Tchem KLK7 Kallikrein-7

Protein Classes

PANTHER Classes

Protein / ... / Serine Protease / Kallikrein-7

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Kallikrein-7

Protein Summary

Description

May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011]

Uniprot Accession IDs

• P49862
• A8K0U5
• Q8N5N9
• Q8NFV7
• hK7

Gene Name

• KLK7

Ensembl ID

• ENST00000391807
• ENSP00000375683
• ENSG00000169035
• ENST00000595820
• ENSP00000470538
• ENST00000597707
• ENSP00000469950

Symbol

• PRSS6
• SCCE
• hK7
• SCCE
• PRSS6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.98
virus perturbation	0.64
biological term	0.62
PubMedID	0.59
protein domain	0.58

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.51   (req: < 5)

Gene RIFs: 54   (req: <= 3)

Antibodies: 382   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.51   (req: >= 5)

Gene RIFs: 54   (req: > 3)

Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (26)

Explore Active Ligands

1 – 10 of 26

SID14731064

KLK7Tchem Enzyme

IC50 : 7.4000001

compound 4d [PMID: 25489658]

KLK7Tchem Enzyme

IC50 : 7.19000006

CHEMBL1580091

KLK7Tchem Enzyme

IC50 : 6.18

CHEMBL4575974

KLK7Tchem Enzyme

IC50 : 7.32

SID24823247

KLK7Tchem Enzyme

IC50 : 6.66

CHEMBL4061897

KLK7Tchem Enzyme

Ki : 7.16

CHEMBL4081142

KLK7Tchem Enzyme

Ki : 6.89

CHEMBL1580446

KLK7Tchem Enzyme

IC50 : 6.21

CHEMBL4092637

KLK7Tchem Enzyme

Ki : 6.13

CHEMBL4228441

KLK7Tchem Enzyme

IC50 : 7.32

GWAS Traits (5)

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5

1 – 5 of 5

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
vitamin D measurement	EFO_0004631	5	3	5		91.6
blood protein measurement	EFO_0007937	1	2	2		89.8
kallikrein‐6 measurement	EFO_0010622	1	1	1		87.2
prostate specific antigen measurement	EFO_0004624	1	1	1		72.3
kallikrein-11 measurement	EFO_0010573	1	1	0	1.5	69.5

• Explore on Target Illumination GWAS Analytics (TIGA)

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5

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
vitamin D measurement	EFO_0004631	5		91.6
blood protein measurement	EFO_0007937	2		89.8
kallikrein‐6 measurement	EFO_0010622	1		87.2
prostate specific antigen measurement	EFO_0004624	1		72.3
kallikrein-11 measurement	EFO_0010573	0	1.5	69.5

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Orthologs (4)

1 – 4 of 4

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Macaque	kallikrein related peptidase 7		722683
Mouse	kallikrein related-peptidase 7 (chymotryptic, stratum corneum)	MGI:1346336	23993
Cow	kallikrein related peptidase 7	VGNC:30681	506380
Opossum	kallikrein-7		100012470

Species	Name	OMA	EggNOG	Inparanoid
Macaque	kallikrein related peptidase 7
Mouse	kallikrein related-peptidase 7 (chymotryptic, stratum corneum)
Cow	kallikrein related peptidase 7
Opossum	kallikrein-7

Protein Structure (8 Structures, 1 AlphaFold Model)

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Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49862-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (28)

Reactome (2)

WikiPathways (26)

Degradation of the extracellular matrix (R-HSA-1474228)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244

Name	Explore in Pharos	Explore in Source
Degradation of the extracellular matrix	111 targets	R-HSA-1474228
Extracellular matrix organization	297 targets	R-HSA-1474244

Gene Ontology Terms (11)

Functions (4)

Components (4)

Processes (3)

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Items per page:

10

1 – 4 of 4

GO Term	Evidence	Assigned by
peptidase activity	Inferred from Mutant Phenotype (IMP)	UniProtKB
metalloendopeptidase activity	Traceable Author Statement (TAS)	Reactome
serine-type peptidase activity	Traceable Author Statement (TAS)	ProtInc
serine-type endopeptidase activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (58)

Explore Interacting Targets

1 – 10 of 58

• See Interactions on String-DB

TBC1D22B

Tbio

Novelty:  0.49852962

p_int:  0.999974421

p_ni:  0.000025579

Data Source:  BioPlex

DTL

Tbio

Novelty:  0.01659105

p_int:  0.999920658

p_ni:  0.000067275

p_wrong:  0.000012067

Data Source:  BioPlex

VAV1

Tchem

Novelty:  0.00180518

p_int:  0.999848797

p_ni:  0.000151012

p_wrong:  1.92e-7

Data Source:  BioPlex

EHBP1

Tbio

Novelty:  0.0656858

p_int:  0.999728527

p_ni:  0.000271471

p_wrong:  2e-9

Data Source:  BioPlex

CA8

Tbio

Family:  Enzyme

Novelty:  0.0041859

p_int:  0.999630101

p_ni:  0.000305039

p_wrong:  0.00006486

Data Source:  BioPlex

GMCL1

Tbio

Novelty:  0.1543762

p_int:  0.999579667

p_ni:  0.000400422

p_wrong:  0.000019911

Data Source:  BioPlex

FTH1

Tbio

Novelty:  0.000863

p_int:  0.999456888

p_ni:  0.000543111

p_wrong:  1e-9

Score:  0.154

Data Source:  BioPlex,STRINGDB

FCF1

Tdark

Novelty:  0.04202976

p_int:  0.999403047

p_ni:  0.000596953

Data Source:  BioPlex

PI4KA

Tchem

Family:  Kinase

Novelty:  0.01701469

p_int:  0.9992729

p_ni:  0.000674867

p_wrong:  0.000052234

Data Source:  BioPlex

VNN2

Tbio

Novelty:  0.02286648

p_int:  0.998348963

p_ni:  0.001639402

p_wrong:  0.000011635

Score:  0.168

Data Source:  BioPlex,STRINGDB

Publication Statistics

PubMed Score  147.51

PubMed score by year

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PubTator Score  115.47

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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Alternative splicing
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Disulfide bond
Glycoprotein
Hydrolase
Protease
Reference proteome
Secreted

GWAS Trait Find Similar Targets

No Header	No Header
blood protein measurement
kallikrein-11 measurement
kallikrein‐6 measurement
prostate specific antigen measurement
vitamin D measurement