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Tbio
GZMK
Granzyme K

Protein Summary
Description
This gene product is a member of a group of related serine proteases from the cytoplasmic granules of cytotoxic lymphocytes. Cytolytic T lymphocytes (CTL) and natural killer (NK) cells share the remarkable ability to recognize, bind, and lyse specific target cells. They are thought to protect their host by lysing cells bearing on their surface 'nonself' antigens, usually peptides or proteins resulting from infection by intracellular pathogens. The protein described here lacks consensus sequences for N-glycosylation present in other granzymes. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000231009
  • ENSP00000231009
  • ENSG00000113088

Symbol
  • TRYP2
  • TRYP2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.89
tissue sample
0.79
tissue
0.68
protein domain
0.58
gene perturbation
0.53


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.96   (req: < 5)
Gene RIFs: 13   (req: <= 3)
Antibodies: 261   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 70.96   (req: >= 5)
Gene RIFs: 13   (req: > 3)
Antibodies: 261   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
endothelial cell-specific molecule 1 measurement
1
1
1
55.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
endothelial cell-specific molecule 1 measurement
1
55.3
Protein Data Bank (2)
1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Protein-Protein Interactions (49)
1 – 10 of 49
GZMA
Tbio
Family: Enzyme
Novelty: 0.00322362
Score: 0.916
Data Source: STRINGDB
CD2
Tclin
Novelty: 0.00037283
Score: 0.859
Data Source: STRINGDB
KLRB1
Tbio
Novelty: 0.00299998
Score: 0.783
Data Source: STRINGDB
CD8A
Tbio
Novelty: 0.00002519
Score: 0.774
Data Source: STRINGDB
PRF1
Tchem
Novelty: 0.0002835
Score: 0.742
Data Source: STRINGDB
CXCR6
Tbio
Family: GPCR
Novelty: 0.00602345
Score: 0.742
Data Source: STRINGDB
GZMH
Tbio
Family: Enzyme
Novelty: 0.01480634
Score: 0.732
Data Source: STRINGDB
NKG7
Tdark
Novelty: 0.0599879
Score: 0.715
Data Source: STRINGDB
CCR5
Tclin
Family: GPCR
Novelty: 0.00022549
Score: 0.696
Data Source: STRINGDB
MSMB
Tbio
Novelty: 0.00241546
Score: 0.671
Data Source: STRINGDB
Publication Statistics
PubMed Score  70.96

PubMed score by year
PubTator Score  32.16

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer