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Tbio
GMPS
GMP synthase [glutamine-hydrolyzing]

Protein Summary
Description
Involved in the de novo synthesis of guanine nucleotides which are not only essential for DNA and RNA synthesis, but also provide GTP, which is involved in a number of cellular processes important for cell division. In the de novo synthesis of purine nucleotides, IMP is the branch point metabolite at which point the pathway diverges to the synthesis of either guanine or adenine nucleotides. In the guanine nucleotide pathway, there are 2 enzymes involved in converting IMP to GMP, namely IMP dehydrogenase (IMPD1), which catalyzes the oxidation of IMP to XMP, and GMP synthetase, which catalyzes the amination of XMP to GMP. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000295920
  • ENSP00000295920
  • ENSG00000163655
  • ENST00000496455
  • ENSP00000419851

Symbol
  • GATD7
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
1
molecular function
0.96
protein domain
0.92
transcription factor perturbation
0.84
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.17   (req: < 5)
Gene RIFs: 5   (req: <= 3)
Antibodies: 239   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 157.17   (req: >= 5)
Gene RIFs: 5   (req: > 3)
Antibodies: 239   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
1
1
71
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
71
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
guanine monophosphate synthase
VGNC:1827
460797
Macaque
guanine monophosphate synthase
706932
Mouse
MGI:2448526
229363
Rat
RGD:1310063
295088
Dog
guanine monophosphate synthase
VGNC:41296
477123
Species
Name
OMA
EggNOG
Inparanoid
Chimp
guanine monophosphate synthase
Macaque
guanine monophosphate synthase
Mouse
Rat
Dog
guanine monophosphate synthase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49915-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase biosynthesis
Reactome
Purine ribonucleoside monophosphate biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase biosynthesis
Purine ribonucleoside monophosphate biosynthesis
Protein-Protein Interactions (415)
1 – 10 of 415
GTF2E2
Tbio
Novelty: 0.18033153
p_int: 0.846422924
p_ni: 0.153577076
Score: 0.301
Data Source: BioPlex,STRINGDB
IMPDH1
Tclin
Family: Enzyme
Novelty: 0.00758575
Score: 0.998
Data Source: STRINGDB
IMPDH2
Tclin
Family: Enzyme
Novelty: 0.00815361
Score: 0.995
Data Source: STRINGDB
GMPR
Tbio
Family: Enzyme
Novelty: 0.03505649
Score: 0.992
Data Source: STRINGDB
CTPS1
Tbio
Family: Enzyme
Novelty: 0.00911596
Score: 0.992
Data Source: STRINGDB
APRT
Tbio
Family: Enzyme
Novelty: 0.00483077
Score: 0.989
Data Source: STRINGDB
GMPR2
Tbio
Family: Enzyme
Novelty: 0.16707153
Score: 0.986
Data Source: STRINGDB
HPRT1
Tchem
Family: Enzyme
Novelty: 0.00032232
Score: 0.977
Data Source: STRINGDB
PFAS
Tbio
Family: Enzyme
Novelty: 0.00252212
Score: 0.963
Data Source: STRINGDB
ITPA
Tbio
Family: Enzyme
Novelty: 0.00235169
Score: 0.96
Data Source: STRINGDB
Publication Statistics
PubMed Score  157.17

PubMed score by year
PubTator Score  77.15

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer