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Tclin
GSK3A
Glycogen synthase kinase-3 alpha

Protein Summary
Description
Constitutively active protein kinase that acts as a negative regulator in the hormonal control of glucose homeostasis, Wnt signaling and regulation of transcription factors and microtubules, by phosphorylating and inactivating glycogen synthase (GYS1 or GYS2), CTNNB1/beta-catenin, APC and AXIN1. Requires primed phosphorylation of the majority of its substrates. Contributes to insulin regulation of glycogen synthesis by phosphorylating and inhibiting GYS1 activity and hence glycogen synthesis. Regulates glycogen metabolism in liver, but not in muscle. May also mediate the development of insulin resistance by regulating activation of transcription factors. In Wnt signaling, regulates the level and transcriptional activity of nuclear CTNNB1/beta-catenin. Facilitates amyloid precursor protein (APP) processing and the generation of APP-derived amyloid plaques found in Alzheimer disease. May be involved in the regulation of replication in pancreatic beta-cells. Is necessary for the establish ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000222330
  • ENSP00000222330
  • ENSG00000105723
  • ENST00000453535
  • ENSP00000412663
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
drug perturbation
1
kinase
0.99
molecular function
0.97
transcription factor binding site profile
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.79   (req: < 5)
Gene RIFs: 81   (req: <= 3)
Antibodies: 1048   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 94.79   (req: >= 5)
Gene RIFs: 81   (req: > 3)
Antibodies: 1048   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 43
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 162
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (5)
ProKinO
Thumbnail image for ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (148)
AXIN1
Tbio
Novelty:  0.00175842
p_int:  1
Score:  0.994
Data Source:  BioPlex,STRINGDB
CRYBG3
Tdark
Family:  Enzyme
Novelty:  0.24063491
p_int:  0.999999997
p_ni:  3e-9
Data Source:  BioPlex
GSK3B
Tclin
Family:  Kinase
Novelty:  0.00095115
p_int:  0.999999851
p_ni:  1.49e-7
Score:  0.907
Data Source:  BioPlex,STRINGDB
PRUNE1
Tchem
Novelty:  0.02136836
p_int:  0.999998145
p_ni:  0.000001855
Score:  0.51
Data Source:  BioPlex,STRINGDB
RCAN1
Tbio
Novelty:  0.0030009
p_int:  0.99999773
p_ni:  7.7e-7
p_wrong:  0.000001501
Score:  0.715
Data Source:  BioPlex,STRINGDB
AXIN2
Tchem
Novelty:  0.00273189
p_int:  0.999997385
p_ni:  0.000002614
p_wrong:  1e-9
Score:  0.989
Data Source:  BioPlex,STRINGDB
TRAK2
Tbio
Novelty:  0.04192075
p_int:  0.999995924
p_ni:  0.000004045
p_wrong:  3.1e-8
Score:  0.167
Data Source:  BioPlex,STRINGDB
SAMHD1
Tbio
Family:  Enzyme
Novelty:  0.00294595
p_int:  0.999974811
p_ni:  0.000025189
Score:  0.221
Data Source:  BioPlex,STRINGDB
PPP1R2
Tbio
Family:  Enzyme
Novelty:  0.02581522
p_int:  0.999967538
p_ni:  0.000032462
Score:  0.516
Data Source:  BioPlex,STRINGDB
FBXO42
Tbio
Novelty:  0.17658866
p_int:  0.999935093
p_ni:  0.000064897
p_wrong:  1e-8
Score:  0.343
Data Source:  BioPlex,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (48)
AKT phosphorylates targets in the cytosol (R-HSA-198323)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AKT phosphorylates targets in the cytosol
Reactome
Constitutive Signaling by AKT1 E17K in Cancer
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
IRE1alpha activates chaperones
Name
Explore in Pharos
Explore in Source
AKT phosphorylates targets in the cytosol
Constitutive Signaling by AKT1 E17K in Cancer
Disease
Diseases of signal transduction
IRE1alpha activates chaperones
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (50)
Find Similar Targets
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Traceable Author Statement (TAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Disease Associations (null)
No disease associations found
GWAS Traits (17)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
1
3
68.9
1
1
1
66.7
blood protein measurement
2
2
2
64.5
leukocyte count
2
2
2
59.3
corneal resistance factor
1
1
1
56.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
monocyte count
3
68.9
1
66.7
blood protein measurement
2
64.5
leukocyte count
2
59.3
corneal resistance factor
1
56.7
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
glycogen synthase kinase 3 alpha
VGNC:11125
456071
Macaque
glycogen synthase kinase-3 alpha [Source:RefSeq peptide;Acc:NP_001253565]
Mouse
MGI:2152453
606496
Rat
RGD:620351
50686
Dog
glycogen synthase kinase 3 alpha
484476
Species
Name
OMA
EggNOG
Inparanoid
Chimp
glycogen synthase kinase 3 alpha
Macaque
glycogen synthase kinase-3 alpha [Source:RefSeq peptide;Acc:NP_001253565]
Mouse
Rat
Dog
glycogen synthase kinase 3 alpha
Publication Statistics
PubMed Score 94.79
PubMed score by year
PubTator Score 184.06
PubTator score by year
Patents
Patents by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title