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Tchem
KLK7
Kallikrein-7

Protein Summary
Description
May catalyze the degradation of intercellular cohesive structures in the cornified layer of the skin in the continuous shedding of cells from the skin surface. Specific for amino acid residues with aromatic side chains in the P1 position. Cleaves insulin A chain at '14-Tyr-|-Gln-15' and insulin B chain at '6-Leu-|-Cys-7', '16-Tyr-|-Leu-17', '25-Phe-|-Tyr-26' and '26-Tyr-|-Thr-27'. Could play a role in the activation of precursors to inflammatory cytokines. This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000391807
  • ENSP00000375683
  • ENSG00000169035
  • ENST00000595820
  • ENSP00000470538
  • ENST00000597707
  • ENSP00000469950

Symbol
  • PRSS6
  • SCCE
  • hK7
  • SCCE
  • PRSS6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
0.98
virus perturbation
0.64
biological term
0.62
PubMedID
0.59
protein domain
0.58


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.51   (req: < 5)
Gene RIFs: 54   (req: <= 3)
Antibodies: 382   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.51   (req: >= 5)
Gene RIFs: 54   (req: > 3)
Antibodies: 382   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 26
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
3
5
91.6
blood protein measurement
1
2
2
89.8
kallikrein‐6 measurement
1
1
1
87.2
prostate specific antigen measurement
1
1
1
72.3
kallikrein-11 measurement
1
1
0
1.5
69.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
vitamin D measurement
5
91.6
blood protein measurement
2
89.8
kallikrein‐6 measurement
1
87.2
prostate specific antigen measurement
1
72.3
kallikrein-11 measurement
0
1.5
69.5
Orthologs (4)
1 – 4 of 4
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
kallikrein related peptidase 7
722683
Mouse
MGI:1346336
23993
Cow
kallikrein related peptidase 7
VGNC:30681
506380
Opossum
kallikrein-7
100012470
Species
Name
OMA
EggNOG
Inparanoid
Macaque
kallikrein related peptidase 7
Mouse
Cow
kallikrein related peptidase 7
Opossum
kallikrein-7
Protein Structure (8 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49862-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 8
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (28)
Degradation of the extracellular matrix (R-HSA-1474228)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Degradation of the extracellular matrix
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Degradation of the extracellular matrix
Extracellular matrix organization
Protein-Protein Interactions (58)
1 – 10 of 58
TBC1D22B
Tbio
Novelty:  0.49852962
p_int:  0.999974421
p_ni:  0.000025579
Data Source:  BioPlex
DTL
Tbio
Novelty:  0.01659105
p_int:  0.999920658
p_ni:  0.000067275
p_wrong:  0.000012067
Data Source:  BioPlex
VAV1
Tchem
Novelty:  0.00180518
p_int:  0.999848797
p_ni:  0.000151012
p_wrong:  1.92e-7
Data Source:  BioPlex
EHBP1
Tbio
Novelty:  0.0656858
p_int:  0.999728527
p_ni:  0.000271471
p_wrong:  2e-9
Data Source:  BioPlex
CA8
Tbio
Family:  Enzyme
Novelty:  0.0041859
p_int:  0.999630101
p_ni:  0.000305039
p_wrong:  0.00006486
Data Source:  BioPlex
GMCL1
Tbio
Novelty:  0.1543762
p_int:  0.999579667
p_ni:  0.000400422
p_wrong:  0.000019911
Data Source:  BioPlex
FTH1
Tbio
Novelty:  0.000863
p_int:  0.999456888
p_ni:  0.000543111
p_wrong:  1e-9
Score:  0.154
Data Source:  BioPlex,STRINGDB
FCF1
Tdark
Novelty:  0.04202976
p_int:  0.999403047
p_ni:  0.000596953
Data Source:  BioPlex
PI4KA
Tchem
Family:  Kinase
Novelty:  0.01701469
p_int:  0.9992729
p_ni:  0.000674867
p_wrong:  0.000052234
Data Source:  BioPlex
VNN2
Tbio
Novelty:  0.02286648
p_int:  0.998348963
p_ni:  0.001639402
p_wrong:  0.000011635
Score:  0.168
Data Source:  BioPlex,STRINGDB
Publication Statistics
PubMed Score  147.51

PubMed score by year
PubTator Score  115.47

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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