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Tbio
CAMP
Cathelicidin antimicrobial peptide

Protein Summary
Description
Binds to bacterial lipopolysaccharides (LPS), has antibacterial activity. This gene encodes a member of an antimicrobial peptide family, characterized by a highly conserved N-terminal signal peptide containing a cathelin domain and a structurally variable cationic antimicrobial peptide, which is produced by extracellular proteolysis from the C-terminus. In addition to its antibacterial, antifungal, and antiviral activities, the encoded protein functions in cell chemotaxis, immune mediator induction, and inflammatory response regulation. [provided by RefSeq, Sep 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000576243
  • ENSP00000458149
  • ENSG00000164047

Symbol
  • CAP18
  • FALL39
  • LL37
  • CAP18
  • CRAMP
  • HSD26
  • CAP-18
  • FALL39
  • FALL-39
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.99
biological process
0.82
disease
0.78
cellular component
0.7
gene perturbation
0.67


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1816.09   (req: < 5)
Gene RIFs: 262   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1816.09   (req: >= 5)
Gene RIFs: 262   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cathelicidin antimicrobial peptide
VGNC:1751
741881
Macaque
cathelicidin antimicrobial peptide
619186
Mouse
MGI:108443
12796
Rat
RGD:1559878
316010
Dog
cathelicidin antimicrobial peptide
VGNC:38688
442947
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cathelicidin antimicrobial peptide
Macaque
cathelicidin antimicrobial peptide
Mouse
Rat
Dog
cathelicidin antimicrobial peptide
Protein Structure (15 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49913-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 15
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (11)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Neutrophil degranulation
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Immune System
Innate Immune System
Neutrophil degranulation
Gene Ontology Terms (25)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (214)
1 – 10 of 214
ELANE
Tclin
Family: Enzyme
Novelty: 0.00026112
Score: 0.98
Data Source: STRINGDB
DEFA4
Tbio
Novelty: 0.04566082
Score: 0.98
Data Source: STRINGDB
PRTN3
Tchem
Family: Enzyme
Novelty: 0.00022728
Score: 0.978
Data Source: STRINGDB
BPI
Tbio
Novelty: 0.00229665
Score: 0.974
Data Source: STRINGDB
PGLYRP1
Tbio
Novelty: 0.00231527
Score: 0.968
Data Source: STRINGDB
SLPI
Tbio
Family: Enzyme
Novelty: 0.00194459
Score: 0.964
Data Source: STRINGDB
LCN2
Tbio
Family: Enzyme
Novelty: 0.00034678
Score: 0.958
Data Source: STRINGDB
HBB
Tbio
Novelty: 0.00049683
Score: 0.955
Data Source: STRINGDB
LTF
Tbio
Novelty: 0.00114254
Score: 0.946
Data Source: STRINGDB
CXCL1
Tbio
Novelty: 0.00059123
Score: 0.941
Data Source: STRINGDB
Publication Statistics
PubMed Score  1816.09

PubMed score by year
PubTator Score  1720.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer