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Tclin
DIO1
Type I iodothyronine deiodinase

Protein Summary
Description
Responsible for the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine) and of T3 into T2 (3,3'-diiodothyronine). Plays a role in providing a source of plasma T3 by deiodination of T4 in peripheral tissues such as liver and kidney. The protein encoded by this gene belongs to the iodothyronine deiodinase family. It catalyzes the activation, as well as the inactivation of thyroid hormone by outer and inner ring deiodination, respectively. The activation reaction involves the conversion of the prohormone thyroxine (3,5,3',5'-tetraiodothyronine, T4), secreted by the thyroid gland, to the bioactive thyroid hormone (3,5,3'-triiodothyronine, T3) by 5'-deiodination. This protein provides most of the circulating T3, which is essential for growth, differentiation and basal metabolism in vertebrates. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals transl ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322679
  • ENSP00000323198
  • ENSG00000211452
  • ENST00000361921
  • ENSP00000354643
  • ENST00000388876
  • ENSP00000373528
  • ENST00000525202
  • ENSP00000435725
  • ENST00000532493
  • ENSP00000434758

Symbol
  • ITDI1
  • TXDI1
  • 5DI
  • TXDI1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.77
interacting protein
0.76
protein domain
0.58
chemical
0.57
disease
0.57


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
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GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.11   (req: < 5)
Gene RIFs: 38   (req: <= 3)
Antibodies: 107   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 93.11   (req: >= 5)
Gene RIFs: 38   (req: > 3)
Antibodies: 107   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 5
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
propylthiouracil
Rendered image for propylthiouracil
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroxine measurement
1
1
1
81.1
hormone measurement
1
1
3
80.4
gut microbiome measurement
1
1
0
3.6
24.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
thyroxine measurement
1
81.1
hormone measurement
3
80.4
gut microbiome measurement
0
3.6
24.5
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
iodothyronine deiodinase 1
VGNC:9991
469331
Mouse
MGI:94896
13370
Rat
RGD:2504
25430
Pig
iodothyronine deiodinase 1
414380
Opossum
iodothyronine deiodinase 1 [Source:HGNC Symbol;Acc:HGNC:2883]
Species
Name
OMA
EggNOG
Inparanoid
Chimp
iodothyronine deiodinase 1
Mouse
Rat
Pig
iodothyronine deiodinase 1
Opossum
iodothyronine deiodinase 1 [Source:HGNC Symbol;Acc:HGNC:2883]
Pathways (8)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of amine-derived hormones
Reactome
Metabolism of amino acids and derivatives
Reactome
Regulation of thyroid hormone activity
Reactome
Thyroxine biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of amine-derived hormones
Metabolism of amino acids and derivatives
Regulation of thyroid hormone activity
Thyroxine biosynthesis
Gene Ontology Terms (8)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (54)
1 – 10 of 54
UGT2B10
Tbio
Family:  Enzyme
Novelty:  0.03135595
Score:  0.913
Data Source:  STRINGDB
DIO3
Tbio
Family:  Enzyme
Novelty:  0.0047888
Score:  0.911
Data Source:  STRINGDB
UGT2B11
Tbio
Family:  Enzyme
Novelty:  0.13396162
Score:  0.907
Data Source:  STRINGDB
SULT1A1
Tchem
Family:  Enzyme
Novelty:  0.00238409
Score:  0.906
Data Source:  STRINGDB
SULT1A2
Tbio
Family:  Enzyme
Novelty:  0.01102416
Score:  0.902
Data Source:  STRINGDB
SEPHS1
Tbio
Family:  Enzyme
Novelty:  0.01539662
Score:  0.804
Data Source:  STRINGDB
SEPHS2
Tdark
Family:  Enzyme
Novelty:  0.01657572
Score:  0.804
Data Source:  STRINGDB
GPBAR1
Tchem
Family:  GPCR
Novelty:  0.00290465
Score:  0.715
Data Source:  STRINGDB
ALKAL2
Tbio
Novelty:  0.12969286
Score:  0.712
Data Source:  STRINGDB
ALKAL1
Tbio
Novelty:  0.12828794
Score:  0.712
Data Source:  STRINGDB
Publication Statistics
PubMed Score  93.11

PubMed score by year
PubTator Score  76.87

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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