Tbio TAF6 Transcription initiation factor TFIID subunit 6

Protein Summary

Description

TAFs are components of the transcription factor IID (TFIID) complex, PCAF histone acetylase complex and TBP-free TAFII complex (TFTC). TIIFD is multimeric protein complex that plays a central role in mediating promoter responses to various activators and repressors. Isoform 4: Transcriptional regulator which acts primarily as a positive regulator of transcription (PubMed:20096117, PubMed:29358700). Recruited to the promoters of a number of genes including GADD45A and CDKN1A/p21, leading to transcriptional up-regulation and subsequent induction of apoptosis (PubMed:11583621). Also up-regulates expression of other genes including GCNA/ACRC, HES1 and IFFO1 (PubMed:18628956). In contrast, down-regulates transcription of MDM2 (PubMed:11583621). Acts as a transcriptional coactivator to enhance transcription of TP53/p53-responsive genes such as DUSP1 (PubMed:20096117). Can also activate transcription and apoptosis independently of TP53 (PubMed:18628956). Drives apoptosis via the intrinsic apoptotic pathway by up-regulating apoptosis effectors such as BCL2L11/BIM and PMAIP1/NOXA (PubMed:29358700). Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds weakly to TBP but strongly to TAF1, the largest subunit of TFIID. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2010]

Uniprot Accession IDs

• P49848
• A4D2B2
• A4D2B3
• B4DT11
• D6W5U2
• Q6AI29

Gene Name

• TAF6

Ensembl ID

• ENST00000344095
• ENSP00000344537
• ENSG00000106290
• ENST00000437822
• ENSP00000399982
• ENST00000452041
• ENSP00000416396
• ENST00000453269
• ENSP00000389575

Symbol

• TAF2E
• TAFII70
• ALYUS
• TAF2E
• TAFII70
• TAFII80
• TAFII85
• MGC:8964
• TAFII-70
• TAFII-80
• TAF(II)70
• TAF(II)80

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
hub protein	0.96
protein complex	0.94
protein domain	0.73
tissue sample	0.66
virus	0.66

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Transcription Initiation Factor Tfiid Subunit 6

DTO Classes

Protein / Transcription Factor / Transcription Initiation Factor Tfiid Subunit 6

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.07   (req: < 5)

Gene RIFs: 9   (req: <= 3)

Antibodies: 191   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 29.07   (req: >= 5)

Gene RIFs: 9   (req: > 3)

Antibodies: 191   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0