000378526
- ENSP00000367787
- LIG2
- LIG3alpha
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug perturbation | 0.99 | ||
protein domain | 0.97 | ||
molecular function | 0.96 | ||
transcription factor perturbation | 0.94 | ||
kinase perturbation | 0.93 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 98.81 (req: < 5)
Gene RIFs: 36 (req: <= 3)
Antibodies: 313 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 98.81 (req: >= 5)
Gene RIFs: 36 (req: > 3)
Antibodies: 313 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 19
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (194)
POLB
Family: Enzyme
Novelty: 0.00145102
p_int: 0.999999993
p_ni: 6e-9
p_wrong: 1e-9
Score: 0.989
Data Source: BioPlex,Reactome,STRINGDB
APLF
Novelty: 0.01347476
p_int: 0.999999909
p_ni: 9.1e-8
Score: 0.766
Data Source: BioPlex,STRINGDB
JMJD4
Novelty: 0.09951585
p_int: 0.999785071
p_ni: 0.000214928
p_wrong: 1e-9
Data Source: BioPlex
HIST1H2BA
Novelty: 0.02431803
p_int: 0.999545992
p_ni: 0.000454008
Score: 0.162
Data Source: BioPlex,STRINGDB
H2AFX
Novelty: 0.00048694
p_int: 0.999460209
p_ni: 0.000539791
Score: 0.498
Data Source: BioPlex,STRINGDB
RNF146
Family: Enzyme
Novelty: 0.05463359
p_int: 0.998491396
p_ni: 0.001508604
Score: 0.356
Data Source: BioPlex,STRINGDB
XRCC6
Novelty: 0.00127955
p_int: 0.998437614
p_ni: 0.001562386
Score: 0.951
Data Source: BioPlex,STRINGDB
RPA2
Novelty: 0.00879115
p_int: 0.997587246
p_ni: 0.002412753
p_wrong: 1e-9
Score: 0.946
Data Source: BioPlex,Reactome,STRINGDB
FMC1
Novelty: 0.06702205
p_int: 0.996180801
p_ni: 0.001664718
p_wrong: 0.002154482
Score: 0.224
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (14)
Reactome (13)
KEGG (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway | ||||
Reactome | Base Excision Repair | ||||
Reactome | DNA Double-Strand Break Repair | ||||
Reactome | DNA Repair | ||||
Reactome | Gap-filling DNA repair synthesis and ligation in GG-NER | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway | ||||
Base Excision Repair | ||||
DNA Double-Strand Break Repair | ||||
DNA Repair | ||||
Gap-filling DNA repair synthesis and ligation in GG-NER | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (5)
Components (5)
Processes (14)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations (null)
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
QT interval | 2 | 1 | 0 | 1.2 | 80 | ||||
educational attainment | 1 | 1 | 1 | 61.9 | |||||
pulse pressure measurement | 1 | 1 | 1 | 53.5 | |||||
electrocardiography | 1 | 1 | 17 | 44.7 | |||||
macrophage inflammatory protein 1b measurement | 1 | 1 | 1 | 37.7 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
QT interval | 0 | 1.2 | 80 | ||||
educational attainment | 1 | 61.9 | |||||
pulse pressure measurement | 1 | 53.5 | |||||
electrocardiography | 17 | 44.7 | |||||
macrophage inflammatory protein 1b measurement | 1 | 37.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | DNA ligase 3 | VGNC:9437 | 454581 | |||||
Macaque | DNA ligase 3 | 715181 | ||||||
Mouse | MGI:109152 | 16882 | ||||||
Rat | RGD:1309875 | 303369 | ||||||
Dog | DNA ligase 3 | VGNC:42674 | 491145 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | DNA ligase 3 | |||||
Macaque | DNA ligase 3 | |||||
Mouse | ||||||
Rat | ||||||
Dog | DNA ligase 3 | |||||
Publication Statistics
PubMed Score 98.81
PubMed score by year
PubTator Score 82.53
PubTator score by year
Related Publications
Text Mined References (82)
GeneRif Annotations (36)
Items per page:
0 of 0
PMID | Year | Title |
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