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Tclin
NDUFV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

Protein Summary
Description
Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). The mitochondrial respiratory chain provides energy to cells via oxidative phosphorylation and consists of four membrane-bound electron-transporting protein complexes (I-IV) and an ATP synthase (complex V). This gene encodes a 51 kDa subunit of the NADH:ubiquinone oxidoreductase complex I; a large complex with at least 45 nuclear and mitochondrial encoded subunits that liberates electrons from NADH and channels them to ubiquinone. This subunit carries the NADH-binding site as well as flavin mononucleotide (FMN)- and Fe-S-biding sites. Defects in complex I are a common cause of mitochondrial dysfunction; a syndrome that occurs in approximately 1 in ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000322776
  • ENSP00000322450
  • ENSG00000167792
  • ENST00000529927
  • ENSP00000436766
  • ENST00000647561
  • ENSP00000497587

Symbol
  • UQOR1
  • UQOR1
  • CI-51K
  • CI51KD
  • MC1DN4
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
co-expressed gene
0.99
histone modification site profile
0.91
molecular function
0.88
transcription factor binding site profile
0.87


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.6   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 235   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 48.6   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 235   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
metformin
chemical structure image
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase core subunit V1
VGNC:6493
747209
Macaque
NADH:ubiquinone oxidoreductase core subunit V1
711412
Mouse
MGI:107851
17995
Rat
RGD:1359247
293655
Dog
NADH:ubiquinone oxidoreductase core subunit V1
VGNC:43711
476004
Species
Name
OMA
EggNOG
Inparanoid
Chimp
NADH:ubiquinone oxidoreductase core subunit V1
Macaque
NADH:ubiquinone oxidoreductase core subunit V1
Mouse
Rat
Dog
NADH:ubiquinone oxidoreductase core subunit V1
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P49821-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Complex I biogenesis (R-HSA-6799198)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complex I biogenesis
Reactome
Metabolism
Reactome
Respiratory electron transport
Reactome
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
Reactome
The citric acid (TCA) cycle and respiratory electron transport
Name
Explore in Pharos
Explore in Source
Complex I biogenesis
Metabolism
Respiratory electron transport
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.
The citric acid (TCA) cycle and respiratory electron transport
Gene Ontology Terms (12)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (209)
1 – 10 of 209
NDUFV3
Tclin
Family: Enzyme
Novelty: 0.15352039
p_int: 0.999989947
p_ni: 0.000010053
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB11
Tclin
Family: Enzyme
Novelty: 0.0401232
p_int: 0.999258466
p_ni: 0.000741534
Score: 0.996
Data Source: BioPlex,STRINGDB
NDUFS6
Tclin
Family: Enzyme
Novelty: 0.07910252
p_int: 0.998407096
p_ni: 0.001592904
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS3
Tclin
Family: Enzyme
Novelty: 0.01968313
p_int: 0.996261238
p_ni: 0.003738762
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA7
Tclin
Family: Enzyme
Novelty: 0.16417588
p_int: 0.990300514
p_ni: 0.009699486
Score: 0.998
Data Source: BioPlex,STRINGDB
NDUFA8
Tclin
Family: Enzyme
Novelty: 0.05772867
p_int: 0.986829714
p_ni: 0.013170286
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFB3
Tclin
Family: Enzyme
Novelty: 0.13020753
p_int: 0.969956733
p_ni: 0.030043267
Score: 0.997
Data Source: BioPlex,STRINGDB
NDUFS7
Tclin
Family: Enzyme
Novelty: 0.01562198
p_int: 0.84557451
p_ni: 0.15442549
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFA9
Tclin
Family: Enzyme
Novelty: 0.00637307
p_int: 0.78230686
p_ni: 0.21769314
Score: 0.999
Data Source: BioPlex,STRINGDB
NDUFS2
Tclin
Family: Enzyme
Novelty: 0.02347576
Score: 0.999
Data Source: STRINGDB
Publication Statistics
PubMed Score  48.60

PubMed score by year
PubTator Score  30.6

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer